======= XRCC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XRCC1
  * **<color #00a2e8>Official Name</color>**: X-ray repair cross complementing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7515|7515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18887|P18887]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XRCC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XRCC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/194360|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity. {ECO:0000269|PubMed:28002403}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PTCB-BRCT|
|BRCT|
|XRCC1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of DNA ligase activity|
|oxidized DNA binding|
|regulation of DNA ligase activity|
|positive regulation of single strand break repair|
|negative regulation of protein ADP-ribosylation|
|3 overhang single-stranded DNA endodeoxyribonuclease activity|
|telomeric DNA-containing double minutes formation|
|negative regulation of protection from non-homologous end joining at telomere|
|regulation of protection from non-homologous end joining at telomere|
|base-excision repair, DNA ligation|
|regulation of single strand break repair|
|replication-born double-strand break repair via sister chromatid exchange|
|negative regulation of telomere maintenance in response to DNA damage|
|regulation of telomere maintenance in response to DNA damage|
|ERCC4-ERCC1 complex|
|positive regulation of DNA ligation|
|regulation of DNA ligation|
|positive regulation of ligase activity|
|single strand break repair|
|voluntary musculoskeletal movement|
|negative regulation of telomere capping|
|DNA ligation involved in DNA repair|
|regulation of ligase activity|
|regulation of protein ADP-ribosylation|
|telomere maintenance via recombination|
|DNA ligation|
|mitotic recombination|
|response to hydroperoxide|
|nucleotide-excision repair, DNA gap filling|
|regulation of telomere capping|
|negative regulation of telomere maintenance|
|cerebellum morphogenesis|
|base-excision repair|
|hindbrain morphogenesis|
|multicellular organismal movement|
|musculoskeletal movement|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|positive regulation of DNA repair|
|transcription-coupled nucleotide-excision repair|
|negative regulation of response to DNA damage stimulus|
|hippocampus development|
|regulation of telomere maintenance|
|double-strand break repair via homologous recombination|
|telomere maintenance|
|positive regulation of response to DNA damage stimulus|
|recombinational repair|
|telomere organization|
|cerebellum development|
|limbic system development|
|nuclear chromosome, telomeric region|
|nucleotide-excision repair|
|metencephalon development|
|negative regulation of DNA metabolic process|
|regulation of DNA repair|
|negative regulation of chromosome organization|
|hindbrain development|
|pallium development|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|regulation of response to DNA damage stimulus|
|DNA recombination|
|nuclear chromatin|
|telencephalon development|
|anatomical structure homeostasis|
|response to hypoxia|
|enzyme binding|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|response to decreased oxygen levels|
|negative regulation of organelle organization|
|response to oxygen levels|
|response to oxidative stress|
|forebrain development|
|DNA repair|
|negative regulation of protein modification process|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|brain development|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|head development|
|nucleolus|
|central nervous system development|
|response to drug|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|homeostatic process|
|cellular response to stress|
|positive regulation of molecular function|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.64|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.94|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-1.89|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.82|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chtf8|CHTF8]]|0.454|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|1/26|
|breast|2/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1804
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XRCC1 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>