======= XPOT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPOT
  * **<color #00a2e8>Official Name</color>**: exportin for tRNA
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11260|11260]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43592|O43592]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPOT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPOT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603180|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:12138183, ECO:0000269|PubMed:9512417, ECO:0000269|PubMed:9660920}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Xpo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA re-export from nucleus|
|tRNA export from nucleus|
|tRNA-containing ribonucleoprotein complex export from nucleus|
|tRNA transport|
|Ran GTPase binding|
|ncRNA export from nucleus|
|tRNA binding|
|nuclear pore|
|nuclear matrix|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|protein export from nucleus|
|nuclear export|
|RNA transport|
|nucleic acid transport|
|establishment of RNA localization|
|RNA localization|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.66|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|-2.65|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.6|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-2.58|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.41|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.32|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.28|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.28|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.24|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.21|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.14|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.09|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.07|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.04|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.03|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.95|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.95|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.89|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.88|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.85|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.84|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.83|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.8|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-1.79|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.77|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.76|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.75|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.74|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|-1.74|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.74|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.73|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-1.7|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.75|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.75|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.85|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.88|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|1.98|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fli1|FLI1]]|0.488|
|[[:human genes:x:xpo6|XPO6]]|0.48|
|[[:human genes:t:tti2|TTI2]]|0.461|
|[[:human genes:r:rnmt|RNMT]]|0.451|
|[[:human genes:h:hars|HARS]]|0.45|
|[[:human genes:o:otud5|OTUD5]]|0.447|
|[[:human genes:p:pdap1|PDAP1]]|0.443|
|[[:human genes:u:ubr5|UBR5]]|0.437|
|[[:human genes:s:shoc2|SHOC2]]|0.437|
|[[:human genes:m:mapk14|MAPK14]]|0.437|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.432|
|[[:human genes:m:med23|MED23]]|0.429|
|[[:human genes:t:trmt5|TRMT5]]|0.426|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.421|
|[[:human genes:k:kcmf1|KCMF1]]|0.416|
|[[:human genes:d:dnajc3|DNAJC3]]|0.416|
|[[:human genes:p:polr3h|POLR3H]]|0.412|
|[[:human genes:p:ppp4c|PPP4C]]|0.406|
|[[:human genes:a:atf7ip|ATF7IP]]|0.406|
|[[:human genes:u:ube2l3|UBE2L3]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5157
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPOT Expression in NALM6 Cells: 7.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>