======= YTHDF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YTHDF2
  * **<color #00a2e8>Official Name</color>**: YTH N6-methyladenosine RNA binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51441|51441]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5A9|Q9Y5A9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YTHDF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YTHDF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610640|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non- coding RNAs and plays a role in mRNA stability and processing (PubMed:22575960, PubMed:24284625, PubMed:25412658, PubMed:25412661). Acts as a regulator of mRNA stability: binding to m6A-containing mRNAs results in the localization to mRNA decay sites, such as processing bodies (P-bodies), leading to mRNA degradation (PubMed:24284625, PubMed:26046440). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also involved in haematopoietic stem cells specification: acts by binding to m6A-containing mRNAs, leading to decrease Notch dignaling and promote endothelial to haematopoietic transition (By similarity). Also acts as a promoter of cap- independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation (PubMed:26458103). {ECO:0000250|UniProtKB:E7F1H9, ECO:0000250|UniProtKB:Q91YT7, ECO:0000269|PubMed:22575960, ECO:0000269|PubMed:24284625, ECO:0000269|PubMed:25412658, ECO:0000269|PubMed:25412661, ECO:0000269|PubMed:26046440, ECO:0000269|PubMed:26318451, ECO:0000269|PubMed:26458103}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|YTH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of meiotic cell cycle process involved in oocyte maturation|
|endothelial to hematopoietic transition|
|positive regulation of cap-independent translational initiation|
|regulation of cap-independent translational initiation|
|positive regulation of cytoplasmic translational initiation|
|regulation of cytoplasmic translational initiation|
|delamination|
|N6-methyladenosine-containing RNA binding|
|regulation of oocyte maturation|
|regulation of oogenesis|
|regulation of oocyte development|
|positive regulation of cytoplasmic translation|
|hematopoietic stem cell proliferation|
|negative regulation of type I interferon-mediated signaling pathway|
|oocyte maturation|
|regulation of cell maturation|
|regulation of cytoplasmic translation|
|mRNA destabilization|
|positive regulation of translational initiation|
|RNA destabilization|
|regulation of type I interferon-mediated signaling pathway|
|oocyte development|
|negative regulation of Notch signaling pathway|
|oocyte differentiation|
|positive regulation of mRNA catabolic process|
|regulation of meiotic cell cycle|
|stem cell proliferation|
|negative regulation of innate immune response|
|negative regulation of cytokine-mediated signaling pathway|
|negative regulation of response to cytokine stimulus|
|cytoplasmic ribonucleoprotein granule|
|regulation of hematopoietic stem cell differentiation|
|oogenesis|
|positive regulation of mRNA metabolic process|
|regulation of translational initiation|
|regulation of hematopoietic progenitor cell differentiation|
|P-body|
|negative regulation of response to biotic stimulus|
|regulation of Notch signaling pathway|
|regulation of stem cell differentiation|
|positive regulation of translation|
|female gamete generation|
|negative regulation of translation|
|anatomical structure maturation|
|negative regulation of cellular amide metabolic process|
|negative regulation of immune response|
|positive regulation of cellular amide metabolic process|
|cell maturation|
|microtubule organizing center|
|regulation of reproductive process|
|regulation of cytokine-mediated signaling pathway|
|negative regulation of cell-cell adhesion|
|regulation of response to cytokine stimulus|
|regulation of mRNA stability|
|regulation of RNA stability|
|regulation of mRNA catabolic process|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|mRNA catabolic process|
|developmental maturation|
|RNA catabolic process|
|germ cell development|
|negative regulation of cell adhesion|
|regulation of mRNA metabolic process|
|humoral immune response|
|regulation of translation|
|cellular process involved in reproduction in multicellular organism|
|positive regulation of cellular catabolic process|
|negative regulation of response to external stimulus|
|nucleobase-containing compound catabolic process|
|regulation of cell-cell adhesion|
|regulation of cellular amide metabolic process|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of hemopoiesis|
|regulation of innate immune response|
|organic cyclic compound catabolic process|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|cell population proliferation|
|hemopoiesis|
|cell morphogenesis involved in differentiation|
|embryonic morphogenesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|developmental process involved in reproduction|
|regulation of cell adhesion|
|gamete generation|
|mRNA metabolic process|
|cell morphogenesis|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|regulation of neurogenesis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|regulation of nervous system development|
|regulation of cell development|
|embryo development|
|regulation of catabolic process|
|multi-organism reproductive process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|regulation of immune response|
|regulation of cell cycle|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|reproductive process|
|reproduction|
|negative regulation of macromolecule biosynthetic process|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of immune system process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.56|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.41|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.34|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.16|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.12|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.08|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-2.07|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-2.06|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.99|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.95|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.92|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.89|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-1.88|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.87|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.85|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.84|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.78|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.76|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.76|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.72|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.71|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.72|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.77|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.81|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.89|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.07|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.12|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.14|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.16|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.54|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|4.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rbm26|RBM26]]|0.525|
|[[:human genes:c:cbll1|CBLL1]]|0.471|
|[[:human genes:m:mettl3|METTL3]]|0.439|
|[[:human genes:d:dph5|DPH5]]|0.416|
|[[:human genes:c:ctu2|CTU2]]|0.413|
|[[:human genes:m:mettl14|METTL14]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4461
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YTHDF2 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>