======= XRN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: XRN2
  * **<color #00a2e8>Official Name</color>**: 5'-3' exoribonuclease 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22803|22803]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0D6|Q9H0D6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=XRN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20XRN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608851|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224). {ECO:0000250, ECO:0000269|PubMed:15565158, ECO:0000269|PubMed:16648491, ECO:0000269|PubMed:21700224}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|XRN N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription termination site sequence-specific DNA binding|
|5-3 exoribonuclease activity|
|DNA catabolic process, exonucleolytic|
|5-3 exonuclease activity|
|nuclease activity|
|DNA catabolic process|
|3-5-exoribonuclease activity|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|aggresome|
|DNA-templated transcription, termination|
|hippocampus development|
|limbic system development|
|retina development in camera-type eye|
|RNA phosphodiester bond hydrolysis|
|pallium development|
|rRNA processing|
|rRNA metabolic process|
|RNA catabolic process|
|telencephalon development|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|camera-type eye development|
|eye development|
|visual system development|
|sensory system development|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|forebrain development|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|gamete generation|
|mRNA metabolic process|
|brain development|
|DNA metabolic process|
|head development|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|central nervous system development|
|multi-organism reproductive process|
|neuron differentiation|
|macromolecule catabolic process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|generation of neurons|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.39|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.03|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.73|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|1.77|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.83|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|1.96|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.07|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.09|
|[[:results:exp453|B02 10μM R08 exp453]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.425|
|[[:human genes:k:kptn|KPTN]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 697/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|27/28|
|bone|25/26|
|breast|28/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|19/21|
|liver|18/20|
|lung|72/75|
|lymphocyte|15/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|25/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 931
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='XRN2 Expression in NALM6 Cells: 7.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>