======= YES1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YES1
  * **<color #00a2e8>Official Name</color>**: YES proto-oncogene 1, Src family tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7525|7525]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07947|P07947]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YES1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YES1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164880|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH2|
|Pkinase Tyr|
|SH3 1|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|postsynaptic specialization, intracellular component|
|cellular response to platelet-derived growth factor stimulus|
|response to platelet-derived growth factor|
|peptidyl-tyrosine autophosphorylation|
|epidermal growth factor receptor binding|
|regulation of vascular permeability|
|phosphotyrosine residue binding|
|non-membrane spanning protein tyrosine kinase activity|
|T cell costimulation|
|lymphocyte costimulation|
|extrinsic component of cytoplasmic side of plasma membrane|
|cellular response to retinoic acid|
|regulation of glucose transmembrane transport|
|actin filament|
|ephrin receptor signaling pathway|
|protein tyrosine kinase activity|
|response to retinoic acid|
|ion channel binding|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|Fc-gamma receptor signaling pathway|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|cellular response to transforming growth factor beta stimulus|
|microtubule organizing center|
|response to transforming growth factor beta|
|vascular process in circulatory system|
|positive regulation of peptidyl-tyrosine phosphorylation|
|protein autophosphorylation|
|positive regulation of T cell activation|
|cellular response to acid chemical|
|positive regulation of leukocyte cell-cell adhesion|
|Fc receptor signaling pathway|
|regulation of peptidyl-tyrosine phosphorylation|
|positive regulation of cell-cell adhesion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|phagocytosis|
|signaling receptor binding|
|response to acid chemical|
|glutamatergic synapse|
|enzyme binding|
|positive regulation of lymphocyte activation|
|leukocyte migration|
|blood circulation|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|focal adhesion|
|positive regulation of cell activation|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|cellular response to lipid|
|response to growth factor|
|immune response-activating signal transduction|
|regulation of transmembrane transport|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|activation of immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|response to lipid|
|positive regulation of immune response|
|peptidyl-amino acid modification|
|cell migration|
|protein phosphorylation|
|Golgi apparatus|
|positive regulation of protein phosphorylation|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|localization of cell|
|cell motility|
|immune effector process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|ATP binding|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.97|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.85|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.75|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.74|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.7|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|2.06|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.509|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18807
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YES1 Expression in NALM6 Cells: 4.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>