======= VPS35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS35
  * **<color #00a2e8>Official Name</color>**: VPS35 retromer complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55737|55737]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QK1|Q96QK1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601501|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps35|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of locomotion involved in locomotory behavior|
|regulation of terminal button organization|
|positive regulation of dopamine biosynthetic process|
|regulation of dopamine biosynthetic process|
|negative regulation of vacuolar transport|
|negative regulation of late endosome to lysosome transport|
|positive regulation of Wnt protein secretion|
|mitochondrion to lysosome transport|
|mitochondrion-derived vesicle|
|mitochondrion-derived vesicle mediated transport|
|negative regulation of protein catabolic process in the vacuole|
|negative regulation of lysosomal protein catabolic process|
|regulation of Wnt protein secretion|
|regulation of late endosome to lysosome transport|
|retromer, cargo-selective complex|
|tubular endosome|
|regulation of vacuolar transport|
|positive regulation of dopamine receptor signaling pathway|
|regulation of locomotion involved in locomotory behavior|
|positive regulation of dopamine metabolic process|
|positive regulation of catecholamine metabolic process|
|voluntary musculoskeletal movement|
|regulation of lysosomal protein catabolic process|
|positive regulation of cellular amine metabolic process|
|D1 dopamine receptor binding|
|regulation of protein catabolic process in the vacuole|
|mitochondrial fragmentation involved in apoptotic process|
|negative regulation of protein homooligomerization|
|neurotransmitter receptor transport, endosome to plasma membrane|
|neurotransmitter receptor transport, endosome to postsynaptic membrane|
|regulation of dopamine receptor signaling pathway|
|endosome to plasma membrane protein transport|
|positive regulation of cellular response to drug|
|regulation of dendritic spine maintenance|
|protein localization to endosome|
|positive regulation of mitochondrial fission|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|negative regulation of protein oligomerization|
|transcytosis|
|establishment of protein localization to postsynaptic membrane|
|regulation of protein homooligomerization|
|retromer complex|
|regulation of catecholamine metabolic process|
|regulation of dopamine metabolic process|
|regulation of mitochondrial fission|
|retrograde transport, endosome to plasma membrane|
|positive regulation of behavior|
|regulation of presynapse assembly|
|regulation of presynapse organization|
|positive regulation of response to drug|
|protein localization to postsynaptic membrane|
|neurotransmitter receptor transport|
|regulation of cellular response to drug|
|receptor localization to synapse|
|regulation of protein oligomerization|
|musculoskeletal movement|
|multicellular organismal movement|
|protein destabilization|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment of protein localization to plasma membrane|
|lysosome organization|
|lytic vacuole organization|
|apoptotic mitochondrial changes|
|protein localization to synapse|
|regulation of behavior|
|regulation of cellular amine metabolic process|
|negative regulation of cellular protein catabolic process|
|vesicle-mediated transport to the plasma membrane|
|retrograde transport, endosome to Golgi|
|synapse assembly|
|presynapse|
|regulation of postsynapse organization|
|regulation of response to drug|
|regulation of synapse assembly|
|lysosomal transport|
|negative regulation of cellular protein localization|
|positive regulation of mitochondrion organization|
|late endosome|
|vacuole organization|
|vesicle-mediated transport in synapse|
|negative regulation of protein complex assembly|
|negative regulation of protein catabolic process|
|negative regulation of inflammatory response|
|positive regulation of cellular protein catabolic process|
|vacuolar transport|
|positive regulation of canonical Wnt signaling pathway|
|cytosolic transport|
|regulation of macroautophagy|
|positive regulation of Wnt signaling pathway|
|regulation of mitochondrion organization|
|protein localization to plasma membrane|
|negative regulation of neuron death|
|negative regulation of defense response|
|endosome membrane|
|mitochondrial transport|
|positive regulation of protein catabolic process|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|endosomal transport|
|protein localization to cell periphery|
|regulation of cellular protein catabolic process|
|lysosome|
|postsynaptic density|
|negative regulation of cellular catabolic process|
|early endosome|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|synapse organization|
|positive regulation of protein secretion|
|endosome|
|regulation of canonical Wnt signaling pathway|
|regulation of protein stability|
|positive regulation of peptide secretion|
|lysosomal membrane|
|negative regulation of catabolic process|
|regulation of neuron death|
|neuron projection|
|regulation of autophagy|
|regulation of inflammatory response|
|glutamatergic synapse|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|negative regulation of response to external stimulus|
|neuronal cell body|
|regulation of protein catabolic process|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|positive regulation of secretion|
|mitochondrion organization|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|protein localization to membrane|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of cellular protein localization|
|positive regulation of locomotion|
|positive regulation of organelle organization|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|viral process|
|negative regulation of cellular component organization|
|regulation of protein transport|
|regulation of cell projection organization|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|regulation of cellular localization|
|apoptotic process|
|regulation of nervous system development|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|intracellular protein transport|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of organelle organization|
|positive regulation of developmental process|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.1|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.06|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-1.97|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.96|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|-1.95|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.93|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.91|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.84|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.81|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.79|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-1.76|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.87|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.09|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:v:vps29|VPS29]]|0.595|
|[[:human genes:v:vps26a|VPS26A]]|0.566|
|[[:human genes:c:ccdc22|CCDC22]]|0.474|
|[[:human genes:c:commd3|COMMD3]]|0.455|
|[[:human genes:a:arpc2|ARPC2]]|0.428|
|[[:human genes:c:commd5|COMMD5]]|0.424|
|[[:human genes:m:mapkapk5|MAPKAPK5]]|0.419|
|[[:human genes:c:ccdc47|CCDC47]]|0.415|
|[[:human genes:o:odc1|ODC1]]|0.412|
|[[:human genes:v:vps41|VPS41]]|0.411|
|[[:human genes:a:ahcyl1|AHCYL1]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 43/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|4/28|
|bone|1/26|
|breast|2/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2543
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS35 Expression in NALM6 Cells: 7.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>