======= VPS4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VPS4B
  * **<color #00a2e8>Official Name</color>**: vacuolar protein sorting 4 homolog B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9525|9525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75351|O75351]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VPS4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VPS4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609983|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). {ECO:0000269|PubMed:11563910, ECO:0000269|PubMed:14505570, ECO:0000269|PubMed:18687924, ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps4 C|
|AAA|
|MIT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|late endosomal microautophagy|
|negative regulation of exosomal secretion|
|positive regulation of centriole elongation|
|regulation of centriole elongation|
|ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway|
|exit from host|
|viral release from host cell|
|positive regulation of centriole replication|
|movement in host environment|
|movement in environment of other organism involved in symbiotic interaction|
|exit from host cell|
|endosome to lysosome transport via multivesicular body sorting pathway|
|positive regulation of centrosome duplication|
|ESCRT III complex disassembly|
|ESCRT complex disassembly|
|positive regulation of centrosome cycle|
|positive regulation of viral release from host cell|
|positive regulation of exosomal secretion|
|midbody abscission|
|regulation of exosomal secretion|
|ATPase activity, coupled|
|viral budding via host ESCRT complex|
|mitotic cytokinetic process|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|regulation of mitotic spindle assembly|
|regulation of centriole replication|
|viral budding|
|endosome transport via multivesicular body sorting pathway|
|positive regulation of G2/M transition of mitotic cell cycle|
|Flemming body|
|regulation of spindle assembly|
|positive regulation of cell cycle G2/M phase transition|
|multivesicular body assembly|
|regulation of viral release from host cell|
|multivesicular body organization|
|negative regulation of exocytosis|
|multivesicular body sorting pathway|
|cytokinetic process|
|protein depolymerization|
|virion assembly|
|regulation of mitotic spindle organization|
|regulation of centrosome duplication|
|regulation of spindle organization|
|mitotic metaphase plate congression|
|endosome to lysosome transport|
|cholesterol transport|
|metaphase plate congression|
|regulation of centrosome cycle|
|positive regulation of viral life cycle|
|sterol transport|
|mitotic cytokinesis|
|establishment of chromosome localization|
|positive regulation of organelle assembly|
|chromosome localization|
|endosome organization|
|positive regulation of mitotic cell cycle phase transition|
|positive regulation of exocytosis|
|positive regulation of cell cycle phase transition|
|cytoskeleton-dependent cytokinesis|
|cytokinesis|
|lysosomal transport|
|positive regulation of viral process|
|mitotic sister chromatid segregation|
|late endosome membrane|
|spindle pole|
|vacuole organization|
|nucleus organization|
|organic hydroxy compound transport|
|cellular protein complex disassembly|
|vacuolar transport|
|sister chromatid segregation|
|regulation of viral life cycle|
|mitotic nuclear division|
|positive regulation of mitotic cell cycle|
|interaction with host|
|macroautophagy|
|regulation of mitotic nuclear division|
|potassium ion transport|
|protein C-terminus binding|
|regulation of microtubule cytoskeleton organization|
|regulation of nuclear division|
|regulation of G2/M transition of mitotic cell cycle|
|viral life cycle|
|negative regulation of secretion by cell|
|regulation of viral process|
|regulation of cell cycle G2/M phase transition|
|endosome membrane|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|regulation of exocytosis|
|endosomal transport|
|negative regulation of secretion|
|ATPase activity|
|protein-containing complex disassembly|
|autophagy|
|process utilizing autophagic mechanism|
|endosome|
|chromosome segregation|
|nuclear division|
|positive regulation of cell cycle process|
|lipid transport|
|vesicle organization|
|organelle fission|
|lipid localization|
|establishment of organelle localization|
|positive regulation of cell cycle|
|monovalent inorganic cation transport|
|cellular component disassembly|
|positive regulation of secretion by cell|
|regulation of mitotic cell cycle phase transition|
|endomembrane system organization|
|positive regulation of secretion|
|regulation of cell cycle phase transition|
|negative regulation of transport|
|centrosome|
|cell division|
|positive regulation of multi-organism process|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cytoskeleton organization|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|organelle localization|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|metal ion transport|
|mitotic cell cycle|
|protein catabolic process|
|viral process|
|regulation of secretion by cell|
|regulation of cell cycle process|
|organelle assembly|
|regulation of multi-organism process|
|symbiotic process|
|regulation of secretion|
|interspecies interaction between organisms|
|cation transport|
|membrane organization|
|response to lipid|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|identical protein binding|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|locomotion|
|cell cycle|
|ion transport|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.94|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.77|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 32/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VPS4B Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>