======= ZBTB18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB18
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 18
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10472|10472]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99592|Q99592]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608433|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. {ECO:0000269|PubMed:9756912}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear chromosome|
|skeletal muscle tissue development|
|skeletal muscle organ development|
|transcription coactivator activity|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|sequence-specific DNA binding|
|muscle structure development|
|DNA-binding transcription factor activity|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.85|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.72|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.74|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|1.8|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.83|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.88|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.9|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.92|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|1.96|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.97|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.11|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.11|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|2.19|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.25|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|2.43|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.54|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.55|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|2.58|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.92|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.92|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rbm38|RBM38]]|0.493|
|[[:human genes:a:anp32a|ANP32A]]|0.46|
|[[:human genes:k:kdm6a|KDM6A]]|0.423|
|[[:human genes:i:itpk1|ITPK1]]|0.413|
|[[:human genes:i:itpr1|ITPR1]]|0.413|
|[[:human genes:m:memo1|MEMO1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10328
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.32 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB18 Expression in NALM6 Cells: 6.32'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>