======= ZYX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ZYX
  * **<color #00a2e8>Official Name</color>**: zyxin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7791|7791]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15942|Q15942]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ZYX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ZYX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602002|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|stress fiber assembly|
|contractile actin filament bundle assembly|
|phagocytic vesicle|
|actin filament bundle assembly|
|actin filament bundle organization|
|stress fiber|
|integrin-mediated signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|cell-cell adherens junction|
|actomyosin structure organization|
|cell-matrix adhesion|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|cell-substrate adhesion|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|actin filament organization|
|regulation of inflammatory response|
|focal adhesion|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|cellular response to growth factor stimulus|
|response to growth factor|
|actin filament-based process|
|viral process|
|enzyme linked receptor protein signaling pathway|
|regulation of defense response|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|cellular response to cytokine stimulus|
|regulation of response to external stimulus|
|response to cytokine|
|cytoskeleton organization|
|cell-cell signaling|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|response to endogenous stimulus|
|regulation of response to stress|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.78|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|1.7|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.73|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8339
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ZYX Expression in NALM6 Cells: 1.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>