======= ZNF592 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNF592
  * **<color #00a2e8>Official Name</color>**: zinc finger protein 592
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9640|9640]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92610|Q92610]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNF592&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNF592|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613624|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be involved in transcriptional regulation.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|DNA binding|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|-1.74|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.72|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.73|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.76|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.77|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.78|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.79|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.8|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.86|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.89|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.94|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.97|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|2.02|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.1|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.13|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.17|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.23|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.25|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.29|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.33|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.34|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.35|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.4|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|2.42|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.5|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.73|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|2.95|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.13|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|3.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:med23|MED23]]|0.619|
|[[:human genes:w:wdr24|WDR24]]|0.582|
|[[:human genes:b:brpf1|BRPF1]]|0.574|
|[[:human genes:i:id3|ID3]]|0.573|
|[[:human genes:t:trim28|TRIM28]]|0.563|
|[[:human genes:m:mllt1|MLLT1]]|0.559|
|[[:human genes:f:fbxo11|FBXO11]]|0.552|
|[[:human genes:m:med13l|MED13L]]|0.551|
|[[:human genes:r:rptor|RPTOR]]|0.512|
|[[:human genes:d:dohh|DOHH]]|0.508|
|[[:human genes:c:ctdspl2|CTDSPL2]]|0.498|
|[[:human genes:m:maml1|MAML1]]|0.495|
|[[:human genes:a:actb|ACTB]]|0.492|
|[[:human genes:b:bap1|BAP1]]|0.491|
|[[:human genes:c:ccdc101|CCDC101]]|0.483|
|[[:human genes:n:nsd1|NSD1]]|0.483|
|[[:human genes:t:taf5l|TAF5L]]|0.476|
|[[:human genes:z:zmynd8|ZMYND8]]|0.475|
|[[:human genes:u:usp22|USP22]]|0.465|
|[[:human genes:s:setdb1|SETDB1]]|0.463|
|[[:human genes:m:med13|MED13]]|0.463|
|[[:human genes:t:trim33|TRIM33]]|0.46|
|[[:human genes:m:mtor|MTOR]]|0.456|
|[[:human genes:a:atf7ip|ATF7IP]]|0.451|
|[[:human genes:z:znf608|ZNF608]]|0.45|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.445|
|[[:human genes:s:sp3|SP3]]|0.44|
|[[:human genes:c:celf1|CELF1]]|0.44|
|[[:human genes:s:spin1|SPIN1]]|0.438|
|[[:human genes:t:tle4|TLE4]]|0.436|
|[[:human genes:c:cbfb|CBFB]]|0.435|
|[[:human genes:h:hhex|HHEX]]|0.431|
|[[:human genes:k:khdrbs1|KHDRBS1]]|0.431|
|[[:human genes:s:sox7|SOX7]]|0.426|
|[[:human genes:k:kat2a|KAT2A]]|0.426|
|[[:human genes:w:wdr59|WDR59]]|0.424|
|[[:human genes:m:mios|MIOS]]|0.423|
|[[:human genes:v:vhl|VHL]]|0.421|
|[[:human genes:e:ehmt2|EHMT2]]|0.42|
|[[:human genes:r:runx1|RUNX1]]|0.419|
|[[:human genes:t:thoc6|THOC6]]|0.413|
|[[:human genes:s:supt7l|SUPT7L]]|0.413|
|[[:human genes:s:slc4a7|SLC4A7]]|0.412|
|[[:human genes:m:med16|MED16]]|0.41|
|[[:human genes:m:mlst8|MLST8]]|0.409|
|[[:human genes:s:scaf8|SCAF8]]|0.406|
|[[:human genes:e:elf2|ELF2]]|0.406|
|[[:human genes:f:fli1|FLI1]]|0.404|
|[[:human genes:s:sirt7|SIRT7]]|0.403|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.401|
|[[:human genes:a:ahcyl1|AHCYL1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 517
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNF592 Expression in NALM6 Cells: 6.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>