======= ZBTB11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB11
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27107|27107]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95625|O95625]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618181|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|molecular function|
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-3.44|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-3.3|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.47|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-2.44|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.13|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.1|
|[[:results:exp169|BH1 1μM R04 exp169]]|-1.8|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-1.8|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.73|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med16|MED16]]|0.508|
|[[:human genes:t:thg1l|THG1L]]|0.472|
|[[:human genes:d:dpagt1|DPAGT1]]|0.454|
|[[:human genes:a:atp5j|ATP5J]]|0.451|
|[[:human genes:t:tsen54|TSEN54]]|0.441|
|[[:human genes:a:atp5b|ATP5B]]|0.441|
|[[:human genes:e:exoc4|EXOC4]]|0.435|
|[[:human genes:c:ccdc101|CCDC101]]|0.434|
|[[:human genes:g:gmppb|GMPPB]]|0.433|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.431|
|[[:human genes:g:gnb1l|GNB1L]]|0.43|
|[[:human genes:a:alg1|ALG1]]|0.429|
|[[:human genes:a:atp5o|ATP5O]]|0.428|
|[[:human genes:g:gfpt1|GFPT1]]|0.426|
|[[:human genes:r:rnmt|RNMT]]|0.424|
|[[:human genes:t:telo2|TELO2]]|0.416|
|[[:human genes:p:pmm2|PMM2]]|0.413|
|[[:human genes:r:rpp21|RPP21]]|0.412|
|[[:human genes:d:dad1|DAD1]]|0.41|
|[[:human genes:t:tcf4|TCF4]]|0.406|
|[[:human genes:z:zrsr2|ZRSR2]]|0.405|
|[[:human genes:m:mbtps2|MBTPS2]]|0.404|
|[[:human genes:o:oraov1|ORAOV1]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 693/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|26/28|
|bone|26/26|
|breast|33/33|
|central nervous system|54/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|19/21|
|liver|20/20|
|lung|72/75|
|lymphocyte|14/16|
|ovary|26/26|
|pancreas|19/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|7/9|
|thyroid|1/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 767
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB11 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>