======= WNT11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT11
  * **<color #00a2e8>Official Name</color>**: Wnt family member 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7481|7481]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O96014|O96014]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603699|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of transforming growth factor beta2 production|
|planar cell polarity pathway involved in gastrula mediolateral intercalation|
|mediolateral intercalation|
|cloacal septation|
|negative regulation of fibroblast growth factor production|
|planar cell polarity pathway involved in axis elongation|
|cloaca development|
|convergent extension involved in axis elongation|
|neuroendocrine cell differentiation|
|paraxial mesoderm formation|
|regulation of transforming growth factor beta2 production|
|lung-associated mesenchyme development|
|convergent extension involved in gastrulation|
|negative regulation of mesenchymal cell proliferation|
|regulation of fibroblast growth factor production|
|mesonephric duct development|
|positive regulation of protein kinase C signaling|
|notochord morphogenesis|
|paraxial mesoderm morphogenesis|
|maintenance of apical/basal cell polarity|
|maintenance of epithelial cell apical/basal polarity|
|convergent extension|
|cell migration involved in gastrulation|
|regulation of protein kinase C signaling|
|nephric duct development|
|maintenance of cell polarity|
|paraxial mesoderm development|
|positive regulation of transforming growth factor beta production|
|notochord development|
|secondary palate development|
|adrenal gland development|
|protein localization to cell surface|
|protein kinase activator activity|
|axis elongation|
|negative regulation of cartilage development|
|regulation of mesenchymal cell proliferation|
|regulation of transforming growth factor beta production|
|bicellular tight junction assembly|
|tight junction assembly|
|Wnt signaling pathway, calcium modulating pathway|
|tight junction organization|
|frizzled binding|
|ventricular septum morphogenesis|
|neuroepithelial cell differentiation|
|apical junction assembly|
|establishment or maintenance of epithelial cell apical/basal polarity|
|digestive tract morphogenesis|
|bone mineralization|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|mesenchyme morphogenesis|
|positive regulation of stress fiber assembly|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|positive regulation of actin filament bundle assembly|
|artery morphogenesis|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|mesoderm formation|
|renal tubule morphogenesis|
|cellular response to retinoic acid|
|mesoderm morphogenesis|
|regulation of cartilage development|
|epithelial to mesenchymal transition|
|ventricular septum development|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|nephron tubule development|
|cellular response to mechanical stimulus|
|regulation of stress fiber assembly|
|renal tubule development|
|somite development|
|kidney morphogenesis|
|ureteric bud development|
|artery development|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of actomyosin structure organization|
|roof of mouth development|
|canonical Wnt signaling pathway|
|mesonephros development|
|biomineralization|
|regulation of actin filament bundle assembly|
|biomineral tissue development|
|columnar/cuboidal epithelial cell differentiation|
|Wnt signaling pathway, planar cell polarity pathway|
|nephron epithelium development|
|cell-cell junction assembly|
|response to retinoic acid|
|cardiac septum development|
|formation of primary germ layer|
|regulation of establishment of planar polarity|
|developmental growth involved in morphogenesis|
|endocrine system development|
|mesoderm development|
|nephron development|
|cardiac chamber morphogenesis|
|embryonic skeletal system development|
|osteoblast differentiation|
|cardiac ventricle development|
|kidney epithelium development|
|digestive tract development|
|non-canonical Wnt signaling pathway|
|cell-cell junction organization|
|digestive system development|
|cytokine production|
|mesenchymal cell differentiation|
|gastrulation|
|cell junction assembly|
|lung development|
|cardiac chamber development|
|ameboidal-type cell migration|
|respiratory tube development|
|negative regulation of canonical Wnt signaling pathway|
|regulation of morphogenesis of an epithelium|
|negative regulation of cell growth|
|respiratory system development|
|establishment or maintenance of cell polarity|
|positive regulation of supramolecular fiber organization|
|cellular response to acid chemical|
|negative regulation of Wnt signaling pathway|
|response to mechanical stimulus|
|cell junction organization|
|transcription regulatory region DNA binding|
|positive regulation of cytoskeleton organization|
|mesenchyme development|
|extracellular matrix|
|negative regulation of growth|
|cell fate commitment|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|regulation of actin filament organization|
|ossification|
|kidney development|
|negative regulation of cytokine production|
|negative regulation of cell motility|
|GTPase activator activity|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|urogenital system development|
|negative regulation of locomotion|
|activation of protein kinase activity|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|response to acid chemical|
|regulation of supramolecular fiber organization|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|gland development|
|positive regulation of GTPase activity|
|regulation of cell growth|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|positive regulation of cytokine production|
|regulation of GTPase activity|
|blood vessel development|
|skeletal system development|
|response to nutrient levels|
|positive regulation of cell migration|
|vasculature development|
|cardiovascular system development|
|positive regulation of cellular component biogenesis|
|cellular response to lipid|
|positive regulation of cell motility|
|heart development|
|response to extracellular stimulus|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of kinase activity|
|positive regulation of organelle organization|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of growth|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|regulation of cytokine production|
|positive regulation of cell death|
|positive regulation of hydrolase activity|
|regulation of protein kinase activity|
|tube development|
|regulation of cell migration|
|response to lipid|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.472|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16161
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT11 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>