======= ZNHIT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZNHIT3
  * **<color #00a2e8>Official Name</color>**: zinc finger HIT-type containing 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9326|9326]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15649|Q15649]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZNHIT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZNHIT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604500|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-HIT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|snoRNA localization|
|pre-snoRNP complex|
|box C/D snoRNP assembly|
|small nucleolar ribonucleoprotein complex assembly|
|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of LSU-rRNA|
|thyroid hormone receptor binding|
|ribosomal large subunit biogenesis|
|rRNA processing|
|RNA localization|
|rRNA metabolic process|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|protein-containing complex assembly|
|RNA metabolic process|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.73|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|1.74|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.76|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.91|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.11|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.61|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 187/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|2/28|
|bone|6/26|
|breast|7/33|
|central nervous system|21/56|
|cervix|2/4|
|colorectal|4/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|9/21|
|liver|8/20|
|lung|12/75|
|lymphocyte|2/16|
|ovary|7/26|
|pancreas|3/24|
|peripheral nervous system|5/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|9/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZNHIT3 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>