======= WNT16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT16
  * **<color #00a2e8>Official Name</color>**: Wnt family member 16
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51384|51384]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBV4|Q9UBV4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|optic cup formation involved in camera-type eye development|
|oxidative stress-induced premature senescence|
|optic cup morphogenesis involved in camera-type eye development|
|stress-induced premature senescence|
|keratinocyte proliferation|
|embryonic camera-type eye formation|
|replicative senescence|
|embryonic camera-type eye morphogenesis|
|cardiac epithelial to mesenchymal transition|
|cellular senescence|
|embryonic eye morphogenesis|
|embryonic camera-type eye development|
|frizzled binding|
|bone remodeling|
|cell aging|
|epithelial to mesenchymal transition|
|positive regulation of phosphatidylinositol 3-kinase signaling|
|epithelial cell proliferation|
|tissue remodeling|
|camera-type eye morphogenesis|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of JNK cascade|
|morphogenesis of embryonic epithelium|
|eye morphogenesis|
|mesenchymal cell differentiation|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|regulation of JNK cascade|
|mesenchyme development|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|cell fate commitment|
|heart morphogenesis|
|sensory organ morphogenesis|
|keratinocyte differentiation|
|aging|
|embryonic organ morphogenesis|
|camera-type eye development|
|epidermal cell differentiation|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|sensory system development|
|skin development|
|response to oxidative stress|
|epidermis development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|morphogenesis of an epithelium|
|embryonic organ development|
|heart development|
|positive regulation of MAPK cascade|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|epithelial cell differentiation|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|extracellular region|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.95|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.512|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13881
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT16 Expression in NALM6 Cells: -2.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>