======= ZNF217 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF217
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 217
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7764|7764]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75362|O75362]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF217&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF217|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602967|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:16203743, ECO:0000269|PubMed:16940172, ECO:0000269|PubMed:17259635, ECO:0000269|PubMed:18625718}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase complex|
|transcription regulatory region DNA binding|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|nuclear speck|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|DNA-binding transcription factor activity|
|negative regulation of transcription by RNA polymerase II|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.15|
|[[:results:exp124|GSK343 3μM R03 exp124]]|-1.95|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.93|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.84|
|[[:results:exp262|Alda-1 10μM R06 exp262]]|1.74|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.77|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|1.77|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.78|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|1.79|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.81|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.84|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.89|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|1.89|
|[[:results:exp358|FK-506 5μM R07 exp358]]|1.91|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.13|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.16|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.19|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|2.23|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.25|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.29|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|2.33|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.45|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.53|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|3.03|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|3.15|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|5.37|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|5.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tnfrsf10b|TNFRSF10B]]|0.426|
|[[:human genes:i:ikzf2|IKZF2]]|0.424|
|[[:human genes:c:creb1|CREB1]]|0.41|
|[[:human genes:u:ube2e1|UBE2E1]]|0.406|
|[[:human genes:f:fnip1|FNIP1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 97/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|7/28|
|bone|0/25|
|breast|11/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|2/21|
|liver|4/20|
|lung|8/75|
|lymphocyte|0/14|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|1/24|
|soft tissue|1/7|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2540
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF217 Expression in NALM6 Cells: 7.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>