======= WNT8A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: WNT8A
  * **<color #00a2e8>Official Name</color>**: Wnt family member 8A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7478|7478]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H1J5|Q9H1J5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WNT8A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WNT8A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning. {ECO:0000250|UniProtKB:P51028}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|wnt|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|canonical Wnt signaling pathway involved in neural crest cell differentiation|
|canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment|
|regulation of transcription involved in anterior/posterior axis specification|
|canonical Wnt signaling pathway involved in heart development|
|neural crest cell fate commitment|
|Wnt signaling pathway involved in heart development|
|cardiac muscle cell fate commitment|
|stem cell fate commitment|
|cardiac cell fate commitment|
|neural crest formation|
|muscle cell fate commitment|
|beta-catenin destruction complex disassembly|
|secondary palate development|
|cell surface receptor signaling pathway involved in heart development|
|receptor ligand activity|
|frizzled binding|
|anterior/posterior axis specification|
|epithelial to mesenchymal transition|
|axis specification|
|cardiac muscle cell differentiation|
|neural crest cell differentiation|
|canonical Wnt signaling pathway|
|roof of mouth development|
|response to retinoic acid|
|cardiocyte differentiation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cardiac muscle tissue development|
|striated muscle cell differentiation|
|anterior/posterior pattern specification|
|mesenchyme development|
|protein-containing complex disassembly|
|muscle cell differentiation|
|cell fate commitment|
|striated muscle tissue development|
|muscle tissue development|
|regionalization|
|response to acid chemical|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|collagen-containing extracellular matrix|
|cellular component disassembly|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|pattern specification process|
|muscle structure development|
|heart development|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|response to lipid|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|neuron differentiation|
|cell-cell signaling|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|neurogenesis|
|tissue development|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9426
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WNT8A Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>