======= WASF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WASF1
  * **<color #00a2e8>Official Name</color>**: WASP family member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8936|8936]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92558|Q92558]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WASF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WASF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605035|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). {ECO:0000250|UniProtKB:Q8R5H6, ECO:0000269|PubMed:9889097}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dendritic transport of mitochondrion|
|modification of postsynaptic actin cytoskeleton|
|lamellipodium morphogenesis|
|positive regulation of neurotrophin TRK receptor signaling pathway|
|positive regulation of Arp2/3 complex-mediated actin nucleation|
|SCAR complex|
|dendritic transport|
|modification of postsynaptic structure|
|cellular response to brain-derived neurotrophic factor stimulus|
|dendrite extension|
|regulation of neurotrophin TRK receptor signaling pathway|
|modification of synaptic structure|
|positive regulation of actin nucleation|
|regulation of Arp2/3 complex-mediated actin nucleation|
|mitochondrion transport along microtubule|
|establishment of mitochondrion localization, microtubule-mediated|
|Rac protein signal transduction|
|establishment of mitochondrion localization|
|protein kinase A binding|
|regulation of actin nucleation|
|dendrite cytoplasm|
|actin filament polymerization|
|lamellipodium organization|
|mitochondrion localization|
|cellular response to nerve growth factor stimulus|
|actin polymerization or depolymerization|
|response to nerve growth factor|
|Rac GTPase binding|
|neuron projection extension|
|axo-dendritic transport|
|organelle transport along microtubule|
|postsynapse|
|protein polymerization|
|developmental cell growth|
|cell growth|
|positive regulation of actin filament polymerization|
|developmental growth involved in morphogenesis|
|positive regulation of protein polymerization|
|transport along microtubule|
|mitochondrial outer membrane|
|regulation of actin filament polymerization|
|cytoskeleton-dependent intracellular transport|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|microtubule-based transport|
|regulation of actin filament length|
|positive regulation of supramolecular fiber organization|
|actin cytoskeleton|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|receptor-mediated endocytosis|
|actin filament organization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|actin binding|
|synapse organization|
|microtubule-based movement|
|regulation of cellular response to growth factor stimulus|
|small GTPase mediated signal transduction|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|establishment of organelle localization|
|cytoskeleton|
|regulation of cellular component size|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|focal adhesion|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|regulation of cytoskeleton organization|
|endocytosis|
|actin filament-based process|
|organelle localization|
|protein-containing complex|
|positive regulation of organelle organization|
|neuron projection development|
|microtubule-based process|
|import into cell|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|regulation of cellular component biogenesis|
|neuron differentiation|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|response to endogenous stimulus|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-2|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.86|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.77|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|1.72|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.87|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.95|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.14|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.16|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11138
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WASF1 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>