====== DABN 2μM R00 exp16 ======
==== Mechanism of Action ====
Unknown
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%[1,1'-Binaphthalene]-2,2'-diamine%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 4488-22-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/20571|20571]]
    * **<color #00a2e8>IUPAC:</color>** %%1-(2-aminonaphthalen-1-yl)naphthalen-2-amine%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C20H16N2/c21-17-11-9-13-5-1-3-7-15(13)19(17)20-16-8-4-2-6-14(16)10-12-18(20)22/h1-12H,21-22H2
    * **<color #00a2e8>INCHI Key:</color>** DDAPSNKEOHDLKB-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 284.4
    * **<color #00a2e8>Canonical SMILES:</color>** C1=CC=C2C(=C1)C=CC(=C2C3=C(C=CC4=CC=CC=C43)N)N
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C20H16N2
{{:chemogenomics:structures:chem-0009.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Chem-Impex International
    * **<color #00a2e8>Catalog #:</color>** 24623
    * **<color #00a2e8>Lot #:</color>** 001702-20140303
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C20H16N2 285.13862; found 285.13894
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** DABN
    * **<color #00a2e8>Min:</color>** -10.2228; **<color #00a2e8>Max:</color>** 85.8979
{{:chemogenomics:dose_response:dr_262.png?nolink&500 |}}
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |6.0249    |
| IC30  |6.1377    |
| IC40  |6.2318    |
| IC50  |6.3193    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 00
    * **<color #00a2e8>Dose</color>**: 2µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.4
    * **<color #00a2e8>Numbers of reads</color>**: 10428304


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|1/1|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/DABN_2uM_Round-0_exp16.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='DABN 2μM R00 exp16'>
{{:chemogenomics:cranks_plots:exp16.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ASB3|ASB3]]|-2.86|0.05|
|[[:human_genes:O:ORC3|ORC3]]|-2.50|0.42|
|[[:human_genes:C:CEPT1|CEPT1]]|-2.45|0.24|
|[[:human_genes:S:SENP6|SENP6]]|-2.39|0.24|
|[[:human_genes:T:TRPM4|TRPM4]]|-2.36|0.42|
|[[:human_genes:D:DCAF15|DCAF15]]|-2.28|0.43|
|[[:human_genes:C:COX8C|COX8C]]|-2.18|0.43|
|[[:human_genes:P:PARL|PARL]]|-2.15|0.43|
|[[:human_genes:L:LMLN|LMLN]]|-2.11|0.43|
|[[:human_genes:O:OR4F4|OR4F4]]|-2.08|0.43|
|[[:human_genes:N:NUDT5|NUDT5]]|-2.08|0.43|
|[[:human_genes:V:VAC14|VAC14]]|-2.05|0.43|
|[[:human_genes:R:RAB11FIP3|RAB11FIP3]]|-2.03|0.43|
|[[:human_genes:D:DPAGT1|DPAGT1]]|-2.03|0.43|
|[[:human_genes:T:TXNL4B|TXNL4B]]|-2.02|0.43|
|[[:human_genes:C:COX4I1|COX4I1]]|-2.01|0.43|
|[[:human_genes:N:NKX6-2|NKX6-2]]|-1.98|0.43|
|[[:human_genes:C:CRELD1|CRELD1]]|-1.98|0.64|
|[[:human_genes:S:SPRN|SPRN]]|-1.97|0.43|
|[[:human_genes:Z:ZMYND19|ZMYND19]]|-1.97|0.43|
|[[:human_genes:Z:ZNHIT1|ZNHIT1]]|-1.96|0.43|
|[[:human_genes:P:PGGT1B|PGGT1B]]|-1.95|0.43|
|[[:human_genes:S:SCFD1|SCFD1]]|-1.94|0.65|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-1.92|0.46|
|[[:human_genes:Z:ZIC2|ZIC2]]|-1.92|0.46|
|[[:human_genes:C:CHMP1A|CHMP1A]]|-1.89|0.64|
|[[:human_genes:F:FARS2|FARS2]]|-1.88|0.66|
|[[:human_genes:K:KRT6B|KRT6B]]|-1.88|0.54|
|[[:human_genes:T:TXNL4A|TXNL4A]]|-1.86|0.73|
|[[:human_genes:R:RFC5|RFC5]]|-1.86|0.58|
|[[:human_genes:R:RPS28|RPS28]]|2.13|0.52|
|[[:human_genes:R:RUVBL1|RUVBL1]]|2.13|0.52|
|[[:human_genes:M:MYO1H|MYO1H]]|2.13|0.33|
|[[:human_genes:P:PIGW|PIGW]]|2.15|0.30|
|[[:human_genes:W:WEE1|WEE1]]|2.15|0.48|
|[[:human_genes:G:GPR156|GPR156]]|2.17|0.26|
|[[:human_genes:L:LECT1|LECT1]]|2.18|0.26|
|[[:human_genes:C:CNTNAP2|CNTNAP2]]|2.21|0.26|
|[[:human_genes:R:RFC1|RFC1]]|2.25|0.50|
|[[:human_genes:C:C19orf53|C19orf53]]|2.26|0.30|
|[[:human_genes:Z:ZNF675|ZNF675]]|2.28|0.26|
|[[:human_genes:A:ADAM18|ADAM18]]|2.28|0.30|
|[[:human_genes:P:PNPLA8|PNPLA8]]|2.30|0.30|
|[[:human_genes:M:MYCBP2|MYCBP2]]|2.30|0.26|
|[[:human_genes:E:ECD|ECD]]|2.31|0.30|
|[[:human_genes:P:PSMA1|PSMA1]]|2.37|0.39|
|[[:human_genes:T:TPX2|TPX2]]|2.39|0.39|
|[[:human_genes:N:NUP188|NUP188]]|2.41|0.26|
|[[:human_genes:N:NPIPB3|NPIPB3]]|2.46|0.43|
|[[:human_genes:P:PLEKHA4|PLEKHA4]]|2.48|0.17|
|[[:human_genes:R:RPL14|RPL14]]|2.56|0.33|
|[[:human_genes:S:SPATA12|SPATA12]]|2.57|0.07|
|[[:human_genes:N:NUP93|NUP93]]|2.58|0.33|
|[[:human_genes:C:CEP76|CEP76]]|2.63|0.06|
|[[:human_genes:C:CALCOCO2|CALCOCO2]]|2.66|0.06|
|[[:human_genes:C:CKAP5|CKAP5]]|2.82|0.33|
|[[:human_genes:S:SMU1|SMU1]]|2.92|0.26|
|[[:human_genes:A:ANXA5|ANXA5]]|2.94|0.03|
|[[:human_genes:R:RPS13|RPS13]]|3.04|0.08|
|[[:human_genes:N:NDC80|NDC80]]|3.12|0.26|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|0.07|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp101|Nicotinamide 1000μM R03 exp101]]|0.057|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|0.055|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|0.052|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|0.068|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp11|CCCP 1μM R00 exp11]]|0.063|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|0.062|<button type="primary" size="small" modal="7">View</button>|
</modal>


<modal id="1" size="lg" title="DABN 2μM R00 exp16  vs  Rifampicin 10μM R00 exp32">
{{:chemogenomics:comparison_plots:exp16_vs_exp32.png?nolink |}}
</modal>

<modal id="2" size="lg" title="DABN 2μM R00 exp16  vs  Nicotinamide 1000μM R03 exp101">
{{:chemogenomics:comparison_plots:exp101_vs_exp16.png?nolink |}}
</modal>

<modal id="3" size="lg" title="DABN 2μM R00 exp16  vs  Wortmannin 0.5μM R00 exp37">
{{:chemogenomics:comparison_plots:exp16_vs_exp37.png?nolink |}}
</modal>

<modal id="4" size="lg" title="DABN 2μM R00 exp16  vs  Rapamycin 1μM R00 exp29">
{{:chemogenomics:comparison_plots:exp16_vs_exp29.png?nolink |}}
</modal>

<modal id="5" size="lg" title="5-Fluorouracil 2μM R00 exp1  vs  DABN 2μM R00 exp16">
{{:chemogenomics:comparison_plots:exp1_vs_exp16.png?nolink |}}
</modal>

<modal id="6" size="lg" title="CCCP 1μM R00 exp11  vs  DABN 2μM R00 exp16">
{{:chemogenomics:comparison_plots:exp11_vs_exp16.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Cycloheximide 0.02μM R00 exp14  vs  DABN 2μM R00 exp16">
{{:chemogenomics:comparison_plots:exp14_vs_exp16.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>