======= ZNF335 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF335
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 335
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63925|63925]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H4Z2|Q9H4Z2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF335&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF335|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610827|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. {ECO:0000269|PubMed:12215545, ECO:0000269|PubMed:18180299, ECO:0000269|PubMed:23178126}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-K4 trimethylation|
|positive regulation of neuroblast proliferation|
|cerebral cortex neuron differentiation|
|regulation of histone H3-K4 methylation|
|peptidyl-lysine trimethylation|
|regulation of neuroblast proliferation|
|brain morphogenesis|
|RNA polymerase II core promoter sequence-specific DNA binding|
|histone H3-K4 methylation|
|positive regulation of stem cell proliferation|
|histone methyltransferase complex|
|positive regulation of neural precursor cell proliferation|
|regulation of histone methylation|
|regulation of stem cell proliferation|
|histone lysine methylation|
|regulation of neural precursor cell proliferation|
|peptidyl-lysine methylation|
|histone methylation|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|protein alkylation|
|protein methylation|
|positive regulation of leukocyte proliferation|
|regulation of histone modification|
|central nervous system neuron differentiation|
|regulation of chromatin organization|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|transcription regulatory region DNA binding|
|regulation of leukocyte proliferation|
|regulation of gene expression, epigenetic|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|regulation of chromosome organization|
|positive regulation of lymphocyte activation|
|histone modification|
|covalent chromatin modification|
|in utero embryonic development|
|forebrain development|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|regulation of lymphocyte activation|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of leukocyte activation|
|chordate embryonic development|
|regulation of cell activation|
|embryo development ending in birth or egg hatching|
|neuron projection development|
|chromatin organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|chromosome organization|
|plasma membrane bounded cell projection organization|
|positive regulation of immune system process|
|cell projection organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|generation of neurons|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.91|
|[[:results:exp135|MS023 7μM R03 exp135]]|-1.88|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.88|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.81|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.73|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.71|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.71|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.75|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.78|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|1.84|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.86|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2|
|[[:results:exp461|BS-181 20μM R08 exp461]]|2.03|
|[[:results:exp303|39°C R06 exp303]]|2.1|
|[[:results:exp73|LJH685 5μM R02 exp73]]|2.1|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.19|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.26|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|2.31|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpl37a|RPL37A]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|1/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|2/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1255
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF335 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>