======= WNK4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNK4
  * **<color #00a2e8>Official Name</color>**: WNK lysine deficient protein kinase 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=65266|65266]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96J92|Q96J92]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNK4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNK4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601844|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
|OSR1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|distal tubule morphogenesis|
|renal sodium ion absorption|
|negative regulation of pancreatic juice secretion|
|renal sodium ion transport|
|regulation of pancreatic juice secretion|
|positive regulation of potassium ion import across plasma membrane|
|regulation of potassium ion import|
|potassium channel inhibitor activity|
|chloride channel inhibitor activity|
|distal tubule development|
|renal absorption|
|positive regulation of sodium ion transmembrane transporter activity|
|negative regulation of sodium ion transport|
|negative regulation of digestive system process|
|positive regulation of sodium ion transmembrane transport|
|positive regulation of sodium ion transport|
|positive regulation of potassium ion transmembrane transport|
|regulation of digestive system process|
|positive regulation of potassium ion transport|
|regulation of sodium ion transmembrane transporter activity|
|regulation of sodium ion transmembrane transport|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|renal tubule morphogenesis|
|nephron tubule development|
|regulation of potassium ion transmembrane transport|
|renal tubule development|
|kidney morphogenesis|
|regulation of sodium ion transport|
|regulation of potassium ion transport|
|nephron epithelium development|
|chloride transport|
|positive regulation of ion transmembrane transporter activity|
|renal system process|
|positive regulation of transporter activity|
|bicellular tight junction|
|nephron development|
|kidney epithelium development|
|positive regulation of cation transmembrane transport|
|negative regulation of ion transport|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|inorganic anion transport|
|positive regulation of transmembrane transport|
|negative regulation of secretion|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|kidney development|
|positive regulation of ion transport|
|regulation of transporter activity|
|renal system development|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of cation transmembrane transport|
|protein serine/threonine kinase activity|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|morphogenesis of an epithelium|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of body fluid levels|
|regulation of transmembrane transport|
|tissue morphogenesis|
|anion transport|
|regulation of system process|
|metal ion transport|
|tube morphogenesis|
|regulation of ion transport|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|tube development|
|animal organ morphogenesis|
|protein phosphorylation|
|positive regulation of transport|
|chemical homeostasis|
|epithelium development|
|negative regulation of multicellular organismal process|
|phosphorylation|
|ion transport|
|ATP binding|
|homeostatic process|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.77|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.74|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4956
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNK4 Expression in NALM6 Cells: 1.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>