======= XPC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPC
  * **<color #00a2e8>Official Name</color>**: XPC complex subunit, DNA damage recognition and repair factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7508|7508]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q01831|Q01831]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613208|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad4|
|BHD 1|
|BHD 2|
|BHD 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleotide-excision repair factor 2 complex|
|heteroduplex DNA loop binding|
|UV-damage excision repair, DNA incision|
|XPC complex|
|pyrimidine dimer repair by nucleotide-excision repair|
|nucleotide-excision repair complex|
|bubble DNA binding|
|pyrimidine dimer repair|
|UV-damage excision repair|
|intra-S DNA damage checkpoint|
|response to UV-B|
|site of DNA damage|
|nucleotide-excision repair, DNA duplex unwinding|
|nucleotide-excision repair, DNA damage recognition|
|global genome nucleotide-excision repair|
|response to auditory stimulus|
|nucleotide-excision repair, preincision complex assembly|
|mismatch repair|
|damaged DNA binding|
|cellular response to UV|
|mitotic DNA damage checkpoint|
|mitotic DNA integrity checkpoint|
|single-stranded DNA binding|
|DNA duplex unwinding|
|nucleotide-excision repair|
|cellular response to light stimulus|
|DNA geometric change|
|DNA damage checkpoint|
|response to UV|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|cellular response to radiation|
|cell cycle checkpoint|
|protein-DNA complex assembly|
|response to mechanical stimulus|
|protein-DNA complex subunit organization|
|protein-containing complex binding|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|negative regulation of mitotic cell cycle|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of mitotic cell cycle phase transition|
|response to radiation|
|regulation of cell cycle phase transition|
|DNA repair|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|DNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|cellular protein-containing complex assembly|
|nucleolus|
|cell cycle process|
|response to drug|
|chromosome organization|
|response to abiotic stimulus|
|regulation of cell cycle|
|mitochondrion|
|cell cycle|
|protein-containing complex assembly|
|cellular response to stress|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14694
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPC Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>