======= WDR48 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR48
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 48
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57599|57599]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TAF3|Q8TAF3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR48&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR48|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612167|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene has been shown to interact with ubiquitin specific peptidase 1 (USP1), activating the deubiquitinating activity of USP1 and allowing it to remove the ubiquitin moiety from monoubiquitinated FANCD2. FANCD2 is ubiquitinated in response to DNA damage. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
|DUF3337|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of protein monoubiquitination|
|positive regulation of protein deubiquitination|
|regulation of protein deubiquitination|
|seminiferous tubule development|
|DNA damage response, detection of DNA damage|
|interstrand cross-link repair|
|ubiquitin binding|
|multicellular organism growth|
|double-strand break repair via homologous recombination|
|recombinational repair|
|late endosome|
|male gonad development|
|positive regulation of protein modification by small protein conjugation or removal|
|development of primary male sexual characteristics|
|single fertilization|
|male sex differentiation|
|fertilization|
|double-strand break repair|
|positive regulation of epithelial cell proliferation|
|regulation of protein ubiquitination|
|homeostasis of number of cells|
|gonad development|
|development of primary sexual characteristics|
|DNA recombination|
|regulation of protein modification by small protein conjugation or removal|
|skeletal system morphogenesis|
|lysosome|
|sex differentiation|
|protein deubiquitination|
|protein modification by small protein removal|
|regulation of epithelial cell proliferation|
|positive regulation of proteolysis|
|skin development|
|developmental growth|
|growth|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|skeletal system development|
|DNA repair|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|intracellular membrane-bounded organelle|
|detection of stimulus|
|gamete generation|
|viral process|
|regulation of proteolysis|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|positive regulation of cell population proliferation|
|animal organ morphogenesis|
|embryo development|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|positive regulation of protein modification process|
|proteolysis|
|reproductive process|
|reproduction|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-2.07|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-2.01|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.78|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.89|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.89|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.93|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|2.03|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.1|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.15|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.17|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.18|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:w:wdr20|WDR20]]|0.571|
|[[:human genes:u:usp46|USP46]]|0.464|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 48/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|1/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|7/21|
|liver|1/20|
|lung|10/75|
|lymphocyte|0/16|
|ovary|4/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR48 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>