====== SGC0649 7μM R03 exp150 ======
==== Mechanism of Action ====
Inactive control for SGC0649 (DOT1L methyltransferase inhibitor)
  * **<color #00a2e8>Class / Subclass 1:</color>** Gene Regulation / Epigenetic Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 603.56
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C28H39N6O4Br
{{:chemogenomics:structures:chem-0101.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Structural Genomics Consortium
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C28H39BrN6O4 603.22889; found 603.22937
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** SGC0649
    * **<color #00a2e8>Min:</color>** -7.3456; **<color #00a2e8>Max:</color>** 19.7209
{{:chemogenomics:dose_response:dr_121.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 03
    * **<color #00a2e8>Dose</color>**: 7µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 8.1
    * **<color #00a2e8>Numbers of reads</color>**: 11099781


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/SGC0649_7uM_Round-3_exp150.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='SGC0649 7μM R03 exp150'>
{{:chemogenomics:cranks_plots:exp150.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:PCDHGA11|PCDHGA11]]|-2.76|0.22|
|[[:human_genes:G:GCLC|GCLC]]|-2.46|0.37|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.45|0.45|
|[[:human_genes:E:ENO1|ENO1]]|-2.44|0.45|
|[[:human_genes:R:RALGAPA2|RALGAPA2]]|-2.35|0.37|
|[[:human_genes:S:SNAPC5|SNAPC5]]|-2.21|0.45|
|[[:human_genes:R:RAB1B|RAB1B]]|-2.17|0.45|
|[[:human_genes:F:FEN1|FEN1]]|-2.16|0.45|
|[[:human_genes:P:PUS1|PUS1]]|-2.16|0.45|
|[[:human_genes:C:CCNB3|CCNB3]]|-2.15|0.45|
|[[:human_genes:P:PDK3|PDK3]]|-2.14|0.45|
|[[:human_genes:S:SEC16A|SEC16A]]|-2.11|0.62|
|[[:human_genes:E:EIF3M|EIF3M]]|-2.10|0.45|
|[[:human_genes:P:PRAMEF10|PRAMEF10]]|-2.06|0.45|
|[[:human_genes:L:LOC403312|LOC403312]]|-2.04|0.59|
|[[:human_genes:R:RAB24|RAB24]]|-2.03|0.45|
|[[:human_genes:P:PYROXD1|PYROXD1]]|-2.02|0.82|
|[[:human_genes:L:LMX1B|LMX1B]]|-2.00|0.62|
|[[:human_genes:M:MICU3|MICU3]]|-1.99|0.49|
|[[:human_genes:P:PRR14L|PRR14L]]|-1.98|0.62|
|[[:human_genes:N:NDRG4|NDRG4]]|-1.97|0.51|
|[[:human_genes:P:PIK3C3|PIK3C3]]|-1.96|0.62|
|[[:human_genes:P:PRTG|PRTG]]|-1.92|0.59|
|[[:human_genes:F:FDPS|FDPS]]|-1.92|0.72|
|[[:human_genes:H:HBP1|HBP1]]|-1.90|0.62|
|[[:human_genes:C:CCDC155|CCDC155]]|-1.88|0.65|
|[[:human_genes:I:ITGB8|ITGB8]]|-1.88|0.65|
|[[:human_genes:M:MNAT1|MNAT1]]|-1.88|0.65|
|[[:human_genes:G:GRIN2B|GRIN2B]]|-1.86|0.62|
|[[:human_genes:D:DRD5|DRD5]]|-1.86|0.67|
|[[:human_genes:S:SORCS1|SORCS1]]|1.91|0.62|
|[[:human_genes:N:NDC80|NDC80]]|1.91|0.86|
|[[:human_genes:C:CCDC94|CCDC94]]|1.91|0.84|
|[[:human_genes:C:CACNA1E|CACNA1E]]|1.93|0.62|
|[[:human_genes:M:MARS|MARS]]|1.93|0.75|
|[[:human_genes:T:TRIM37|TRIM37]]|1.95|0.60|
|[[:human_genes:N:NPRL3|NPRL3]]|1.95|0.83|
|[[:human_genes:T:TCTN2|TCTN2]]|1.95|0.72|
|[[:human_genes:N:NSF|NSF]]|1.97|0.72|
|[[:human_genes:N:NGLY1|NGLY1]]|1.98|0.55|
|[[:human_genes:U:UTP11L|UTP11L]]|1.99|0.72|
|[[:human_genes:D:DLX2|DLX2]]|2.00|0.55|
|[[:human_genes:D:DDX54|DDX54]]|2.04|0.72|
|[[:human_genes:U:USP11|USP11]]|2.04|0.51|
|[[:human_genes:K:KIDINS220|KIDINS220]]|2.10|0.51|
|[[:human_genes:P:PSMC4|PSMC4]]|2.15|0.72|
|[[:human_genes:H:HOXA13|HOXA13]]|2.16|0.51|
|[[:human_genes:R:RANBP2|RANBP2]]|2.16|0.51|
|[[:human_genes:Z:ZNF841|ZNF841]]|2.23|0.49|
|[[:human_genes:C:CAB39|CAB39]]|2.24|0.51|
|[[:human_genes:S:STK38|STK38]]|2.24|0.55|
|[[:human_genes:A:APBA1|APBA1]]|2.27|0.51|
|[[:human_genes:U:USP39|USP39]]|2.30|0.51|
|[[:human_genes:C:CFHR4|CFHR4]]|2.39|0.38|
|[[:human_genes:N:NPIPB3|NPIPB3]]|2.44|0.72|
|[[:human_genes:H:HSPE1|HSPE1]]|2.47|0.63|
|[[:human_genes:R:RARS|RARS]]|2.80|0.72|
|[[:human_genes:T:TMSB15B|TMSB15B]]|3.02|0.51|
|[[:human_genes:P:PRPF18|PRPF18]]|3.06|0.44|
|[[:human_genes:P:PLK4|PLK4]]|3.28|0.38|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|0.056|<button type="primary" size="small" modal="1">View</button>|
</modal>


<modal id="1" size="lg" title="Nicotinamide 1000μM R03 exp101  vs  SGC0649 7μM R03 exp150">
{{:chemogenomics:comparison_plots:exp101_vs_exp150.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>