======= WNT4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT4
  * **<color #00a2e8>Official Name</color>**: Wnt family member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54361|54361]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P56705|P56705]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603490|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immature T cell proliferation|
|negative regulation of male gonad development|
|positive regulation of glucocorticoid biosynthetic process|
|positive regulation of glucocorticoid metabolic process|
|negative regulation of testicular blood vessel morphogenesis|
|positive regulation of cortisol biosynthetic process|
|negative regulation of androgen biosynthetic process|
|immature T cell proliferation in thymus|
|negative regulation of testosterone biosynthetic process|
|female sex determination|
|positive regulation of aldosterone metabolic process|
|positive regulation of aldosterone biosynthetic process|
|regulation of testosterone biosynthetic process|
|thyroid-stimulating hormone-secreting cell differentiation|
|tertiary branching involved in mammary gland duct morphogenesis|
|positive regulation of dermatome development|
|renal vesicle induction|
|positive regulation of steroid hormone biosynthetic process|
|regulation of dermatome development|
|paramesonephric duct development|
|somatotropin secreting cell differentiation|
|metanephric mesenchymal cell differentiation|
|regulation of cortisol biosynthetic process|
|mammary gland branching involved in pregnancy|
|negative regulation of gonad development|
|renal vesicle formation|
|non-canonical Wnt signaling pathway via MAPK cascade|
|metanephric tubule formation|
|regulation of aldosterone biosynthetic process|
|regulation of aldosterone metabolic process|
|regulation of glucocorticoid biosynthetic process|
|neuroendocrine cell differentiation|
|mesenchymal cell differentiation involved in renal system development|
|mesenchymal cell differentiation involved in kidney development|
|regulation of glucocorticoid metabolic process|
|regulation of male gonad development|
|negative regulation of hormone biosynthetic process|
|regulation of steroid hormone biosynthetic process|
|positive regulation of hormone biosynthetic process|
|metanephric tubule morphogenesis|
|negative regulation of hormone metabolic process|
|renal vesicle morphogenesis|
|adenohypophysis development|
|renal vesicle development|
|positive regulation of meiotic nuclear division|
|metanephric mesenchyme development|
|positive regulation of hormone metabolic process|
|mesenchymal to epithelial transition|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|regulation of ketone biosynthetic process|
|cell differentiation involved in metanephros development|
|kidney mesenchyme development|
|metanephric tubule development|
|positive regulation of steroid biosynthetic process|
|regulation of gonad development|
|metanephric nephron morphogenesis|
|metanephric epithelium development|
|sex determination|
|branching involved in mammary gland duct morphogenesis|
|negative regulation of steroid biosynthetic process|
|positive regulation of meiotic cell cycle|
|positive regulation of focal adhesion assembly|
|adrenal gland development|
|negative regulation of steroid metabolic process|
|positive regulation of collagen biosynthetic process|
|positive regulation of alcohol biosynthetic process|
|positive regulation of collagen metabolic process|
|positive regulation of steroid metabolic process|
|regulation of hormone biosynthetic process|
|metanephros morphogenesis|
|developmental induction|
|regulation of fibroblast growth factor receptor signaling pathway|
|metanephric nephron development|
|regulation of meiotic nuclear division|
|positive regulation of adherens junction organization|
|mammary gland duct morphogenesis|
|smooth muscle cell differentiation|
|receptor ligand activity|
|positive regulation of cell junction assembly|
|positive regulation of morphogenesis of an epithelium|
|regulation of collagen biosynthetic process|
|positive regulation of embryonic development|
|regulation of hormone metabolic process|
|oocyte development|
|T cell proliferation|
|glandular epithelial cell differentiation|
|positive regulation of bone mineralization|
|positive regulation of kidney development|
|regulation of collagen metabolic process|
|frizzled binding|
|cell differentiation involved in kidney development|
|pituitary gland development|
|mammary gland morphogenesis|
|oocyte differentiation|
|neuroepithelial cell differentiation|
|branching involved in ureteric bud morphogenesis|
|positive regulation of biomineralization|
|T cell differentiation in thymus|
|positive regulation of biomineral tissue development|
|regulation of meiotic cell cycle|
|negative regulation of lipid biosynthetic process|
|positive regulation of stress fiber assembly|
|positive regulation of cell-matrix adhesion|
|ureteric bud morphogenesis|
|mesonephric tubule morphogenesis|
|regulation of kidney development|
|negative regulation of reproductive process|
|mammary gland epithelium development|
|positive regulation of osteoblast differentiation|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|positive regulation of actin filament bundle assembly|
|maternal process involved in female pregnancy|
|nephron tubule morphogenesis|
|nephron epithelium morphogenesis|
|positive regulation of nuclear division|
|regulation of adherens junction organization|
|nephron morphogenesis|
|endocytic vesicle membrane|
|renal tubule morphogenesis|
|epithelial to mesenchymal transition|
|negative regulation of wound healing|
|regulation of alcohol biosynthetic process|
|regulation of bone mineralization|
|diencephalon development|
|nephron tubule development|
|oogenesis|
|positive regulation of reproductive process|
|positive regulation of lipid biosynthetic process|
|regulation of stress fiber assembly|
|renal tubule development|
|positive regulation of animal organ morphogenesis|
|negative regulation of lipid metabolic process|
|lymphocyte proliferation|
|metanephros development|
|kidney morphogenesis|
|positive regulation of ossification|
|ureteric bud development|
|mononuclear cell proliferation|
|negative regulation of response to wounding|
|mesonephric epithelium development|
|mesonephric tubule development|
|regulation of steroid biosynthetic process|
|female gonad development|
|regulation of actomyosin structure organization|
|regulation of cell junction assembly|
|canonical Wnt signaling pathway|
|mesonephros development|
|negative regulation of small molecule metabolic process|
|regulation of actin filament bundle assembly|
|regulation of biomineralization|
|development of primary female sexual characteristics|
|regulation of biomineral tissue development|
|columnar/cuboidal epithelial cell differentiation|
|nephron epithelium development|
|leukocyte proliferation|
|gland morphogenesis|
|Golgi lumen|
|negative regulation of blood vessel morphogenesis|
|female sex differentiation|
|regulation of osteoblast differentiation|
|regulation of cell-matrix adhesion|
|regulation of steroid metabolic process|
|negative regulation of vasculature development|
|positive regulation of cell-substrate adhesion|
|endocrine system development|
|embryonic epithelial tube formation|
|nephron development|
|liver development|
|mammary gland development|
|kidney epithelium development|
|regulation of embryonic development|
|hepaticobiliary system development|
|female gamete generation|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|male gonad development|
|non-canonical Wnt signaling pathway|
|T cell differentiation|
|development of primary male sexual characteristics|
|positive regulation of small molecule metabolic process|
|regulation of wound healing|
|positive regulation of lipid metabolic process|
|morphogenesis of embryonic epithelium|
|negative regulation of cellular response to growth factor stimulus|
|tube formation|
|cellular response to starvation|
|cellular response to transforming growth factor beta stimulus|
|male sex differentiation|
|mesenchymal cell differentiation|
|morphogenesis of a branching epithelium|
|regulation of reproductive process|
|response to transforming growth factor beta|
|regulation of response to wounding|
|morphogenesis of a branching structure|
|regulation of cellular ketone metabolic process|
|regulation of morphogenesis of an epithelium|
|female pregnancy|
|regulation of lipid biosynthetic process|
|regulation of ossification|
|regulation of nuclear division|
|response to starvation|
|positive regulation of supramolecular fiber organization|
|hormone metabolic process|
|gonad development|
|regulation of cell-substrate adhesion|
|multi-multicellular organism process|
|development of primary sexual characteristics|
|positive regulation of cytoskeleton organization|
|mesenchyme development|
|negative regulation of apoptotic signaling pathway|
|extracellular matrix|
|cellular response to nutrient levels|
|T cell activation|
|lymphocyte differentiation|
|transcription corepressor activity|
|muscle cell differentiation|
|cell fate commitment|
|germ cell development|
|regulation of animal organ morphogenesis|
|negative regulation of cell migration|
|regulation of actin filament organization|
|cellular response to extracellular stimulus|
|sex differentiation|
|kidney development|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|renal system development|
|positive regulation of cell cycle process|
|endoplasmic reticulum lumen|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|leukocyte differentiation|
|cellular response to external stimulus|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cellular process involved in reproduction in multicellular organism|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|negative regulation of response to external stimulus|
|positive regulation of cell cycle|
|lymphocyte activation|
|forebrain development|
|regulation of actin filament-based process|
|regulation of lipid metabolic process|
|regulation of apoptotic signaling pathway|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|gland development|
|positive regulation of GTPase activity|
|reproductive structure development|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|morphogenesis of an epithelium|
|muscle structure development|
|regulation of GTPase activity|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|response to growth factor|
|regulation of hormone levels|
|regulation of cytoskeleton organization|
|cell population proliferation|
|hemopoiesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|cell surface|
|positive regulation of organelle organization|
|immune system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|epithelial cell differentiation|
|gamete generation|
|negative regulation of cell differentiation|
|brain development|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|leukocyte activation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|negative regulation of cell death|
|multi-organism reproductive process|
|regulation of cellular component movement|
|neuron differentiation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|regulation of response to external stimulus|
|epithelium development|
|cell-cell signaling|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.87|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.8|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|2.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4085
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT4 Expression in NALM6 Cells: 0.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>