======= WISP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CCN4
  * **<color #00a2e8>Official Name</color>**: cellular communication network factor 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8840|8840]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95388|O95388]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WISP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WISP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603398|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. {ECO:0000269|PubMed:10716946, ECO:0000269|PubMed:11782444}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|VWC|
|TSP 1|
|Cys knot|
|IGFBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|insulin-like growth factor binding|
|negative regulation of chondrocyte differentiation|
|negative regulation of cartilage development|
|positive regulation of smooth muscle cell migration|
|osteoclast differentiation|
|negative regulation of fat cell differentiation|
|regulation of chondrocyte differentiation|
|positive regulation of wound healing|
|positive regulation of osteoblast differentiation|
|regulation of smooth muscle cell migration|
|positive regulation of response to wounding|
|regulation of cartilage development|
|positive regulation of ossification|
|positive regulation of smooth muscle cell proliferation|
|myeloid leukocyte differentiation|
|regulation of osteoblast differentiation|
|regulation of fat cell differentiation|
|osteoblast differentiation|
|integrin binding|
|regulation of smooth muscle cell proliferation|
|regulation of wound healing|
|positive regulation of inflammatory response|
|regulation of response to wounding|
|heparin binding|
|positive regulation of Wnt signaling pathway|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of ossification|
|bone development|
|regulation of cytokine secretion|
|myeloid cell differentiation|
|extracellular matrix|
|ossification|
|leukocyte differentiation|
|regulation of inflammatory response|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of peptide secretion|
|skeletal system development|
|positive regulation of cell migration|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|hemopoiesis|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|immune system development|
|regulation of cytokine production|
|regulation of protein transport|
|negative regulation of cell differentiation|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|regulation of protein localization|
|regulation of response to external stimulus|
|chemical homeostasis|
|cell-cell signaling|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|regulation of response to stress|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18554
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WISP1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>