======= WDR26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR26
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80232|80232]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H7D7|Q9H7D7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617424|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  G-beta-like protein involved in cell signal transduction (PubMed:15378603, PubMed:19446606, PubMed:22065575, PubMed:23625927, PubMed:27098453, PubMed:26895380). Acts as a negative regulator in MAPK signaling pathway (PubMed:15378603). Functions as a scaffolding protein to promote G beta:gamma- mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes (PubMed:22065575, PubMed:23625927). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the beta-catenin destruction complex, thus negatively regulating CTNNB1 degradation (PubMed:27098453). Serves as a scaffold to coordinate PI3K/AKT pathway-driven cell growth and migration (PubMed:26895380). Protects cells from oxidative stress-induced apoptosis via the down-regulation of AP-1 transcriptional activity as well as by inhibiting cytochrome c release from mitochondria (PubMed:19446606). Protects also cells by promoting hypoxia- mediated autophagy and mitophagy (By similarity). {ECO:0000250|UniProtKB:F1LTR1, ECO:0000269|PubMed:15378603, ECO:0000269|PubMed:19446606, ECO:0000269|PubMed:23625927, ECO:0000269|PubMed:26895380, ECO:0000269|PubMed:27098453}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin ligase complex|
|mitochondrion|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-4.58|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.63|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-3.35|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.09|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-3.01|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.99|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.93|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.92|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-2.84|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.63|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.48|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.46|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.4|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.4|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.28|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.24|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.2|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-2.2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.14|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.06|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.96|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.95|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.89|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.88|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.87|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.85|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.85|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|-1.8|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.8|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.78|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.71|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.7|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.94|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.94|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.98|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.06|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.07|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|2.2|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.24|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.25|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.28|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.36|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.64|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.08|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.34|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|3.88|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|3.94|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|4.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:ypel5|YPEL5]]|0.822|
|[[:human genes:u:ube2h|UBE2H]]|0.765|
|[[:human genes:g:gid8|GID8]]|0.751|
|[[:human genes:m:maea|MAEA]]|0.697|
|[[:human genes:m:memo1|MEMO1]]|0.526|
|[[:human genes:r:rmnd5a|RMND5A]]|0.506|
|[[:human genes:c:cnot8|CNOT8]]|0.473|
|[[:human genes:o:otub1|OTUB1]]|0.466|
|[[:human genes:g:gskip|GSKIP]]|0.449|
|[[:human genes:a:anp32a|ANP32A]]|0.446|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.433|
|[[:human genes:f:fkbp1a|FKBP1A]]|0.422|
|[[:human genes:c:cnot2|CNOT2]]|0.416|
|[[:human genes:p:pcgf1|PCGF1]]|0.415|
|[[:human genes:k:kdm6a|KDM6A]]|0.413|
|[[:human genes:g:gsk3b|GSK3B]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|4/26|
|breast|3/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|5/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3796
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR26 Expression in NALM6 Cells: 6.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>