======= VPS11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS11
  * **<color #00a2e8>Official Name</color>**: VPS11 core subunit of CORVET and HOPS complexes
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55823|55823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H270|Q9H270]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608549|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995). {ECO:0000269|PubMed:21148287, ECO:0000269|PubMed:23593995, ECO:0000269|PubMed:25783203, ECO:0000305|PubMed:11382755, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24554770, ECO:0000305|PubMed:25266290, ECO:0000305|PubMed:25783203}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of early endosome to late endosome transport|
|endosomal vesicle fusion|
|regulation of SNARE complex assembly|
|positive regulation of cytoplasmic transport|
|HOPS complex|
|regulation of early endosome to late endosome transport|
|regulation of cytoplasmic transport|
|regulation of vesicle fusion|
|positive regulation of protein targeting to mitochondrion|
|vesicle docking involved in exocytosis|
|regulation of protein targeting to mitochondrion|
|endosome to lysosome transport|
|syntaxin binding|
|clathrin-coated vesicle|
|positive regulation of establishment of protein localization to mitochondrion|
|endocytic vesicle|
|nucleotide binding|
|vesicle docking|
|exocytic process|
|autophagosome|
|vesicle fusion|
|regulation of establishment of protein localization to mitochondrion|
|endosome organization|
|organelle membrane fusion|
|protein binding, bridging|
|regulation of protein targeting|
|organelle fusion|
|lysosomal transport|
|positive regulation of mitochondrion organization|
|late endosome membrane|
|late endosome|
|vacuole organization|
|membrane fusion|
|positive regulation of cellular protein catabolic process|
|vacuolar transport|
|positive regulation of intracellular protein transport|
|organelle localization by membrane tethering|
|membrane docking|
|regulation of mitochondrion organization|
|positive regulation of intracellular transport|
|positive regulation of protein catabolic process|
|regulation of organelle assembly|
|regulation of intracellular protein transport|
|protein domain specific binding|
|regulation of cellular protein catabolic process|
|lysosome|
|early endosome|
|process utilizing autophagic mechanism|
|autophagy|
|endosome|
|regulation of protein stability|
|vesicle organization|
|lysosomal membrane|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|organelle localization|
|positive regulation of organelle organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|exocytosis|
|regulation of cellular catabolic process|
|membrane organization|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|intracellular protein transport|
|regulation of catabolic process|
|secretion by cell|
|regulation of protein localization|
|export from cell|
|secretion|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.84|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.432|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.421|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1873
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS11 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>