======= WARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WARS2
  * **<color #00a2e8>Official Name</color>**: tryptophanyl tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10352|10352]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UGM6|Q9UGM6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. {ECO:0000305|PubMed:28650581}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1b|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial tryptophanyl-tRNA aminoacylation|
|tryptophanyl-tRNA aminoacylation|
|tryptophan-tRNA ligase activity|
|tRNA aminoacylation for mitochondrial protein translation|
|mitochondrial RNA metabolic process|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|vasculogenesis|
|mitochondrial translation|
|mitochondrial gene expression|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|mitochondrial matrix|
|translation|
|peptide biosynthetic process|
|blood vessel morphogenesis|
|ncRNA metabolic process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|amide biosynthetic process|
|peptide metabolic process|
|tube morphogenesis|
|cellular amide metabolic process|
|tube development|
|circulatory system development|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.77|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.74|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.74|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.76|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.77|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.78|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.79|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.79|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.8|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.97|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.99|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.02|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.09|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.1|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.15|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.21|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|2.29|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.31|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:q:qrsl1|QRSL1]]|0.629|
|[[:human genes:n:nars2|NARS2]]|0.616|
|[[:human genes:p:pet112|PET112]]|0.6|
|[[:human genes:s:selrc1|SELRC1]]|0.595|
|[[:human genes:s:sco2|SCO2]]|0.592|
|[[:human genes:p:pet117|PET117]]|0.585|
|[[:human genes:l:lars2|LARS2]]|0.58|
|[[:human genes:p:polg2|POLG2]]|0.579|
|[[:human genes:a:aars2|AARS2]]|0.577|
|[[:human genes:e:ears2|EARS2]]|0.572|
|[[:human genes:t:tars2|TARS2]]|0.551|
|[[:human genes:y:yars2|YARS2]]|0.55|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.548|
|[[:human genes:p:pars2|PARS2]]|0.548|
|[[:human genes:p:polg|POLG]]|0.538|
|[[:human genes:c:coa3|COA3]]|0.537|
|[[:human genes:g:gfm2|GFM2]]|0.53|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.529|
|[[:human genes:m:mrps6|MRPS6]]|0.526|
|[[:human genes:m:mtg1|MTG1]]|0.525|
|[[:human genes:g:gfm1|GFM1]]|0.522|
|[[:human genes:f:ftsj2|FTSJ2]]|0.522|
|[[:human genes:a:acad9|ACAD9]]|0.521|
|[[:human genes:t:tfb1m|TFB1M]]|0.519|
|[[:human genes:r:rars2|RARS2]]|0.517|
|[[:human genes:m:mrpl45|MRPL45]]|0.515|
|[[:human genes:n:ndufb11|NDUFB11]]|0.514|
|[[:human genes:c:cox11|COX11]]|0.514|
|[[:human genes:m:mettl17|METTL17]]|0.513|
|[[:human genes:m:mrps34|MRPS34]]|0.512|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.511|
|[[:human genes:g:gatc|GATC]]|0.509|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.508|
|[[:human genes:m:mrps16|MRPS16]]|0.506|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.502|
|[[:human genes:d:dap3|DAP3]]|0.498|
|[[:human genes:g:grsf1|GRSF1]]|0.495|
|[[:human genes:m:mtif2|MTIF2]]|0.491|
|[[:human genes:m:mrps25|MRPS25]]|0.491|
|[[:human genes:m:mrps23|MRPS23]]|0.49|
|[[:human genes:v:vars2|VARS2]]|0.487|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.486|
|[[:human genes:r:rpusd4|RPUSD4]]|0.483|
|[[:human genes:m:mrps21|MRPS21]]|0.483|
|[[:human genes:m:mrpl21|MRPL21]]|0.481|
|[[:human genes:m:mars2|MARS2]]|0.479|
|[[:human genes:c:cars2|CARS2]]|0.478|
|[[:human genes:c:coa6|COA6]]|0.478|
|[[:human genes:m:mipep|MIPEP]]|0.477|
|[[:human genes:d:dars2|DARS2]]|0.475|
|[[:human genes:w:wbscr16|WBSCR16]]|0.475|
|[[:human genes:m:mrp63|MRP63]]|0.475|
|[[:human genes:b:bcs1l|BCS1L]]|0.474|
|[[:human genes:m:mtg2|MTG2]]|0.468|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.467|
|[[:human genes:n:nsun4|NSUN4]]|0.466|
|[[:human genes:p:pitrm1|PITRM1]]|0.465|
|[[:human genes:f:fastkd5|FASTKD5]]|0.464|
|[[:human genes:c:c10orf2|C10orf2]]|0.464|
|[[:human genes:n:ndufa1|NDUFA1]]|0.464|
|[[:human genes:r:rbfa|RBFA]]|0.462|
|[[:human genes:m:mrps18a|MRPS18A]]|0.461|
|[[:human genes:n:ndufs2|NDUFS2]]|0.46|
|[[:human genes:t:tefm|TEFM]]|0.46|
|[[:human genes:m:mrpl23|MRPL23]]|0.459|
|[[:human genes:m:mrps27|MRPS27]]|0.458|
|[[:human genes:m:mrps26|MRPS26]]|0.458|
|[[:human genes:f:fastkd2|FASTKD2]]|0.451|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.451|
|[[:human genes:m:mterfd2|MTERFD2]]|0.45|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.45|
|[[:human genes:c:cox20|COX20]]|0.45|
|[[:human genes:c:coq2|COQ2]]|0.446|
|[[:human genes:m:mrps18b|MRPS18B]]|0.446|
|[[:human genes:m:mrps10|MRPS10]]|0.446|
|[[:human genes:m:mrpl22|MRPL22]]|0.446|
|[[:human genes:c:cox15|COX15]]|0.445|
|[[:human genes:n:ndufc2|NDUFC2]]|0.445|
|[[:human genes:n:ndufs5|NDUFS5]]|0.445|
|[[:human genes:n:ndufa2|NDUFA2]]|0.445|
|[[:human genes:n:ndufa3|NDUFA3]]|0.443|
|[[:human genes:t:trub2|TRUB2]]|0.442|
|[[:human genes:c:c12orf65|C12orf65]]|0.441|
|[[:human genes:p:polrmt|POLRMT]]|0.441|
|[[:human genes:s:slc25a51|SLC25A51]]|0.44|
|[[:human genes:m:mrpl47|MRPL47]]|0.44|
|[[:human genes:d:ddx28|DDX28]]|0.44|
|[[:human genes:m:mrpl3|MRPL3]]|0.439|
|[[:human genes:m:mrps14|MRPS14]]|0.439|
|[[:human genes:x:xpnpep3|XPNPEP3]]|0.439|
|[[:human genes:h:hars2|HARS2]]|0.436|
|[[:human genes:m:malsu1|MALSU1]]|0.434|
|[[:human genes:t:tmem242|TMEM242]]|0.434|
|[[:human genes:t:tomm20|TOMM20]]|0.434|
|[[:human genes:i:iba57|IBA57]]|0.433|
|[[:human genes:e:eral1|ERAL1]]|0.432|
|[[:human genes:n:nubpl|NUBPL]]|0.425|
|[[:human genes:f:fars2|FARS2]]|0.424|
|[[:human genes:t:trit1|TRIT1]]|0.424|
|[[:human genes:m:mrps5|MRPS5]]|0.423|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.422|
|[[:human genes:t:trmt61a|TRMT61A]]|0.421|
|[[:human genes:p:ptcd3|PTCD3]]|0.42|
|[[:human genes:m:mrps22|MRPS22]]|0.42|
|[[:human genes:a:atp5sl|ATP5SL]]|0.419|
|[[:human genes:n:ndufb5|NDUFB5]]|0.419|
|[[:human genes:m:mrpl53|MRPL53]]|0.418|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.418|
|[[:human genes:m:mrpl28|MRPL28]]|0.418|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.418|
|[[:human genes:c:coq7|COQ7]]|0.417|
|[[:human genes:e:ecsit|ECSIT]]|0.417|
|[[:human genes:m:mrpl48|MRPL48]]|0.417|
|[[:human genes:m:mrpl11|MRPL11]]|0.416|
|[[:human genes:p:prim1|PRIM1]]|0.415|
|[[:human genes:n:ndufb9|NDUFB9]]|0.415|
|[[:human genes:n:ndufv1|NDUFV1]]|0.415|
|[[:human genes:m:mrpl17|MRPL17]]|0.415|
|[[:human genes:m:mrps2|MRPS2]]|0.414|
|[[:human genes:a:aifm1|AIFM1]]|0.413|
|[[:human genes:c:coq3|COQ3]]|0.413|
|[[:human genes:c:clpp|CLPP]]|0.412|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.411|
|[[:human genes:m:mrpl20|MRPL20]]|0.41|
|[[:human genes:f:foxred1|FOXRED1]]|0.41|
|[[:human genes:t:tsfm|TSFM]]|0.41|
|[[:human genes:m:mcat|MCAT]]|0.41|
|[[:human genes:m:mrpl12|MRPL12]]|0.409|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.409|
|[[:human genes:c:cox7b|COX7B]]|0.408|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.408|
|[[:human genes:r:rpusd3|RPUSD3]]|0.408|
|[[:human genes:f:fastkd1|FASTKD1]]|0.407|
|[[:human genes:n:ndufa8|NDUFA8]]|0.407|
|[[:human genes:t:tomm6|TOMM6]]|0.404|
|[[:human genes:m:mrps12|MRPS12]]|0.404|
|[[:human genes:m:mterfd1|MTERFD1]]|0.404|
|[[:human genes:m:mrpl44|MRPL44]]|0.403|
|[[:human genes:p:pgm3|PGM3]]|0.402|
|[[:human genes:m:mtpap|MTPAP]]|0.401|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.401|
|[[:human genes:m:mrpl42|MRPL42]]|0.4|
|[[:human genes:l:lrpprc|LRPPRC]]|0.4|
|[[:human genes:d:dhrsx|DHRSX]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1467
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WARS2 Expression in NALM6 Cells: 3.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>