======= WRB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GET1
  * **<color #00a2e8>Official Name</color>**: guided entry of tail-anchored proteins factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7485|7485]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00258|O00258]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=WRB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20WRB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602915|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane. {ECO:0000269|PubMed:21444755}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CHD5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tail-anchored membrane protein insertion into ER membrane|
|protein insertion into ER membrane|
|protein insertion into membrane|
|endoplasmic reticulum organization|
|establishment of protein localization to membrane|
|endomembrane system organization|
|protein localization to membrane|
|protein localization to organelle|
|membrane organization|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-2.6|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-2.28|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.9|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.89|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.88|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.84|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.8|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-1.76|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.74|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.72|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.81|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:get4|GET4]]|0.621|
|[[:human genes:p:ptar1|PTAR1]]|0.579|
|[[:human genes:p:pmvk|PMVK]]|0.515|
|[[:human genes:p:ppp6c|PPP6C]]|0.464|
|[[:human genes:c:cog2|COG2]]|0.44|
|[[:human genes:g:gemin6|GEMIN6]]|0.434|
|[[:human genes:u:urm1|URM1]]|0.431|
|[[:human genes:p:pgm3|PGM3]]|0.421|
|[[:human genes:s:scap|SCAP]]|0.42|
|[[:human genes:g:gemin8|GEMIN8]]|0.409|
|[[:human genes:z:zcrb1|ZCRB1]]|0.403|
|[[:human genes:c:camlg|CAMLG]]|0.402|
|[[:human genes:t:ten1|TEN1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 104/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|7/28|
|blood|2/28|
|bone|3/26|
|breast|5/33|
|central nervous system|10/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|8/21|
|liver|5/20|
|lung|13/75|
|lymphocyte|2/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 948
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='WRB Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>