======= WDR73 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR73
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 73
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84942|84942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P4I2|Q6P4I2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR73&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR73|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283). {ECO:0000269|PubMed:25466283}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoplasmic microtubule organization|
|cleavage furrow|
|spindle pole|
|nucleus organization|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|microtubule-based process|
|molecular function|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|negative regulation of cell death|
|cytoskeleton organization|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.62|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.1|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 136/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|10/28|
|blood|0/28|
|bone|6/26|
|breast|7/33|
|central nervous system|13/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|7/21|
|liver|7/20|
|lung|16/75|
|lymphocyte|2/16|
|ovary|5/26|
|pancreas|5/24|
|peripheral nervous system|1/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4389
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR73 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>