======= WNT5A =======
== Gene Information ==
* **Official Symbol**: WNT5A
* **Official Name**: Wnt family member 5A
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7474|7474]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P41221|P41221]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=WNT5A&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT5A|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/164975|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
* **UniProt Summary**: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity). {ECO:0000250|UniProtKB:P22725, ECO:0000250|UniProtKB:Q27Q52, ECO:0000269|PubMed:15735754, ECO:0000269|PubMed:17426020}.
|wnt|
|chemoattraction of serotonergic neuron axon|
|receptor tyrosine kinase-like orphan receptor binding|
|planar cell polarity pathway involved in cardiac muscle tissue morphogenesis|
|planar cell polarity pathway involved in ventricular septum morphogenesis|
|planar cell polarity pathway involved in outflow tract morphogenesis|
|negative regulation of cell proliferation in midbrain|
|planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation|
|planar cell polarity pathway involved in cardiac right atrium morphogenesis|
|planar cell polarity pathway involved in pericardium morphogenesis|
|mesodermal to mesenchymal transition involved in gastrulation|
|planar cell polarity pathway involved in gastrula mediolateral intercalation|
|cervix development|
|chemorepulsion of dopaminergic neuron axon|
|mediolateral intercalation|
|positive regulation of timing of anagen|
|chemoattractant activity involved in axon guidance|
|non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|regulation of cell proliferation in midbrain|
|hypophysis morphogenesis|
|non-canonical Wnt signaling pathway involved in heart development|
|lateral sprouting involved in mammary gland duct morphogenesis|
|planar cell polarity pathway involved in heart morphogenesis|
|cardiac right atrium morphogenesis|
|negative regulation of melanin biosynthetic process|
|diencephalon morphogenesis|
|optic cup formation involved in camera-type eye development|
|negative regulation of secondary metabolite biosynthetic process|
|melanocyte proliferation|
|planar cell polarity pathway involved in axis elongation|
|urinary bladder development|
|chemoattraction of axon|
|serotonergic neuron axon guidance|
|epithelial cell proliferation involved in mammary gland duct elongation|
|negative regulation of prostatic bud formation|
|regulation of branching involved in mammary gland duct morphogenesis|
|positive regulation of thymocyte apoptotic process|
|Wnt signaling pathway involved in heart development|
|positive regulation of hair follicle maturation|
|planar cell polarity pathway involved in axon guidance|
|positive regulation of protein kinase C activity|
|mammary gland branching involved in thelarche|
|dopaminergic neuron axon guidance|
|non-canonical Wnt signaling pathway via JNK cascade|
|regulation of timing of anagen|
|thelarche|
|regulation of protein kinase C activity|
|branch elongation involved in mammary gland duct branching|
|regulation of prostatic bud formation|
|chemorepulsion of axon|
|development of secondary female sexual characteristics|
|convergent extension involved in axis elongation|
|convergent extension involved in organogenesis|
|non-canonical Wnt signaling pathway via MAPK cascade|
|hindgut morphogenesis|
|negative regulation of synapse assembly|
|paraxial mesoderm formation|
|mesenchymal-epithelial cell signaling|
|optic cup morphogenesis involved in camera-type eye development|
|hindgut development|
|positive regulation of neuron projection arborization|
|positive regulation of cytokine secretion involved in immune response|
|convergent extension involved in gastrulation|
|negative regulation of mesenchymal cell proliferation|
|development of secondary sexual characteristics|
|lateral sprouting from an epithelium|
|pericardium morphogenesis|
|regulation of hair follicle maturation|
|positive regulation of macrophage cytokine production|
|olfactory bulb interneuron development|
|inhibitory synapse assembly|
|positive regulation of cell-cell adhesion mediated by cadherin|
|Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation|
|positive regulation of protein kinase C signaling|
|regulation of neuron projection arborization|
|paraxial mesoderm morphogenesis|
|primitive streak formation|
|vagina development|
|notochord morphogenesis|
|positive regulation of protein localization to synapse|
|regulation of melanin biosynthetic process|
|regulation of secondary metabolite biosynthetic process|
|forebrain morphogenesis|
|positive regulation of chemokine biosynthetic process|
|regulation of thymocyte apoptotic process|
|regulation of postsynaptic cytosolic calcium ion concentration|
|mammary gland epithelial cell proliferation|
|positive regulation of hair follicle development|
|embryonic camera-type eye formation|
|midbrain dopaminergic neuron differentiation|
|hematopoietic stem cell proliferation|
|midgut development|
|positive regulation of type I interferon-mediated signaling pathway|
|regulation of secondary metabolic process|
|positive regulation of hair cycle|
|planar cell polarity pathway involved in neural tube closure|
|positive regulation of non-canonical Wnt signaling pathway|
|convergent extension|
|positive regulation of T cell apoptotic process|
|positive regulation of meiotic nuclear division|
|olfactory bulb interneuron differentiation|
|regulation of macrophage cytokine production|
|type B pancreatic cell development|
|excitatory synapse assembly|
|tripartite regional subdivision|
|anterior/posterior axis specification, embryo|
|regulation of chemokine biosynthetic process|
|cell migration involved in gastrulation|
|positive regulation of interleukin-8 secretion|
|regulation of establishment of planar polarity involved in neural tube closure|
|regulation of protein kinase C signaling|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|regulation of cytokine secretion involved in immune response|
|negative regulation of morphogenesis of an epithelium|
|establishment of epithelial cell apical/basal polarity|
|positive regulation of T cell chemotaxis|
|branch elongation of an epithelium|
|female genitalia development|
|regulation of T cell chemotaxis|
|regulation of cell-cell adhesion mediated by cadherin|
|paraxial mesoderm development|
|positive regulation of lymphocyte apoptotic process|
|glandular epithelial cell development|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|regulation of epithelial tube formation|
|type B pancreatic cell differentiation|
|polarized epithelial cell differentiation|
|postsynapse assembly|
|presynapse assembly|
|blastoderm segmentation|
|post-anal tail morphogenesis|
|pericardium development|
|notochord development|
|regulation of hair follicle development|
|enteroendocrine cell differentiation|
|positive regulation of tumor necrosis factor secretion|
|establishment of apical/basal cell polarity|
|positive regulation of lymphocyte chemotaxis|
|establishment of monopolar cell polarity|
|uterus development|
|presynapse organization|
|negative regulation of neural precursor cell proliferation|
|establishment of tissue polarity|
|establishment of planar polarity|
|branching involved in mammary gland duct morphogenesis|
|establishment or maintenance of monopolar cell polarity|
|regulation of non-canonical Wnt signaling pathway|
|cochlea morphogenesis|
|secondary palate development|
|cell surface receptor signaling pathway involved in heart development|
|regulation of interleukin-8 secretion|
|positive regulation of meiotic cell cycle|
|negative regulation of synapse organization|
|positive regulation of macrophage activation|
|positive regulation of mesenchymal cell proliferation|
|regulation of protein localization to synapse|
|negative regulation of axon extension involved in axon guidance|
|embryonic camera-type eye morphogenesis|
|negative regulation of embryonic development|
|regulation of lymphocyte chemotaxis|
|axis elongation|
|positive regulation of G protein-coupled receptor signaling pathway|
|positive regulation of leukocyte apoptotic process|
|gastrulation with mouth forming second|
|negative regulation of axon guidance|
|regulation of hair cycle|
|positive regulation of peptidyl-threonine phosphorylation|
|regulation of tumor necrosis factor secretion|
|regulation of fibroblast growth factor receptor signaling pathway|
|cardiac atrium morphogenesis|
|dopaminergic neuron differentiation|
|establishment of epithelial cell polarity|
|mammary gland duct morphogenesis|
|positive regulation of T cell migration|
|forebrain neuron development|
|regulation of meiotic nuclear division|
|regulation of axon extension involved in axon guidance|
|activation of protein kinase B activity|
|olfactory bulb development|
|regulation of T cell apoptotic process|
|receptor ligand activity|
|brain morphogenesis|
|clathrin-coated endocytic vesicle membrane|
|positive regulation of interleukin-1 beta secretion|
|olfactory lobe development|
|regulation of mesenchymal cell proliferation|
|positive regulation of cartilage development|
|negative regulation of animal organ morphogenesis|
|embryonic eye morphogenesis|
|regulation of type I interferon-mediated signaling pathway|
|cardiac atrium development|
|embryonic axis specification|
|regulation of animal organ formation|
|positive regulation of lymphocyte migration|
|embryonic camera-type eye development|
|Wnt signaling pathway, calcium modulating pathway|
|endocrine pancreas development|
|positive regulation of interleukin-1 secretion|
|glandular epithelial cell differentiation|
|positive regulation of epidermis development|
|activation of JUN kinase activity|
|frizzled binding|
|ventricular septum morphogenesis|
|pituitary gland development|
|negative regulation of axon extension|
|mammary gland morphogenesis|
|morphogenesis of a polarized epithelium|
|regulation of peptidyl-threonine phosphorylation|
|regulation of T cell migration|
|regulation of axon guidance|
|negative chemotaxis|
|establishment or maintenance of epithelial cell apical/basal polarity|
|negative regulation of fat cell differentiation|
|regulation of interleukin-1 beta secretion|
|genitalia development|
|digestive tract morphogenesis|
|face development|
|positive chemotaxis|
|establishment or maintenance of apical/basal cell polarity|
|morphogenesis of an epithelial sheet|
|positive regulation of interleukin-8 production|
|columnar/cuboidal epithelial cell development|
|negative regulation of BMP signaling pathway|
|regulation of meiotic cell cycle|
|establishment or maintenance of bipolar cell polarity|
|mesenchyme morphogenesis|
|positive regulation of cytokine-mediated signaling pathway|
|anterior/posterior axis specification|
|positive regulation of fibroblast proliferation|
|forebrain neuron differentiation|
|positive regulation of interleukin-1 beta production|
|cochlea development|
|regulation of lymphocyte apoptotic process|
|regulation of macrophage activation|
|clathrin-coated vesicle membrane|
|stem cell proliferation|
|regulation of interleukin-1 secretion|
|positive regulation of cytokine production involved in immune response|
|positive regulation of chemokine production|
|regulation of morphogenesis of a branching structure|
|negative regulation of reproductive process|
|positive regulation of response to cytokine stimulus|
|negative regulation of chemotaxis|
|mammary gland epithelium development|
|positive regulation of interleukin-1 production|
|heart looping|
|embryonic digit morphogenesis|
|regulation of lymphocyte migration|
|embryonic pattern specification|
|positive regulation of interferon-gamma production|
|somitogenesis|
|forebrain generation of neurons|
|embryonic heart tube morphogenesis|
|determination of heart left/right asymmetry|
|positive regulation of nuclear division|
|mesoderm formation|
|positive regulation of cytokine biosynthetic process|
|endocytic vesicle membrane|
|cardiac muscle tissue morphogenesis|
|regulation of interleukin-8 production|
|mesoderm morphogenesis|
|cellular response to retinoic acid|
|negative regulation of axonogenesis|
|regulation of cartilage development|
|epithelial to mesenchymal transition|
|pancreas development|
|positive regulation of JUN kinase activity|
|ventricular septum development|
|outflow tract morphogenesis|
|cardiac septum morphogenesis|
|diencephalon development|
|embryonic heart tube development|
|lens development in camera-type eye|
|regulation of chemokine production|
|positive regulation of reproductive process|
|central nervous system neuron development|
|muscle tissue morphogenesis|
|JNK cascade|
|regulation of fibroblast proliferation|
|regulation of interleukin-1 beta production|
|regulation of leukocyte apoptotic process|
|somite development|
|postsynapse|
|cellular response to calcium ion|
|regulation of cytokine production involved in immune response|
|positive regulation of ossification|
|positive regulation of tumor necrosis factor production|
|regulation of epidermis development|
|midbrain development|
|axis specification|
|muscle organ morphogenesis|
|epithelial cell proliferation|
|regulation of JUN kinase activity|
|regulation of BMP signaling pathway|
|regulation of neural precursor cell proliferation|
|postsynapse organization|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|roof of mouth development|
|canonical Wnt signaling pathway|
|neural tube closure|
|positive regulation of neuron death|
|tube closure|
|positive regulation of protein binding|
|synapse assembly|
|positive regulation of endothelial cell proliferation|
|positive regulation of interleukin-6 production|
|regulation of interleukin-1 production|
|segmentation|
|columnar/cuboidal epithelial cell differentiation|
|positive regulation of production of molecular mediator of immune response|
|regulation of axon extension|
|regulation of postsynapse organization|
|Wnt signaling pathway, planar cell polarity pathway|
|negative regulation of cell morphogenesis involved in differentiation|
|primary neural tube formation|
|activation of GTPase activity|
|inner ear morphogenesis|
|positive regulation of endothelial cell migration|
|gland morphogenesis|
|regulation of interferon-gamma production|
|positive regulation of endocytosis|
|Golgi lumen|
|positive regulation of peptidyl-serine phosphorylation|
|phospholipid binding|
|regulation of cytokine biosynthetic process|
|negative regulation of developmental growth|
|regulation of synapse assembly|
|stress-activated MAPK cascade|
|neural tube formation|
|female sex differentiation|
|response to retinoic acid|
|cardiac septum development|
|regulation of extent of cell growth|
|formation of primary germ layer|
|regulation of establishment of planar polarity|
|regulation of leukocyte chemotaxis|
|camera-type eye morphogenesis|
|developmental growth involved in morphogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|determination of left/right symmetry|
|establishment of cell polarity|
|ear morphogenesis|
|endocrine system development|
|regulation of fat cell differentiation|
|determination of bilateral symmetry|
|embryonic epithelial tube formation|
|mesoderm development|
|specification of symmetry|
|negative regulation of epithelial cell proliferation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|cardiac chamber morphogenesis|
|embryonic skeletal system development|
|mammary gland development|
|cardiac ventricle development|
|positive regulation of leukocyte migration|
|regulation of endothelial cell proliferation|
|regulation of embryonic development|
|digestive tract development|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|male gonad development|
|non-canonical Wnt signaling pathway|
|development of primary male sexual characteristics|
|positive regulation of chemotaxis|
|regulation of peptidyl-serine phosphorylation|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|positive regulation of JNK cascade|
|regulation of interleukin-6 production|
|regulation of production of molecular mediator of immune response|
|positive regulation of epithelial cell migration|
|stress-activated protein kinase signaling cascade|
|regulation of G protein-coupled receptor signaling pathway|
|digestive system development|
|morphogenesis of embryonic epithelium|
|negative regulation of cellular response to growth factor stimulus|
|tube formation|
|eye morphogenesis|
|regulation of tumor necrosis factor production|
|appendage morphogenesis|
|limb morphogenesis|
|response to calcium ion|
|regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of NF-kappaB transcription factor activity|
|negative regulation of neuron projection development|
|cellular response to transforming growth factor beta stimulus|
|activation of MAPK activity|
|male sex differentiation|
|mesenchymal cell differentiation|
|regulation of endothelial cell migration|
|morphogenesis of a branching epithelium|
|gastrulation|
|neural tube development|
|regulation of reproductive process|
|cardiac muscle tissue development|
|response to transforming growth factor beta|
|cellular response to interferon-gamma|
|positive regulation of angiogenesis|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|morphogenesis of a branching structure|
|positive regulation of stress-activated protein kinase signaling cascade|
|lung development|
|cardiac chamber development|
|ameboidal-type cell migration|
|cartilage development|
|respiratory tube development|
|cytokine activity|
|negative regulation of canonical Wnt signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of Wnt signaling pathway|
|positive regulation of binding|
|central nervous system neuron differentiation|
|regulation of morphogenesis of an epithelium|
|appendage development|
|limb development|
|negative regulation of cell projection organization|
|response to interferon-gamma|
|regulation of cell size|
|negative regulation of cell growth|
|positive regulation of vasculature development|
|cellular response to lipopolysaccharide|
|regulation of axonogenesis|
|regulation of JNK cascade|
|positive regulation of epithelial cell proliferation|
|regulation of ossification|
|epithelial cell development|
|regulation of nuclear division|
|cellular response to metal ion|
|cellular response to molecule of bacterial origin|
|inner ear development|
|respiratory system development|
|regulation of leukocyte migration|
|establishment or maintenance of cell polarity|
|regulation of cytokine secretion|
|regulation of endocytosis|
|cellular response to acid chemical|
|gonad development|
|negative regulation of Wnt signaling pathway|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|development of primary sexual characteristics|
|anterior/posterior pattern specification|
|positive regulation of protein catabolic process|
|transcription regulatory region DNA binding|
|regulation of synapse organization|
|positive regulation of immune effector process|
|regulation of protein binding|
|cellular response to inorganic substance|
|regulation of epithelial cell migration|
|mesenchyme development|
|ear development|
|connective tissue development|
|negative regulation of neuron differentiation|
|regulation of synapse structure or activity|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of growth|
|protein domain specific binding|
|cell fate commitment|
|heart morphogenesis|
|positive regulation of cell-cell adhesion|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|telencephalon development|
|axon guidance|
|positive regulation of MAP kinase activity|
|neuron projection guidance|
|positive regulation of DNA-binding transcription factor activity|
|sex differentiation|
|positive regulation of protein secretion|
|synapse organization|
|regulation of cellular response to growth factor stimulus|
|keratinocyte differentiation|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|renal system development|
|striated muscle tissue development|
|positive regulation of cell cycle process|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|muscle organ development|
|muscle tissue development|
|endoplasmic reticulum lumen|
|regulation of cell morphogenesis involved in differentiation|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|regulation of neuron death|
|negative regulation of nervous system development|
|camera-type eye development|
|response to lipopolysaccharide|
|epidermal cell differentiation|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to molecule of bacterial origin|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|regulation of developmental growth|
|regionalization|
|regulation of epithelial cell proliferation|
|negative regulation of cell development|
|regulation of inflammatory response|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|response to acid chemical|
|glutamatergic synapse|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|eye development|
|visual system development|
|regulation of Wnt signaling pathway|
|positive regulation of response to biotic stimulus|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|sensory system development|
|response to metal ion|
|MAPK cascade|
|axonogenesis|
|positive regulation of cell cycle|
|regulation of binding|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|skin development|
|regulation of protein catabolic process|
|forebrain development|
|developmental growth|
|growth|
|signal transduction by protein phosphorylation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|axon development|
|gland development|
|positive regulation of GTPase activity|
|epidermis development|
|positive regulation of cell activation|
|regulation of cell growth|
|reproductive structure development|
|positive regulation of protein transport|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|regulation of DNA-binding transcription factor activity|
|reproductive system development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of catabolic process|
|embryonic organ development|
|positive regulation of secretion|
|pattern specification process|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|muscle structure development|
|wound healing|
|neuron projection morphogenesis|
|regulation of GTPase activity|
|plasma membrane bounded cell projection morphogenesis|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|skeletal system development|
|regulation of peptide secretion|
|regulation of neuron projection development|
|cellular response to growth factor stimulus|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|cell part morphogenesis|
|regulation of anatomical structure size|
|regulation of protein serine/threonine kinase activity|
|cellular response to lipid|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|heart development|
|response to growth factor|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|sensory organ development|
|chemotaxis|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|chordate embryonic development|
|regulation of cell activation|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|immune system development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|positive regulation of transferase activity|
|neuron projection development|
|developmental process involved in reproduction|
|regulation of growth|
|DNA-binding transcription factor activity|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|response to bacterium|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of protein transport|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cell morphogenesis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|brain development|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|positive regulation of hydrolase activity|
|regulation of multi-organism process|
|head development|
|ion homeostasis|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|membrane organization|
|response to lipid|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of catabolic process|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
\\
=== CRISPR Data ===
^Screen^Score^
|[[:results:exp148|SB202190 10μM R03 exp148]]|2.11|
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 4579
* **Expression level (log2 read counts)**: -1.89
{{:chemogenomics:nalm6 dist.png?nolink |}}