======= WHAMM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WHAMM
  * **<color #00a2e8>Official Name</color>**: WASP homolog associated with actin, golgi membranes and microtubules
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=123720|123720]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TF30|Q8TF30]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WHAMM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WHAMM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612393|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule- binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration. {ECO:0000269|PubMed:18614018, ECO:0000269|PubMed:23027905, ECO:0000269|PubMed:23087206}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament reorganization|
|Arp2/3 complex binding|
|positive regulation of actin nucleation|
|plasma membrane tubulation|
|GTP-Rho binding|
|Arp2/3 complex-mediated actin nucleation|
|regulation of actin nucleation|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|actin nucleation|
|lamellipodium assembly|
|adherens junction assembly|
|lamellipodium organization|
|cell-substrate junction assembly|
|actin cytoskeleton reorganization|
|endoplasmic reticulum-Golgi intermediate compartment membrane|
|adherens junction organization|
|positive regulation of actin filament polymerization|
|plasma membrane organization|
|cell-matrix adhesion|
|positive regulation of protein polymerization|
|cytoplasmic vesicle membrane|
|cell cycle arrest|
|regulation of actin filament polymerization|
|cell junction assembly|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|cell-substrate adhesion|
|positive regulation of supramolecular fiber organization|
|cell junction organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|positive regulation of cytoskeleton organization|
|regulation of protein polymerization|
|microtubule binding|
|actin filament organization|
|positive regulation of protein complex assembly|
|regulation of actin filament organization|
|actin binding|
|microtubule|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|Golgi vesicle transport|
|regulation of cellular component size|
|regulation of actin filament-based process|
|endomembrane system organization|
|plasma membrane bounded cell projection assembly|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|cell projection assembly|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|positive regulation of cellular component biogenesis|
|regulation of cytoskeleton organization|
|actin filament-based process|
|negative regulation of cell cycle|
|Golgi membrane|
|positive regulation of organelle organization|
|membrane organization|
|cell adhesion|
|biological adhesion|
|regulation of cellular component biogenesis|
|cell cycle process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WHAMM Expression in NALM6 Cells: 5.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>