======= WDR24 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR24
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 24
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84219|84219]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96S15|Q96S15]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR24&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR24|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620307|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:26449471, ECO:0000269|PubMed:26586190, ECO:0000269|PubMed:27166823, ECO:0000269|PubMed:27487210}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GATOR2 complex|
|positive regulation of TOR signaling|
|cellular response to amino acid starvation|
|response to amino acid starvation|
|regulation of TOR signaling|
|cellular response to starvation|
|response to starvation|
|cellular response to nutrient levels|
|autophagy|
|process utilizing autophagic mechanism|
|cellular response to extracellular stimulus|
|lysosomal membrane|
|regulation of autophagy|
|cellular response to external stimulus|
|response to nutrient levels|
|response to extracellular stimulus|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|positive regulation of intracellular signal transduction|
|positive regulation of signal transduction|
|cellular response to stress|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.78|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.7|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.72|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.75|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.76|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.81|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.85|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.88|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.9|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.93|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.93|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.97|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.01|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.02|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.02|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.06|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.11|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.12|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.19|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.21|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.22|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.3|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.31|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.34|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.43|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.48|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.66|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.74|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.78|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.89|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.91|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.93|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|3.26|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|3.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rptor|RPTOR]]|0.787|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.724|
|[[:human genes:w:wdr59|WDR59]]|0.698|
|[[:human genes:m:mios|MIOS]]|0.693|
|[[:human genes:m:mtor|MTOR]]|0.665|
|[[:human genes:l:lamtor2|LAMTOR2]]|0.652|
|[[:human genes:d:dohh|DOHH]]|0.646|
|[[:human genes:f:flcn|FLCN]]|0.605|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.597|
|[[:human genes:f:fnip1|FNIP1]]|0.591|
|[[:human genes:m:mllt1|MLLT1]]|0.589|
|[[:human genes:z:znf592|ZNF592]]|0.582|
|[[:human genes:c:ccdc101|CCDC101]]|0.577|
|[[:human genes:t:thg1l|THG1L]]|0.577|
|[[:human genes:r:rnmt|RNMT]]|0.574|
|[[:human genes:m:med16|MED16]]|0.571|
|[[:human genes:v:vhl|VHL]]|0.569|
|[[:human genes:m:mlst8|MLST8]]|0.564|
|[[:human genes:m:meaf6|MEAF6]]|0.556|
|[[:human genes:m:med23|MED23]]|0.556|
|[[:human genes:f:fbxo11|FBXO11]]|0.556|
|[[:human genes:i:id3|ID3]]|0.555|
|[[:human genes:c:cbfb|CBFB]]|0.552|
|[[:human genes:p:pmm2|PMM2]]|0.543|
|[[:human genes:l:lamtor3|LAMTOR3]]|0.542|
|[[:human genes:g:gnb1l|GNB1L]]|0.538|
|[[:human genes:e:eif4e|EIF4E]]|0.536|
|[[:human genes:t:triap1|TRIAP1]]|0.535|
|[[:human genes:t:tle4|TLE4]]|0.534|
|[[:human genes:t:tti2|TTI2]]|0.534|
|[[:human genes:a:alg1|ALG1]]|0.531|
|[[:human genes:v:vps41|VPS41]]|0.527|
|[[:human genes:g:gmppb|GMPPB]]|0.525|
|[[:human genes:d:dpagt1|DPAGT1]]|0.523|
|[[:human genes:u:ube2g2|UBE2G2]]|0.522|
|[[:human genes:e:eny2|ENY2]]|0.52|
|[[:human genes:u:uhrf1|UHRF1]]|0.519|
|[[:human genes:p:pelo|PELO]]|0.517|
|[[:human genes:r:rraga|RRAGA]]|0.516|
|[[:human genes:t:trnt1|TRNT1]]|0.512|
|[[:human genes:t:trim28|TRIM28]]|0.508|
|[[:human genes:n:nsd1|NSD1]]|0.506|
|[[:human genes:t:thoc6|THOC6]]|0.505|
|[[:human genes:m:mapk14|MAPK14]]|0.503|
|[[:human genes:s:serf2|SERF2]]|0.503|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.5|
|[[:human genes:g:gfpt1|GFPT1]]|0.5|
|[[:human genes:h:hars|HARS]]|0.499|
|[[:human genes:f:faf2|FAF2]]|0.498|
|[[:human genes:d:dr1|DR1]]|0.497|
|[[:human genes:a:aars|AARS]]|0.496|
|[[:human genes:t:tbc1d5|TBC1D5]]|0.493|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.492|
|[[:human genes:t:tbp|TBP]]|0.492|
|[[:human genes:t:tmem41b|TMEM41B]]|0.491|
|[[:human genes:b:brpf1|BRPF1]]|0.491|
|[[:human genes:t:tti1|TTI1]]|0.49|
|[[:human genes:b:btaf1|BTAF1]]|0.488|
|[[:human genes:b:bak1|BAK1]]|0.488|
|[[:human genes:d:dhps|DHPS]]|0.487|
|[[:human genes:c:csnk2b|CSNK2B]]|0.487|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.485|
|[[:human genes:p:plaa|PLAA]]|0.482|
|[[:human genes:s:seh1l|SEH1L]]|0.481|
|[[:human genes:h:hspd1|HSPD1]]|0.479|
|[[:human genes:b:bap1|BAP1]]|0.478|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.478|
|[[:human genes:e:eif4g1|EIF4G1]]|0.477|
|[[:human genes:l:lsmd1|LSMD1]]|0.477|
|[[:human genes:c:casp9|CASP9]]|0.476|
|[[:human genes:o:otud5|OTUD5]]|0.475|
|[[:human genes:r:rtcb|RTCB]]|0.473|
|[[:human genes:r:romo1|ROMO1]]|0.468|
|[[:human genes:s:ssbp2|SSBP2]]|0.467|
|[[:human genes:a:alg2|ALG2]]|0.466|
|[[:human genes:s:srp14|SRP14]]|0.465|
|[[:human genes:a:alg13|ALG13]]|0.461|
|[[:human genes:l:lamtor1|LAMTOR1]]|0.46|
|[[:human genes:v:vdac2|VDAC2]]|0.46|
|[[:human genes:t:telo2|TELO2]]|0.457|
|[[:human genes:t:trmt5|TRMT5]]|0.457|
|[[:human genes:a:alg5|ALG5]]|0.455|
|[[:human genes:v:vmp1|VMP1]]|0.455|
|[[:human genes:c:cct7|CCT7]]|0.454|
|[[:human genes:e:exoc4|EXOC4]]|0.454|
|[[:human genes:n:nae1|NAE1]]|0.454|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.452|
|[[:human genes:r:runx1|RUNX1]]|0.451|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.451|
|[[:human genes:d:dad1|DAD1]]|0.45|
|[[:human genes:m:max|MAX]]|0.449|
|[[:human genes:z:zzz3|ZZZ3]]|0.449|
|[[:human genes:d:dpf2|DPF2]]|0.447|
|[[:human genes:e:eed|EED]]|0.444|
|[[:human genes:p:pax5|PAX5]]|0.441|
|[[:human genes:u:uap1|UAP1]]|0.441|
|[[:human genes:s:ssb|SSB]]|0.439|
|[[:human genes:a:apaf1|APAF1]]|0.438|
|[[:human genes:p:pam16|PAM16]]|0.438|
|[[:human genes:l:lsm10|LSM10]]|0.438|
|[[:human genes:a:atxn10|ATXN10]]|0.436|
|[[:human genes:e:ezh2|EZH2]]|0.436|
|[[:human genes:c:cbx3|CBX3]]|0.435|
|[[:human genes:v:vps26a|VPS26A]]|0.435|
|[[:human genes:t:trmt10a|TRMT10A]]|0.434|
|[[:human genes:b:bptf|BPTF]]|0.432|
|[[:human genes:u:uba3|UBA3]]|0.432|
|[[:human genes:o:oraov1|ORAOV1]]|0.431|
|[[:human genes:e:eprs|EPRS]]|0.431|
|[[:human genes:u:ube2m|UBE2M]]|0.429|
|[[:human genes:e:elf2|ELF2]]|0.428|
|[[:human genes:m:march5|MARCH5]]|0.428|
|[[:human genes:c:crls1|CRLS1]]|0.428|
|[[:human genes:d:ddost|DDOST]]|0.427|
|[[:human genes:a:atp5j|ATP5J]]|0.424|
|[[:human genes:r:rpe|RPE]]|0.424|
|[[:human genes:d:diablo|DIABLO]]|0.424|
|[[:human genes:i:irf2|IRF2]]|0.423|
|[[:human genes:l:lsm11|LSM11]]|0.423|
|[[:human genes:v:vezt|VEZT]]|0.42|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.419|
|[[:human genes:z:znf608|ZNF608]]|0.418|
|[[:human genes:s:slc25a26|SLC25A26]]|0.418|
|[[:human genes:u:ube3a|UBE3A]]|0.418|
|[[:human genes:h:haus8|HAUS8]]|0.417|
|[[:human genes:t:taz|TAZ]]|0.416|
|[[:human genes:r:rpn1|RPN1]]|0.415|
|[[:human genes:m:mars|MARS]]|0.414|
|[[:human genes:m:med13l|MED13L]]|0.414|
|[[:human genes:t:taf5l|TAF5L]]|0.413|
|[[:human genes:c:cycs|CYCS]]|0.413|
|[[:human genes:u:usp22|USP22]]|0.412|
|[[:human genes:t:tmed10|TMED10]]|0.412|
|[[:human genes:e:eif3f|EIF3F]]|0.411|
|[[:human genes:t:ten1|TEN1]]|0.41|
|[[:human genes:o:osgep|OSGEP]]|0.409|
|[[:human genes:t:txnrd1|TXNRD1]]|0.407|
|[[:human genes:t:trip12|TRIP12]]|0.407|
|[[:human genes:p:ppp4c|PPP4C]]|0.406|
|[[:human genes:p:ppa2|PPA2]]|0.406|
|[[:human genes:t:txndc17|TXNDC17]]|0.405|
|[[:human genes:t:taf6l|TAF6L]]|0.404|
|[[:human genes:s:smarcd1|SMARCD1]]|0.404|
|[[:human genes:p:polr3h|POLR3H]]|0.404|
|[[:human genes:a:adsl|ADSL]]|0.403|
|[[:human genes:t:tada1|TADA1]]|0.403|
|[[:human genes:c:casp3|CASP3]]|0.402|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.402|
|[[:human genes:d:dnajc3|DNAJC3]]|0.401|
|[[:human genes:k:kdsr|KDSR]]|0.401|
|[[:human genes:s:srprb|SRPRB]]|0.401|
|[[:human genes:t:timm13|TIMM13]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 171/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|11/28|
|bone|8/26|
|breast|9/33|
|central nervous system|12/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|3/20|
|lung|21/75|
|lymphocyte|7/16|
|ovary|7/26|
|pancreas|7/24|
|peripheral nervous system|1/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|11/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 645
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR24 Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>