====== Resveratrol 16μM R03 exp147 ======
==== Mechanism of Action ====
Putative sirtuin activator, many other ascribed activities, analog of pterostilbene
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Activator




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Resveratrol%%
    * **<color #00a2e8>Synonyms:</color>** SRT 501; trans-Resveratrol
    * **<color #00a2e8>CAS #:</color>** 501-36-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/445154|445154]]
    * **<color #00a2e8>IUPAC:</color>** %%5-[(E)-2-(4-hydroxyphenyl)ethenyl]benzene-1,3-diol%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+
    * **<color #00a2e8>INCHI Key:</color>** LUKBXSAWLPMMSZ-OWOJBTEDSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 228.24
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC(=CC=C1C=CC2=CC(=CC(=C2)O)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C1=CC(=CC=C1/C=C/C2=CC(=CC(=C2)O)O)O
    * **<color #00a2e8>Molecular Formula:</color>** C14H12O3
{{:chemogenomics:structures:chem-0098.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Toronto Research Chemicals
    * **<color #00a2e8>Catalog #:</color>** R150000
    * **<color #00a2e8>Lot #:</color>** 2-ZNL-10-1
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C14H12O3 229.08592; found 229.086
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** RESVERATROL
    * **<color #00a2e8>Min:</color>** 2.6734; **<color #00a2e8>Max:</color>** 95.8148
{{:chemogenomics:dose_response:dr_116.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |9.7877    |
| IC30  |14.8061    |
| IC40  |20.7871    |
| IC50  |28.3805    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 16µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 4.8
    * **<color #00a2e8>Numbers of reads</color>**: 12942673


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|12/4|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Resveratrol_16uM_Round-3_exp147.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Resveratrol 16μM R03 exp147'>
{{:chemogenomics:cranks_plots:exp147.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ACSL4|ACSL4]]|-4.53|<0.01|
|[[:human_genes:G:GTPBP2|GTPBP2]]|-3.79|<0.01|
|[[:human_genes:R:RNASEH2B|RNASEH2B]]|-3.08|<0.01|
|[[:human_genes:T:TKTL1|TKTL1]]|-3.06|<0.01|
|[[:human_genes:H:HGC6.3|HGC6.3]]|-2.97|0.30|
|[[:human_genes:R:RECQL5|RECQL5]]|-2.95|0.01|
|[[:human_genes:R:RNASEH2A|RNASEH2A]]|-2.87|0.03|
|[[:human_genes:K:KPNA3|KPNA3]]|-2.83|0.02|
|[[:human_genes:K:KPNA4|KPNA4]]|-2.77|0.01|
|[[:human_genes:A:ADIPOR2|ADIPOR2]]|-2.76|0.01|
|[[:human_genes:G:GTPBP1|GTPBP1]]|-2.72|0.03|
|[[:human_genes:R:RBM5|RBM5]]|-2.66|0.02|
|[[:human_genes:K:KDSR|KDSR]]|-2.55|0.03|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.40|0.08|
|[[:human_genes:M:MKLN1|MKLN1]]|-2.39|0.06|
|[[:human_genes:A:ATP5J|ATP5J]]|-2.36|0.06|
|[[:human_genes:Y:YWHAE|YWHAE]]|-2.35|0.06|
|[[:human_genes:M:MAEA|MAEA]]|-2.34|0.06|
|[[:human_genes:R:RING1|RING1]]|-2.32|0.10|
|[[:human_genes:P:PPIL1|PPIL1]]|-2.32|0.16|
|[[:human_genes:R:RANBP1|RANBP1]]|-2.31|0.06|
|[[:human_genes:M:MAN2B1|MAN2B1]]|-2.31|0.06|
|[[:human_genes:N:NEK5|NEK5]]|-2.29|0.11|
|[[:human_genes:G:GLRX3|GLRX3]]|-2.26|0.08|
|[[:human_genes:C:CDKN2AIP|CDKN2AIP]]|-2.25|0.08|
|[[:human_genes:C:CCDC111|CCDC111]]|-2.22|0.09|
|[[:human_genes:W:WDR26|WDR26]]|-2.20|0.15|
|[[:human_genes:H:HIST1H3E|HIST1H3E]]|-2.19|0.10|
|[[:human_genes:S:SNF8|SNF8]]|-2.19|0.16|
|[[:human_genes:T:TCF4|TCF4]]|-2.18|0.23|
|[[:human_genes:S:SFXN4|SFXN4]]|2.17|0.19|
|[[:human_genes:U:USP37|USP37]]|2.18|0.25|
|[[:human_genes:P:PNISR|PNISR]]|2.18|0.18|
|[[:human_genes:Z:ZC3H7A|ZC3H7A]]|2.18|0.15|
|[[:human_genes:R:RBPJ|RBPJ]]|2.18|0.18|
|[[:human_genes:C:COPZ1|COPZ1]]|2.18|0.32|
|[[:human_genes:T:TCTE3|TCTE3]]|2.19|0.18|
|[[:human_genes:N:NRAS|NRAS]]|2.20|0.14|
|[[:human_genes:A:AGMO|AGMO]]|2.22|0.14|
|[[:human_genes:R:RBM7|RBM7]]|2.22|0.24|
|[[:human_genes:C:CLEC2D|CLEC2D]]|2.22|0.14|
|[[:human_genes:M:MAK16|MAK16]]|2.24|0.18|
|[[:human_genes:F:FBXO48|FBXO48]]|2.25|0.13|
|[[:human_genes:B:BTBD9|BTBD9]]|2.26|0.21|
|[[:human_genes:M:MRPS7|MRPS7]]|2.27|0.27|
|[[:human_genes:O:OR3A2|OR3A2]]|2.29|0.15|
|[[:human_genes:S:SLFN11|SLFN11]]|2.32|0.10|
|[[:human_genes:G:GLRX5|GLRX5]]|2.33|0.18|
|[[:human_genes:R:RPL10|RPL10]]|2.35|0.18|
|[[:human_genes:Z:ZNF587B|ZNF587B]]|2.42|0.12|
|[[:human_genes:D:DPH6|DPH6]]|2.45|0.06|
|[[:human_genes:Z:ZNF266|ZNF266]]|2.45|0.06|
|[[:human_genes:Z:ZNF330|ZNF330]]|2.54|0.08|
|[[:human_genes:S:SESTD1|SESTD1]]|2.57|0.05|
|[[:human_genes:A:ASXL2|ASXL2]]|2.66|0.06|
|[[:human_genes:R:RBM25|RBM25]]|2.74|0.07|
|[[:human_genes:G:GCN1L1|GCN1L1]]|2.76|0.02|
|[[:human_genes:M:MCAT|MCAT]]|2.77|0.02|
|[[:human_genes:P:PI4KB|PI4KB]]|2.88|0.02|
|[[:human_genes:P:PPP3R1|PPP3R1]]|3.59|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|0.052|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|0.051|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|0.123|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|0.079|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.076|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|0.076|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.057|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.055|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|0.054|<button type="primary" size="small" modal="9">View</button>|
</modal>


<modal id="1" size="lg" title="Resveratrol 16μM R03 exp147  vs  Rucaparib 6.5μM R08 exp520">
{{:chemogenomics:comparison_plots:exp147_vs_exp520.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Resveratrol 16μM R03 exp147  vs  Trimetrexate 0.03μM R08 exp535">
{{:chemogenomics:comparison_plots:exp147_vs_exp535.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Pterostilbene 16μM R02 exp78  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp78.png?nolink |}}
</modal>

<modal id="4" size="lg" title="MK-1775 0.32μM R02 exp75  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp75.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp440.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Hydroxyurea 100μM R07 exp329  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp329.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Diepoxybutane 3μM R07 exp354  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp354.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Olaparib 4μM R08 exp512  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp512.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Quercetin 20μM R08 exp517  vs  Resveratrol 16μM R03 exp147">
{{:chemogenomics:comparison_plots:exp147_vs_exp517.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>