======= WNK3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNK3
  * **<color #00a2e8>Official Name</color>**: WNK lysine deficient protein kinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65267|65267]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BYP7|Q9BYP7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNK3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNK3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300358|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|OSR1 C|
|Pkinase|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of pancreatic juice secretion|
|regulation of pancreatic juice secretion|
|positive regulation of potassium ion import across plasma membrane|
|potassium channel inhibitor activity|
|regulation of potassium ion import|
|chloride channel inhibitor activity|
|positive regulation of sodium ion transmembrane transporter activity|
|negative regulation of sodium ion transport|
|negative regulation of digestive system process|
|positive regulation of sodium ion transmembrane transport|
|positive regulation of peptidyl-threonine phosphorylation|
|positive regulation of sodium ion transport|
|positive regulation of potassium ion transmembrane transport|
|regulation of calcium ion import|
|regulation of digestive system process|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of potassium ion transport|
|regulation of sodium ion transmembrane transporter activity|
|positive regulation of protein localization to plasma membrane|
|positive regulation of protein localization to cell periphery|
|adherens junction|
|regulation of sodium ion transmembrane transport|
|regulation of potassium ion transmembrane transport|
|regulation of sodium ion transport|
|regulation of protein localization to plasma membrane|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|regulation of protein localization to cell periphery|
|positive regulation of calcium ion transport|
|positive regulation of protein localization to membrane|
|bicellular tight junction|
|positive regulation of cation transmembrane transport|
|negative regulation of ion transport|
|positive regulation of ion transmembrane transport|
|protein localization to plasma membrane|
|regulation of protein localization to membrane|
|protein autophosphorylation|
|positive regulation of transmembrane transport|
|protein localization to cell periphery|
|negative regulation of secretion|
|protein kinase activity|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|protein serine/threonine kinase activity|
|regulation of metal ion transport|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|negative regulation of transport|
|regulation of body fluid levels|
|regulation of cellular protein localization|
|regulation of transmembrane transport|
|regulation of system process|
|regulation of ion transport|
|ion homeostasis|
|regulation of secretion|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|protein phosphorylation|
|positive regulation of transport|
|negative regulation of cell death|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of protein phosphorylation|
|ATP binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.82|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|1.94|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16206
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.41 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNK3 Expression in NALM6 Cells: 1.41'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>