======= XAB2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XAB2
  * **<color #00a2e8>Official Name</color>**: XPA binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56949|56949]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HCS7|Q9HCS7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XAB2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XAB2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610850|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|generation of catalytic spliceosome for first transesterification step|
|spliceosomal conformational changes to generate catalytic conformation|
|post-mRNA release spliceosomal complex|
|Prp19 complex|
|U2-type catalytic step 2 spliceosome|
|transcription-coupled nucleotide-excision repair|
|catalytic step 2 spliceosome|
|blastocyst development|
|nucleotide-excision repair|
|cerebral cortex development|
|pallium development|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|telencephalon development|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|in utero embryonic development|
|forebrain development|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|DNA repair|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|mRNA metabolic process|
|brain development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|head development|
|cellular protein-containing complex assembly|
|RNA processing|
|embryo development|
|central nervous system development|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-3.2|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.74|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.7|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.55|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-2.47|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.29|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.28|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.27|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.01|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.96|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.94|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|-1.87|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.79|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.77|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.77|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.76|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.76|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.76|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.74|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.73|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.72|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.73|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.74|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.76|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.76|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.76|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.82|
|[[:results:exp303|39°C R06 exp303]]|1.84|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.85|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.85|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.92|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.93|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.97|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|2|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2|
|[[:results:exp219|A-395N 10μM R05 exp219]]|2.34|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|2.38|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.43|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|2.69|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|2.77|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|3.08|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|3.13|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|3.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.575|
|[[:human genes:u:upf1|UPF1]]|0.529|
|[[:human genes:e:exosc5|EXOSC5]]|0.494|
|[[:human genes:p:psmb4|PSMB4]]|0.491|
|[[:human genes:r:rps12|RPS12]]|0.488|
|[[:human genes:p:pola1|POLA1]]|0.488|
|[[:human genes:p:polr2j3|POLR2J3]]|0.484|
|[[:human genes:c:cbwd3|CBWD3]]|0.482|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.479|
|[[:human genes:d:ddtl|DDTL]]|0.471|
|[[:human genes:p:psmb2|PSMB2]]|0.469|
|[[:human genes:s:supt5h|SUPT5H]]|0.464|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.463|
|[[:human genes:k:krt2|KRT2]]|0.462|
|[[:human genes:c:copg1|COPG1]]|0.46|
|[[:human genes:f:fam25b|FAM25B]]|0.459|
|[[:human genes:c:cbwd5|CBWD5]]|0.456|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.455|
|[[:human genes:p:psmc5|PSMC5]]|0.45|
|[[:human genes:c:cbwd6|CBWD6]]|0.447|
|[[:human genes:c:copa|COPA]]|0.446|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.446|
|[[:human genes:t:tfip11|TFIP11]]|0.444|
|[[:human genes:p:psma6|PSMA6]]|0.442|
|[[:human genes:p:psmd3|PSMD3]]|0.44|
|[[:human genes:t:tceb3c|TCEB3C]]|0.439|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.438|
|[[:human genes:r:rrp7a|RRP7A]]|0.438|
|[[:human genes:k:krt78|KRT78]]|0.438|
|[[:human genes:p:psma7|PSMA7]]|0.437|
|[[:human genes:o:orc1|ORC1]]|0.437|
|[[:human genes:e:exosc9|EXOSC9]]|0.435|
|[[:human genes:a:aqr|AQR]]|0.431|
|[[:human genes:c:cdc45|CDC45]]|0.43|
|[[:human genes:s:smg1|SMG1]]|0.43|
|[[:human genes:z:znf830|ZNF830]]|0.428|
|[[:human genes:n:nupl1|NUPL1]]|0.428|
|[[:human genes:t:tyms|TYMS]]|0.428|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.426|
|[[:human genes:c:chaf1a|CHAF1A]]|0.426|
|[[:human genes:r:ranbp2|RANBP2]]|0.425|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.425|
|[[:human genes:h:hivep3|HIVEP3]]|0.425|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.425|
|[[:human genes:i:ints5|INTS5]]|0.424|
|[[:human genes:p:psmc2|PSMC2]]|0.423|
|[[:human genes:r:rbbp5|RBBP5]]|0.422|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.422|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.421|
|[[:human genes:c:cdh24|CDH24]]|0.42|
|[[:human genes:t:traip|TRAIP]]|0.42|
|[[:human genes:c:ccna2|CCNA2]]|0.419|
|[[:human genes:r:rpl35|RPL35]]|0.418|
|[[:human genes:s:sf3a1|SF3A1]]|0.417|
|[[:human genes:a:ankle1|ANKLE1]]|0.417|
|[[:human genes:w:wdr75|WDR75]]|0.417|
|[[:human genes:s:snrpa1|SNRPA1]]|0.415|
|[[:human genes:t:tonsl|TONSL]]|0.415|
|[[:human genes:i:iscu|ISCU]]|0.414|
|[[:human genes:c:c14orf93|C14orf93]]|0.412|
|[[:human genes:p:pole|POLE]]|0.411|
|[[:human genes:s:syt9|SYT9]]|0.411|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.411|
|[[:human genes:p:plk1|PLK1]]|0.411|
|[[:human genes:c:ccdc116|CCDC116]]|0.41|
|[[:human genes:c:cope|COPE]]|0.41|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.409|
|[[:human genes:n:nsf|NSF]]|0.409|
|[[:human genes:c:chd4|CHD4]]|0.407|
|[[:human genes:p:psmd14|PSMD14]]|0.406|
|[[:human genes:n:nup160|NUP160]]|0.406|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.405|
|[[:human genes:a:aatf|AATF]]|0.405|
|[[:human genes:o:ogfr|OGFR]]|0.404|
|[[:human genes:b:bysl|BYSL]]|0.404|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.404|
|[[:human genes:t:tspy2|TSPY2]]|0.404|
|[[:human genes:t:tpx2|TPX2]]|0.404|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.404|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.404|
|[[:human genes:c:cactin|CACTIN]]|0.404|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.404|
|[[:human genes:r:rps5|RPS5]]|0.403|
|[[:human genes:g:golga8o|GOLGA8O]]|0.403|
|[[:human genes:t:trappc11|TRAPPC11]]|0.402|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.402|
|[[:human genes:p:prss8|PRSS8]]|0.4|
|[[:human genes:m:med17|MED17]]|0.4|
|[[:human genes:l:lrr1|LRR1]]|0.4|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.4|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 739/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 444
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XAB2 Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>