======= WDR35 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR35
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 35
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57539|57539]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2L0|Q9P2L0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR35&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR35|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613602|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Two patients with Sensenbrenner syndrome / cranioectodermal dysplasia (CED) were identified with mutations in this gene, consistent with a possible ciliary function.[provided by RefSeq, Sep 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis. {ECO:0000269|PubMed:20193664, ECO:0000269|PubMed:21473986}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to paclitaxel|
|cellular response to paclitaxel|
|intraciliary transport particle A|
|intraciliary retrograde transport|
|negative regulation of nitric oxide metabolic process|
|negative regulation of nitric oxide biosynthetic process|
|negative regulation of reactive oxygen species biosynthetic process|
|liver regeneration|
|positive regulation of release of cytochrome c from mitochondria|
|negative regulation of blood vessel diameter|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|protein localization to cilium|
|regulation of release of cytochrome c from mitochondria|
|intraciliary transport|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|microtubule-based protein transport|
|protein transport along microtubule|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|animal organ regeneration|
|cellular response to carbohydrate stimulus|
|regulation of reactive oxygen species biosynthetic process|
|cellular glucose homeostasis|
|response to antineoplastic agent|
|response to leukemia inhibitory factor|
|cellular response to leukemia inhibitory factor|
|axoneme|
|positive regulation of mitochondrion organization|
|liver development|
|hepaticobiliary system development|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|ciliary basal body|
|response to glucose|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|response to hexose|
|response to monosaccharide|
|positive regulation of cysteine-type endopeptidase activity|
|regeneration|
|transport along microtubule|
|vascular process in circulatory system|
|response to carbohydrate|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|cytoskeleton-dependent intracellular transport|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|microtubule-based transport|
|glucose homeostasis|
|carbohydrate homeostasis|
|positive regulation of peptidase activity|
|cilium|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|protein-containing complex localization|
|response to tumor necrosis factor|
|microtubule-based movement|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cilium assembly|
|regulation of neurotransmitter levels|
|positive regulation of proteolysis|
|cilium organization|
|blood circulation|
|circulatory system process|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|gland development|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|centrosome|
|response to toxic substance|
|regulation of anatomical structure size|
|cellular response to lipid|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|microtubule-based process|
|response to bacterium|
|positive regulation of cell death|
|regulation of proteolysis|
|protein localization to organelle|
|cellular chemical homeostasis|
|organelle assembly|
|positive regulation of hydrolase activity|
|response to lipid|
|cellular homeostasis|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|response to drug|
|cellular response to oxygen-containing compound|
|response to cytokine|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|positive regulation of catalytic activity|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.7|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|1.83|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.87|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15405
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR35 Expression in NALM6 Cells: -3.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>