====== R-DABN 8μM R03 exp111 ======
==== Mechanism of Action ====
Unknown, (R) atropisomer of 1,1'-Binaphthyl-2,2'-diamine
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%[1,1'-Binaphthalene]-2,2'-diamine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 18741-85-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/20571|20571]]
    * **<color #00a2e8>IUPAC:</color>** %%1-(2-aminonaphthalen-1-yl)naphthalen-2-amine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2
    * **<color #00a2e8>INCHI Key:</color>** DDAPSNKEOHDLKB-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 284.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H16N2
{{:chemogenomics:structures:chem-0067.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Chem-Impex International
    * **<color #00a2e8>Catalog #:</color>** 24622
    * **<color #00a2e8>Lot #:</color>** 001702-20130307
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H16N2 285.13862; found 285.13901
</panel>


<panel title='Dose Response Curve'>
Dose response curve not available.
</panel>


</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 8µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.9
    * **<color #00a2e8>Numbers of reads</color>**: 13572519


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/102|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/R-DABN_8uM_Round-3_exp111.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='R-DABN 8μM R03 exp111'>
{{:chemogenomics:cranks_plots:exp111.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:M:MS4A13|MS4A13]]|-2.92|0.52|
|[[:human_genes:C:CCDC42B|CCDC42B]]|-2.67|0.19|
|[[:human_genes:G:GET4|GET4]]|-2.59|0.19|
|[[:human_genes:O:OTOS|OTOS]]|-2.40|0.24|
|[[:human_genes:A:AQR|AQR]]|-2.38|0.50|
|[[:human_genes:K:KRTAP5-4|KRTAP5-4]]|-2.28|0.43|
|[[:human_genes:H:HHLA3|HHLA3]]|-2.28|0.35|
|[[:human_genes:T:TSC2|TSC2]]|-2.25|0.35|
|[[:human_genes:Z:ZBTB48|ZBTB48]]|-2.22|0.35|
|[[:human_genes:A:AHCTF1|AHCTF1]]|-2.22|0.50|
|[[:human_genes:R:RANBP1|RANBP1]]|-2.21|0.35|
|[[:human_genes:T:TRAPPC4|TRAPPC4]]|-2.19|0.35|
|[[:human_genes:W:WDR7|WDR7]]|-2.18|0.35|
|[[:human_genes:F:FAM120A|FAM120A]]|-2.15|0.35|
|[[:human_genes:D:DNA2|DNA2]]|-2.13|0.52|
|[[:human_genes:C:C5orf45|C5orf45]]|-2.12|0.35|
|[[:human_genes:R:RGMA|RGMA]]|-2.11|0.35|
|[[:human_genes:C:CHMP1A|CHMP1A]]|-2.10|0.46|
|[[:human_genes:P:PLEC|PLEC]]|-2.10|0.35|
|[[:human_genes:M:MED12|MED12]]|-2.07|0.55|
|[[:human_genes:C:COG4|COG4]]|-2.07|0.35|
|[[:human_genes:N:NAPA|NAPA]]|-2.06|0.50|
|[[:human_genes:T:TAS2R40|TAS2R40]]|-2.06|0.35|
|[[:human_genes:F:FAM227A|FAM227A]]|-2.06|0.46|
|[[:human_genes:D:DTYMK|DTYMK]]|-2.01|0.63|
|[[:human_genes:P:PSMB2|PSMB2]]|-2.00|0.63|
|[[:human_genes:C:CRISPLD2|CRISPLD2]]|-1.96|0.46|
|[[:human_genes:S:SLC22A14|SLC22A14]]|-1.96|0.52|
|[[:human_genes:C:CDC7|CDC7]]|-1.95|0.46|
|[[:human_genes:C:CMIP|CMIP]]|-1.95|0.46|
|[[:human_genes:F:FBXL18|FBXL18]]|3.29|<0.01|
|[[:human_genes:R:RNF216|RNF216]]|3.30|<0.01|
|[[:human_genes:H:HERPUD2|HERPUD2]]|3.31|<0.01|
|[[:human_genes:C:CYTH3|CYTH3]]|3.32|<0.01|
|[[:human_genes:A:AP5Z1|AP5Z1]]|3.32|<0.01|
|[[:human_genes:A:AMZ1|AMZ1]]|3.33|<0.01|
|[[:human_genes:F:FERD3L|FERD3L]]|3.34|<0.01|
|[[:human_genes:R:RSPH10B|RSPH10B]]|3.38|<0.01|
|[[:human_genes:T:TMEM196|TMEM196]]|3.50|<0.01|
|[[:human_genes:H:HOXA2|HOXA2]]|3.58|<0.01|
|[[:human_genes:P:PRR15|PRR15]]|3.59|<0.01|
|[[:human_genes:R:RSPH10B2|RSPH10B2]]|3.62|<0.01|
|[[:human_genes:P:PSPH|PSPH]]|3.70|<0.01|
|[[:human_genes:M:MEOX2|MEOX2]]|3.75|<0.01|
|[[:human_genes:A:ADCYAP1R1|ADCYAP1R1]]|3.75|<0.01|
|[[:human_genes:F:FNTB|FNTB]]|3.75|<0.01|
|[[:human_genes:R:RBM14-RBM4|RBM14-RBM4]]|3.80|<0.01|
|[[:human_genes:R:RBM14|RBM14]]|3.87|<0.01|
|[[:human_genes:U:USP42|USP42]]|4.18|<0.01|
|[[:human_genes:I:ITGB8|ITGB8]]|4.25|<0.01|
|[[:human_genes:C:CDC20|CDC20]]|4.51|<0.01|
|[[:human_genes:M:MAD2L1BP|MAD2L1BP]]|5.07|<0.01|
|[[:human_genes:M:MAD2L1|MAD2L1]]|5.14|<0.01|
|[[:human_genes:Z:ZWILCH|ZWILCH]]|5.22|<0.01|
|[[:human_genes:B:BUB1B|BUB1B]]|5.53|<0.01|
|[[:human_genes:M:MAD1L1|MAD1L1]]|5.56|<0.01|
|[[:human_genes:B:BUB3|BUB3]]|5.89|<0.01|
|[[:human_genes:Z:ZW10|ZW10]]|8.03|<0.01|
|[[:human_genes:T:TRIP13|TRIP13]]|8.19|<0.01|
|[[:human_genes:K:KNTC1|KNTC1]]|8.27|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp33|Rotenone 2μM R00 exp33]]|0.256|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|0.227|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|0.169|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.106|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|0.286|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|0.262|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|0.245|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|0.189|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|0.18|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.121|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.071|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.064|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.053|<button type="primary" size="small" modal="13">View</button>|
</modal>


<modal id="1" size="lg" title="R-DABN 8μM R03 exp111  vs  Rotenone 2μM R00 exp33">
{{:chemogenomics:comparison_plots:exp111_vs_exp33.png?nolink |}}
</modal>

<modal id="2" size="lg" title="R-DABN 8μM R03 exp111  vs  SB743921 0.001μM R05 exp244">
{{:chemogenomics:comparison_plots:exp111_vs_exp244.png?nolink |}}
</modal>

<modal id="3" size="lg" title="R-DABN 8μM R03 exp111  vs  Vinblastine 0.015μM R05 exp208">
{{:chemogenomics:comparison_plots:exp111_vs_exp208.png?nolink |}}
</modal>

<modal id="4" size="lg" title="R-DABN 8μM R03 exp111  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp111.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Nocodazole 0.1μM R03 exp94  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp94.png?nolink |}}
</modal>

<modal id="6" size="lg" title="DABN racemic mixture R03 exp93  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp93.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Nocodazole 0.2μM R00 exp24  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp24.png?nolink |}}
</modal>

<modal id="8" size="lg" title="HMS-I1 10μM R06 exp256  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp256.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Nocodazole 0.2μM R02 exp64  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp64.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BI-6727 0.04μM R03 exp98  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp98.png?nolink |}}
</modal>

<modal id="11" size="lg" title="BI-2536 0.02μM R03 exp96  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp96.png?nolink |}}
</modal>

<modal id="12" size="lg" title="GSK461364A 0.1μM R03 exp126  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp126.png?nolink |}}
</modal>

<modal id="13" size="lg" title="DABN 20μM R00 exp17  vs  R-DABN 8μM R03 exp111">
{{:chemogenomics:comparison_plots:exp111_vs_exp17.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|mitotic spindle checkpoint signaling|177.63|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|mitotic spindle assembly checkpoint signaling|177.63|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|spindle assembly checkpoint signaling|177.63|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|negative regulation of mitotic sister chromatid segregation|160.44|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|negative regulation of mitotic sister chromatid separation|160.44|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|spindle checkpoint signaling|152.45|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,CDC20|
|negative regulation of metaphase/anaphase transition of cell cycle|150.72|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|negative regulation of chromosome segregation|150.72|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|negative regulation of chromosome separation|150.72|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|negative regulation of sister chromatid segregation|142.62|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,CDC20|
|negative regulation of mitotic metaphase/anaphase transition|142.62|KNTC1,TRIP13,ZW10,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|negative regulation of nuclear division|108.12|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,CDC20|
|regulation of mitotic sister chromatid segregation|93.84|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP|
|regulation of mitotic sister chromatid separation|85.75|TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20|
|regulation of chromosome separation|75.70|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20|
|regulation of mitotic metaphase/anaphase transition|62.09|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20|
|regulation of metaphase/anaphase transition of cell cycle|60.07|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20|
|regulation of mitotic nuclear division|51.96|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20,HOXA13|
|regulation of nuclear division|42.22|KNTC1,TRIP13,ZW10,BUB3,MAD1L1,BUB1B,ZWILCH,MAD2L1,MAD2L1BP,CDC20,HOXA13|
</modal>