======= WDR77 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WDR77
  * **<color #00a2e8>Official Name</color>**: WD repeat domain 77
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79084|79084]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BQA1|Q9BQA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WDR77&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WDR77|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611734|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. {ECO:0000269|PubMed:11756452, ECO:0000269|PubMed:23071334}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|
|negative regulation of epithelial cell proliferation involved in prostate gland development|
|regulation of epithelial cell proliferation involved in prostate gland development|
|prostate glandular acinus development|
|methylosome|
|epithelial cell differentiation involved in prostate gland development|
|methyl-CpG binding|
|spliceosomal snRNP assembly|
|glandular epithelial cell differentiation|
|prostate gland development|
|negative regulation of reproductive process|
|nuclear receptor transcription coactivator activity|
|columnar/cuboidal epithelial cell differentiation|
|negative regulation of epithelial cell proliferation|
|regulation of reproductive process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|urogenital system development|
|regulation of epithelial cell proliferation|
|RNA splicing|
|gland development|
|reproductive structure development|
|reproductive system development|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|Golgi apparatus|
|epithelium development|
|negative regulation of multicellular organismal process|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|RNA metabolic process|
|positive regulation of RNA metabolic process|
|tissue development|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.47|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.21|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|-1.89|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.75|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.8|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.96|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.98|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.06|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.13|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|2.33|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|3.48|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:snapc5|SNAPC5]]|0.424|
|[[:human genes:c:cd2bp2|CD2BP2]]|0.416|
|[[:human genes:p:ppp4c|PPP4C]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 674/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|28/28|
|bone|25/25|
|breast|29/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|18/21|
|liver|20/20|
|lung|67/75|
|lymphocyte|14/14|
|ovary|23/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|0/1|
|skin|21/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 431
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WDR77 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>