======= WDR75 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR75
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 75
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84128|84128]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWA0|Q8IWA0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR75&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR75|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620341|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre- ribosomal RNA transcription by RNA polymerase I. {ECO:0000269|PubMed:17699751}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of rRNA processing|
|positive regulation of ribosome biogenesis|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|positive regulation of transcription by RNA polymerase I|
|regulation of transcription by RNA polymerase I|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|positive regulation of cellular component biogenesis|
|nucleolus|
|RNA processing|
|regulation of cellular component biogenesis|
|RNA binding|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.33|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.13|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.82|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.76|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.75|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.75|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.7|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.7|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.72|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.74|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.78|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.82|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.82|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.84|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.88|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.92|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.98|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.19|
|[[:results:exp187|proTAME 5μM R04 exp187]]|2.3|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.32|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.36|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.52|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|2.56|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.702|
|[[:human genes:p:prim1|PRIM1]]|0.616|
|[[:human genes:p:psmb4|PSMB4]]|0.527|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.527|
|[[:human genes:r:rpl35|RPL35]]|0.511|
|[[:human genes:t:tceb3c|TCEB3C]]|0.511|
|[[:human genes:p:psmb2|PSMB2]]|0.504|
|[[:human genes:c:cbwd3|CBWD3]]|0.501|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.498|
|[[:human genes:e:exosc9|EXOSC9]]|0.494|
|[[:human genes:t:ticrr|TICRR]]|0.493|
|[[:human genes:c:cbwd6|CBWD6]]|0.49|
|[[:human genes:c:cgb2|CGB2]]|0.489|
|[[:human genes:e:exosc6|EXOSC6]]|0.486|
|[[:human genes:c:cbwd5|CBWD5]]|0.485|
|[[:human genes:u:upf1|UPF1]]|0.484|
|[[:human genes:n:npipb5|NPIPB5]]|0.484|
|[[:human genes:s:sf3a3|SF3A3]]|0.482|
|[[:human genes:d:dimt1|DIMT1]]|0.479|
|[[:human genes:c:cdc45|CDC45]]|0.473|
|[[:human genes:p:psma6|PSMA6]]|0.473|
|[[:human genes:u:utp20|UTP20]]|0.473|
|[[:human genes:t:twistnb|TWISTNB]]|0.472|
|[[:human genes:h:hivep3|HIVEP3]]|0.47|
|[[:human genes:a:aatf|AATF]]|0.469|
|[[:human genes:p:pole|POLE]]|0.467|
|[[:human genes:s:supt6h|SUPT6H]]|0.466|
|[[:human genes:p:polr2d|POLR2D]]|0.466|
|[[:human genes:g:golga8o|GOLGA8O]]|0.464|
|[[:human genes:s:sart1|SART1]]|0.462|
|[[:human genes:c:chd4|CHD4]]|0.461|
|[[:human genes:i:ik|IK]]|0.458|
|[[:human genes:r:rrp7a|RRP7A]]|0.453|
|[[:human genes:a:ankle2|ANKLE2]]|0.453|
|[[:human genes:a:akirin2|AKIRIN2]]|0.453|
|[[:human genes:s:sf3a1|SF3A1]]|0.452|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.452|
|[[:human genes:c:ctage4|CTAGE4]]|0.451|
|[[:human genes:d:ddtl|DDTL]]|0.45|
|[[:human genes:p:pola1|POLA1]]|0.448|
|[[:human genes:k:kiaa0947|KIAA0947]]|0.448|
|[[:human genes:p:pola2|POLA2]]|0.448|
|[[:human genes:s:snip1|SNIP1]]|0.447|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.446|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.446|
|[[:human genes:c:col2a1|COL2A1]]|0.446|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.446|
|[[:human genes:r:rps12|RPS12]]|0.445|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.445|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.444|
|[[:human genes:t:tyms|TYMS]]|0.443|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.441|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.441|
|[[:human genes:s:supt5h|SUPT5H]]|0.441|
|[[:human genes:p:ppm1d|PPM1D]]|0.44|
|[[:human genes:r:rps2|RPS2]]|0.44|
|[[:human genes:g:gprin2|GPRIN2]]|0.439|
|[[:human genes:r:rrn3|RRN3]]|0.438|
|[[:human genes:b:bysl|BYSL]]|0.438|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.436|
|[[:human genes:p:polr2h|POLR2H]]|0.436|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.436|
|[[:human genes:t:tspy1|TSPY1]]|0.436|
|[[:human genes:n:napa|NAPA]]|0.436|
|[[:human genes:n:nup160|NUP160]]|0.435|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.435|
|[[:human genes:p:psmc5|PSMC5]]|0.434|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.434|
|[[:human genes:d:ddx47|DDX47]]|0.433|
|[[:human genes:c:ccdc116|CCDC116]]|0.432|
|[[:human genes:m:mfsd12|MFSD12]]|0.431|
|[[:human genes:d:dtl|DTL]]|0.431|
|[[:human genes:t:traip|TRAIP]]|0.428|
|[[:human genes:r:rps7|RPS7]]|0.427|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.426|
|[[:human genes:n:nol9|NOL9]]|0.426|
|[[:human genes:l:lrr1|LRR1]]|0.426|
|[[:human genes:p:psmd3|PSMD3]]|0.425|
|[[:human genes:p:psmd7|PSMD7]]|0.425|
|[[:human genes:c:cope|COPE]]|0.424|
|[[:human genes:s:smg1|SMG1]]|0.424|
|[[:human genes:s:slc6a17|SLC6A17]]|0.422|
|[[:human genes:p:paf1|PAF1]]|0.422|
|[[:human genes:r:rnf113a|RNF113A]]|0.422|
|[[:human genes:c:cdc73|CDC73]]|0.421|
|[[:human genes:t:tspy8|TSPY8]]|0.421|
|[[:human genes:n:nfatc4|NFATC4]]|0.42|
|[[:human genes:p:psmb1|PSMB1]]|0.419|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.419|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.419|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.419|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.419|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.418|
|[[:human genes:n:nol12|NOL12]]|0.418|
|[[:human genes:p:pold1|POLD1]]|0.418|
|[[:human genes:r:rad51|RAD51]]|0.418|
|[[:human genes:t:tfip11|TFIP11]]|0.418|
|[[:human genes:x:xab2|XAB2]]|0.417|
|[[:human genes:b:brix1|BRIX1]]|0.416|
|[[:human genes:m:myo1h|MYO1H]]|0.416|
|[[:human genes:p:pan2|PAN2]]|0.415|
|[[:human genes:t:taf1|TAF1]]|0.415|
|[[:human genes:g:golga8j|GOLGA8J]]|0.413|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.413|
|[[:human genes:p:psap|PSAP]]|0.412|
|[[:human genes:k:krt78|KRT78]]|0.412|
|[[:human genes:c:cyb561a3|CYB561A3]]|0.412|
|[[:human genes:m:med17|MED17]]|0.411|
|[[:human genes:m:mepce|MEPCE]]|0.41|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.409|
|[[:human genes:k:kctd17|KCTD17]]|0.409|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.409|
|[[:human genes:c:cdc6|CDC6]]|0.408|
|[[:human genes:n:nsf|NSF]]|0.408|
|[[:human genes:p:psma7|PSMA7]]|0.407|
|[[:human genes:n:nufip2|NUFIP2]]|0.405|
|[[:human genes:p:psmd1|PSMD1]]|0.405|
|[[:human genes:a:arcn1|ARCN1]]|0.405|
|[[:human genes:c:ctage9|CTAGE9]]|0.405|
|[[:human genes:c:c14orf93|C14orf93]]|0.405|
|[[:human genes:p:psmc2|PSMC2]]|0.405|
|[[:human genes:c:copb1|COPB1]]|0.404|
|[[:human genes:c:cep192|CEP192]]|0.404|
|[[:human genes:l:lad1|LAD1]]|0.403|
|[[:human genes:p:polr2a|POLR2A]]|0.403|
|[[:human genes:k:kpnb1|KPNB1]]|0.402|
|[[:human genes:r:rrp15|RRP15]]|0.402|
|[[:human genes:v:vps28|VPS28]]|0.402|
|[[:human genes:c:ccna2|CCNA2]]|0.402|
|[[:human genes:n:ngdn|NGDN]]|0.401|
|[[:human genes:p:psmd11|PSMD11]]|0.401|
|[[:human genes:p:psmc6|PSMC6]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 732/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 436
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR75 Expression in NALM6 Cells: 6.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>