======= YWHAH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: YWHAH
  * **<color #00a2e8>Official Name</color>**: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7533|7533]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q04917|Q04917]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=YWHAH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20YWHAH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/113508|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1. {ECO:0000269|PubMed:12177059}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|14-3-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glucocorticoid catabolic process|
|glucocorticoid receptor signaling pathway|
|corticosteroid receptor signaling pathway|
|glucocorticoid metabolic process|
|negative regulation of dendrite morphogenesis|
|glucocorticoid receptor binding|
|hormone catabolic process|
|insulin-like growth factor receptor binding|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|steroid catabolic process|
|negative regulation of dendrite development|
|membrane depolarization during action potential|
|sodium channel regulator activity|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|substantia nigra development|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|intercalated disc|
|membrane depolarization|
|regulation of sodium ion transmembrane transporter activity|
|positive regulation of establishment of protein localization to mitochondrion|
|neural nucleus development|
|regulation of sodium ion transmembrane transport|
|intracellular steroid hormone receptor signaling pathway|
|regulation of mitochondrial membrane permeability|
|regulation of establishment of protein localization to mitochondrion|
|regulation of membrane permeability|
|midbrain development|
|regulation of sodium ion transport|
|regulation of dendrite morphogenesis|
|action potential|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of mitochondrion organization|
|steroid hormone mediated signaling pathway|
|positive regulation of protein localization to membrane|
|ion channel binding|
|mitochondrial membrane organization|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|negative regulation of cell projection organization|
|cellular response to steroid hormone stimulus|
|regulation of synaptic plasticity|
|regulation of protein localization to membrane|
|hormone metabolic process|
|mitochondrial transport|
|negative regulation of neuron differentiation|
|protein domain specific binding|
|regulation of ion transmembrane transporter activity|
|steroid metabolic process|
|regulation of transmembrane transporter activity|
|actin binding|
|regulation of transporter activity|
|negative regulation of neurogenesis|
|lipid catabolic process|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|positive regulation of cellular protein localization|
|response to steroid hormone|
|negative regulation of cell development|
|regulation of cation transmembrane transport|
|enzyme binding|
|regulation of metal ion transport|
|regulation of apoptotic signaling pathway|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|mitochondrion organization|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of ion transmembrane transport|
|organic cyclic compound catabolic process|
|protein heterodimerization activity|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|cellular response to lipid|
|regulation of hormone levels|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|cellular response to hormone stimulus|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of neuron differentiation|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|brain development|
|regulation of establishment of protein localization|
|head development|
|regulation of neurogenesis|
|response to lipid|
|membrane organization|
|response to hormone|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|central nervous system development|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|regulation of organelle organization|
|response to endogenous stimulus|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.71|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.7|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|2.06|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.07|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11945
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='YWHAH Expression in NALM6 Cells: 6.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>