====== IU1-47 25μM R04 exp182 ======
==== Mechanism of Action ====
Inhibits USP14, enhances protein degradation by 26S proteasome
  * **<color #00a2e8>Class / Subclass 1:</color>** Proteostasis / Deubiquitinase (DUB) Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%1-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** 670270-31-2
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/675477|675477]]
    * **<color #00a2e8>IUPAC:</color>** %%1-[1-(4-chlorophenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C19H23ClN2O/c1-14-12-18(19(23)13-21-10-4-3-5-11-21)15(2)22(14)17-8-6-16(20)7-9-17/h6-9,12H,3-5,10-11,13H2,1-2H3
    * **<color #00a2e8>INCHI Key:</color>** VXQIPRWKLACSKZ-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 330.8
    * **<color #00a2e8>Canonical SMILES:</color>** CC1=CC(=C(N1C2=CC=C(C=C2)Cl)C)C(=O)CN3CCCCC3
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C19H23ClN2O
{{:chemogenomics:structures:chem-0115.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - Harvard Medical School - Daniel Finley group - Synthesized as described in Boselli and al., 2017
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C19H23ClN2O 331.15717; found 331.15787
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** IU1-47
    * **<color #00a2e8>Min:</color>** -9.7053; **<color #00a2e8>Max:</color>** 11.2758
{{:chemogenomics:dose_response:dr_225.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |N/A    |
| IC40  |N/A    |
| IC50  |N/A    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 04
    * **<color #00a2e8>Dose</color>**: 25µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 6.9
    * **<color #00a2e8>Numbers of reads</color>**: 19824688


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|8/0|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/IU1-47_25uM_Round-4_exp182.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="default" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='IU1-47 25μM R04 exp182'>
{{:chemogenomics:cranks_plots:exp182.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:F:FLVCR1|FLVCR1]]|-3.68|<0.01|
|[[:human_genes:K:KDSR|KDSR]]|-3.37|<0.01|
|[[:human_genes:S:SLC5A3|SLC5A3]]|-2.90|0.01|
|[[:human_genes:D:DCAF15|DCAF15]]|-2.89|0.03|
|[[:human_genes:R:RAB7A|RAB7A]]|-2.66|0.03|
|[[:human_genes:A:ASB3|ASB3]]|-2.54|0.05|
|[[:human_genes:D:DDI2|DDI2]]|-2.52|0.05|
|[[:human_genes:C:CHKA|CHKA]]|-2.49|0.05|
|[[:human_genes:R:RGP1|RGP1]]|-2.44|0.15|
|[[:human_genes:P:PLEKHA2|PLEKHA2]]|-2.44|0.15|
|[[:human_genes:S:SCAP|SCAP]]|-2.39|0.08|
|[[:human_genes:Z:ZMYND12|ZMYND12]]|-2.38|0.08|
|[[:human_genes:C:CEP57|CEP57]]|-2.33|0.15|
|[[:human_genes:K:KIAA1432|KIAA1432]]|-2.29|0.11|
|[[:human_genes:E:ETV6|ETV6]]|-2.28|0.11|
|[[:human_genes:D:DCPS|DCPS]]|-2.28|0.15|
|[[:human_genes:B:BNIP1|BNIP1]]|-2.28|0.11|
|[[:human_genes:C:CHD8|CHD8]]|-2.26|0.16|
|[[:human_genes:A:ASH1L|ASH1L]]|-2.24|0.13|
|[[:human_genes:P:PCYT2|PCYT2]]|-2.21|0.26|
|[[:human_genes:M:MBTPS1|MBTPS1]]|-2.20|0.27|
|[[:human_genes:S:SPCS1|SPCS1]]|-2.20|0.34|
|[[:human_genes:P:PTAR1|PTAR1]]|-2.17|0.18|
|[[:human_genes:P:PCIF1|PCIF1]]|-2.15|0.15|
|[[:human_genes:D:DBH|DBH]]|-2.15|0.27|
|[[:human_genes:T:TSSC1|TSSC1]]|-2.12|0.16|
|[[:human_genes:A:ATP2A2|ATP2A2]]|-2.11|0.37|
|[[:human_genes:P:PCDHGA9|PCDHGA9]]|-2.10|0.17|
|[[:human_genes:K:KIAA1033|KIAA1033]]|-2.10|0.24|
|[[:human_genes:P:PLBD1|PLBD1]]|-2.09|0.17|
|[[:human_genes:C:CSTF2T|CSTF2T]]|1.97|0.48|
|[[:human_genes:S:SLC4A4|SLC4A4]]|1.98|0.48|
|[[:human_genes:L:LOC643669|LOC643669]]|1.98|0.59|
|[[:human_genes:A:AGO4|AGO4]]|1.99|0.48|
|[[:human_genes:N:NXF3|NXF3]]|2.01|0.48|
|[[:human_genes:C:CENPQ|CENPQ]]|2.01|0.48|
|[[:human_genes:E:EIF3E|EIF3E]]|2.01|0.58|
|[[:human_genes:R:RSRC1|RSRC1]]|2.01|0.58|
|[[:human_genes:G:GSX1|GSX1]]|2.03|0.55|
|[[:human_genes:P:PSMA3|PSMA3]]|2.06|0.56|
|[[:human_genes:G:GLTSCR2|GLTSCR2]]|2.06|0.59|
|[[:human_genes:M:MDN1|MDN1]]|2.07|0.59|
|[[:human_genes:P:PLK4|PLK4]]|2.15|0.58|
|[[:human_genes:S:SLC25A32|SLC25A32]]|2.16|0.48|
|[[:human_genes:P:PSMC2|PSMC2]]|2.20|0.56|
|[[:human_genes:X:XCR1|XCR1]]|2.20|0.31|
|[[:human_genes:N:NMT1|NMT1]]|2.21|0.45|
|[[:human_genes:P:PKD1L3|PKD1L3]]|2.25|0.31|
|[[:human_genes:H:HNRNPCL1|HNRNPCL1]]|2.25|0.48|
|[[:human_genes:P:PRAMEF26|PRAMEF26]]|2.28|0.73|
|[[:human_genes:P:PRAMEF25|PRAMEF25]]|2.29|0.73|
|[[:human_genes:N:NUP62CL|NUP62CL]]|2.29|0.31|
|[[:human_genes:C:CERS4|CERS4]]|2.30|0.31|
|[[:human_genes:S:SLC2A1|SLC2A1]]|2.30|0.31|
|[[:human_genes:P:POLR3GL|POLR3GL]]|2.33|0.48|
|[[:human_genes:M:MUC15|MUC15]]|2.37|0.31|
|[[:human_genes:P:PCDHB1|PCDHB1]]|2.49|0.31|
|[[:human_genes:F:FABP5|FABP5]]|2.51|0.69|
|[[:human_genes:M:MPHOSPH10|MPHOSPH10]]|2.94|0.31|
|[[:human_genes:D:DONSON|DONSON]]|3.02|0.31|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|0.079|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|0.071|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|0.067|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|0.066|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|0.061|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|0.061|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp131|L-74142 5μM R03 exp131]]|0.054|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|0.053|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|0.062|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp169|BH1 1μM R04 exp169]]|0.061|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|0.061|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp461|BS-181 20μM R08 exp461]]|0.053|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp483|FTY720 3μM R08 exp483]]|0.052|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp453|B02 10μM R08 exp453]]|0.051|<button type="primary" size="small" modal="14">View</button>|
</modal>


<modal id="1" size="lg" title="IU1-47 25μM R04 exp182  vs  Thioridazine 5μM R08 exp530">
{{:chemogenomics:comparison_plots:exp182_vs_exp530.png?nolink |}}
</modal>

<modal id="2" size="lg" title="IU1-47 25μM R04 exp182  vs  SGC0946 7μM R03 exp151">
{{:chemogenomics:comparison_plots:exp151_vs_exp182.png?nolink |}}
</modal>

<modal id="3" size="lg" title="IU1-47 25μM R04 exp182  vs  Wiskostatin 3μM R07 exp422">
{{:chemogenomics:comparison_plots:exp182_vs_exp422.png?nolink |}}
</modal>

<modal id="4" size="lg" title="IU1-47 25μM R04 exp182  vs  NN-Dimethylsphingosine 2.5μM R08 exp508">
{{:chemogenomics:comparison_plots:exp182_vs_exp508.png?nolink |}}
</modal>

<modal id="5" size="lg" title="IU1-47 25μM R04 exp182  vs  ZLN024 50μM R08 exp538">
{{:chemogenomics:comparison_plots:exp182_vs_exp538.png?nolink |}}
</modal>

<modal id="6" size="lg" title="IU1-47 25μM R04 exp182  vs  Q15 1 to 2μM on day4 R04 exp164">
{{:chemogenomics:comparison_plots:exp164_vs_exp182.png?nolink |}}
</modal>

<modal id="7" size="lg" title="IU1-47 25μM R04 exp182  vs  L-74142 5μM R03 exp131">
{{:chemogenomics:comparison_plots:exp131_vs_exp182.png?nolink |}}
</modal>

<modal id="8" size="lg" title="IU1-47 25μM R04 exp182  vs  Ibrutinib 10μM R08 exp442">
{{:chemogenomics:comparison_plots:exp182_vs_exp442.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Chlorpromazine 10μM R07 exp344  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp344.png?nolink |}}
</modal>

<modal id="10" size="lg" title="BH1 1μM R04 exp169  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp169_vs_exp182.png?nolink |}}
</modal>

<modal id="11" size="lg" title="CAY10603 0.55μM R08 exp467  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp467.png?nolink |}}
</modal>

<modal id="12" size="lg" title="BS-181 20μM R08 exp461  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp461.png?nolink |}}
</modal>

<modal id="13" size="lg" title="FTY720 3μM R08 exp483  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp483.png?nolink |}}
</modal>

<modal id="14" size="lg" title="B02 10μM R08 exp453  vs  IU1-47 25μM R04 exp182">
{{:chemogenomics:comparison_plots:exp182_vs_exp453.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">No GO term hits below threshold. (FDR <0.05)</modal>