======= VGF =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VGF
  * **<color #00a2e8>Official Name</color>**: VGF nerve growth factor inducible
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7425|7425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15240|O15240]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VGF&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VGF|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602186|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. {ECO:0000250}. Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris. {ECO:0000269|PubMed:23250050}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to dietary excess|
|neuropeptide hormone activity|
|insulin secretion|
|response to cold|
|ovarian follicle development|
|peptide hormone secretion|
|hormone secretion|
|hormone transport|
|female gonad development|
|transport vesicle|
|development of primary female sexual characteristics|
|response to cAMP|
|female sex differentiation|
|response to organophosphorus|
|response to purine-containing compound|
|protein secretion|
|establishment of protein localization to extracellular region|
|growth factor activity|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|response to temperature stimulus|
|glucose homeostasis|
|carbohydrate homeostasis|
|gonad development|
|development of primary sexual characteristics|
|response to insulin|
|cytoplasmic vesicle|
|sex differentiation|
|endoplasmic reticulum lumen|
|defense response to bacterium|
|post-translational protein modification|
|response to peptide hormone|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of hormone levels|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|response to bacterium|
|molecular function|
|sexual reproduction|
|response to hormone|
|response to organic cyclic compound|
|defense response to other organism|
|Golgi apparatus|
|multi-organism reproductive process|
|response to organonitrogen compound|
|secretion by cell|
|export from cell|
|response to nitrogen compound|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|protein transport|
|peptide transport|
|response to oxygen-containing compound|
|amide transport|
|extracellular space|
|establishment of protein localization|
|homeostatic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-2.14|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.72|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10091
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VGF Expression in NALM6 Cells: 0.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>