======= XPR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XPR1
  * **<color #00a2e8>Official Name</color>**: xenotropic and polytropic retrovirus receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9213|9213]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBH6|Q9UBH6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XPR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XPR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605237|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in phosphate homeostasis. Mediates phosphate export from the cell (PubMed:23791524, PubMed:25938945). Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5- InsP7); these are important intracellular signaling molecules (PubMed:27080106). {ECO:0000250|UniProtKB:Q9Z0U0, ECO:0000269|PubMed:23791524, ECO:0000269|PubMed:25938945, ECO:0000269|PubMed:27080106}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EXS|
|SPX|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to phosphate starvation|
|phosphate ion transmembrane transporter activity|
|inositol hexakisphosphate binding|
|efflux transmembrane transporter activity|
|cellular divalent inorganic anion homeostasis|
|cellular trivalent inorganic anion homeostasis|
|cellular phosphate ion homeostasis|
|phosphate ion homeostasis|
|divalent inorganic anion homeostasis|
|trivalent inorganic anion homeostasis|
|cellular monovalent inorganic anion homeostasis|
|cellular anion homeostasis|
|phosphate ion transmembrane transport|
|phosphate ion transport|
|monovalent inorganic anion homeostasis|
|intrinsic component of plasma membrane|
|anion homeostasis|
|virus receptor activity|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|inorganic anion transmembrane transport|
|transmembrane signaling receptor activity|
|cellular response to starvation|
|interaction with host|
|inorganic anion transport|
|response to starvation|
|viral life cycle|
|signaling receptor activity|
|cellular response to nutrient levels|
|cellular response to extracellular stimulus|
|anion transmembrane transport|
|response to virus|
|cellular response to external stimulus|
|response to nutrient levels|
|response to extracellular stimulus|
|anion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|viral process|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|symbiotic process|
|ion homeostasis|
|interspecies interaction between organisms|
|cellular homeostasis|
|ion transmembrane transport|
|Golgi apparatus|
|chemical homeostasis|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|ion transport|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-3.18|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.95|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.51|
|[[:results:exp275|Citral 75μM R06 exp275]]|-2.47|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.4|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.4|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.32|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.31|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.28|
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.23|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.23|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.19|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-2.11|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-2.05|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.01|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.99|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.99|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-1.96|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.94|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.94|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.9|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.88|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.84|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.82|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-1.81|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.8|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.8|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.79|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.78|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.76|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.73|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.94|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.27|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.27|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.68|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.11|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|3.85|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|4.3|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|8.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kidins220|KIDINS220]]|0.73|
|[[:human genes:i:ip6k2|IP6K2]]|0.663|
|[[:human genes:i:ip6k1|IP6K1]]|0.58|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 10/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XPR1 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>