======= ZNF365 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF365
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 365
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22891|22891]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"Q70YC4|Q70YC5"|"Q70YC4|Q70YC5"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF365&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF365|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607818|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of DNA strand resection involved in replication fork processing|
|cerebellar molecular layer development|
|cerebellar molecular layer morphogenesis|
|dendrite arborization|
|neuron projection arborization|
|dendritic spine morphogenesis|
|positive regulation of oligodendrocyte differentiation|
|dendritic spine development|
|cerebellar cortex morphogenesis|
|dendritic spine organization|
|cerebellum morphogenesis|
|regulation of oligodendrocyte differentiation|
|neuron projection organization|
|hindbrain morphogenesis|
|positive regulation of glial cell differentiation|
|cerebellar cortex development|
|regulation of double-strand break repair via homologous recombination|
|regulation of DNA-dependent DNA replication|
|dendrite morphogenesis|
|regulation of glial cell differentiation|
|positive regulation of gliogenesis|
|regulation of double-strand break repair|
|postsynapse organization|
|telomere maintenance|
|telomere organization|
|dendrite development|
|cerebellum development|
|regulation of DNA recombination|
|regulation of DNA replication|
|metencephalon development|
|regulation of gliogenesis|
|regulation of DNA repair|
|hindbrain development|
|negative regulation of neuron projection development|
|microtubule organizing center|
|negative regulation of cell projection organization|
|regulation of response to DNA damage stimulus|
|negative regulation of neuron differentiation|
|synapse organization|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|negative regulation of cell development|
|anatomical structure homeostasis|
|regulation of DNA metabolic process|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|intracellular membrane-bounded organelle|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|regulation of cellular response to stress|
|brain development|
|DNA metabolic process|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|chromosome organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of developmental process|
|regulation of response to stress|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.81|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8399
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF365 Expression in NALM6 Cells: 0.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>