======= ZBTB7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZBTB7A
  * **<color #00a2e8>Official Name</color>**: zinc finger and BTB domain containing 7A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51341|51341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95365|O95365]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZBTB7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZBTB7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605878|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity). Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1- dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BTB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA-dependent protein kinase complex|
|double-strand break repair via classical nonhomologous end joining|
|transcription corepressor binding|
|erythrocyte maturation|
|negative regulation of androgen receptor signaling pathway|
|NuRD complex|
|regulation of androgen receptor signaling pathway|
|histone acetyltransferase binding|
|erythrocyte development|
|activating transcription factor binding|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|negative regulation of Notch signaling pathway|
|androgen receptor binding|
|SMAD binding|
|regulation of transcription regulatory region DNA binding|
|double-strand break repair via nonhomologous end joining|
|site of double-strand break|
|myeloid cell development|
|non-recombinational repair|
|regulation of alternative mRNA splicing, via spliceosome|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of glycolytic process|
|erythrocyte differentiation|
|regulation of carbohydrate catabolic process|
|erythrocyte homeostasis|
|regulation of mRNA splicing, via spliceosome|
|regulation of Notch signaling pathway|
|fat cell differentiation|
|myeloid cell homeostasis|
|B cell differentiation|
|regulation of transforming growth factor beta receptor signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|regulation of DNA binding|
|anatomical structure maturation|
|regulation of RNA splicing|
|regulation of mRNA processing|
|negative regulation of cellular response to growth factor stimulus|
|positive regulation of NF-kappaB transcription factor activity|
|B cell activation|
|cell maturation|
|regulation of generation of precursor metabolites and energy|
|chromatin remodeling|
|protein localization to nucleus|
|double-strand break repair|
|homeostasis of number of cells|
|regulation of carbohydrate metabolic process|
|myeloid cell differentiation|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|lymphocyte differentiation|
|developmental maturation|
|transcription corepressor activity|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|positive regulation of DNA-binding transcription factor activity|
|regulation of cellular response to growth factor stimulus|
|regulation of mRNA metabolic process|
|leukocyte differentiation|
|regulation of binding|
|lymphocyte activation|
|regulation of DNA-binding transcription factor activity|
|regulation of small molecule metabolic process|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|DNA repair|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|immune system development|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|chromatin organization|
|protein localization to organelle|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|leukocyte activation|
|regulation of catabolic process|
|chromosome organization|
|cell activation|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|RNA metabolic process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-3.12|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.84|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.82|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.76|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.62|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-2.4|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.4|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.35|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.33|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.33|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.29|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.22|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.18|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-2.15|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.15|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.1|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.06|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.05|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-2.04|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-2.04|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.02|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.98|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.97|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.91|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.91|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.85|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-1.82|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.78|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.75|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.71|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.73|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.75|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.75|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.76|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.77|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.79|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.79|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|1.8|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.83|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.89|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.94|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|1.94|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.05|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.13|
|[[:results:exp534|Trientine 500μM R08 exp534]]|2.15|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.21|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.42|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.43|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.62|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.79|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.98|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|3|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.14|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|3.31|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.39|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|3.84|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|4.68|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|5.92|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|7.73|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|7.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ikzf2|IKZF2]]|0.44|
|[[:human genes:d:ddx3x|DDX3X]]|0.44|
|[[:human genes:i:ikzf1|IKZF1]]|0.431|
|[[:human genes:p:prim1|PRIM1]]|0.421|
|[[:human genes:r:rbm26|RBM26]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15792
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZBTB7A Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>