====== Etoposide 0.3μM R05 exp199 ======
==== Mechanism of Action ====
Binds DNA-TopII complex, blocks re-ligation, induces strand breaks, semi-synthetic derivative of podophyllotoxin
  * **<color #00a2e8>Class / Subclass 1:</color>** DNA Damage, Repair and Replication / Topoisomerase II Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Etoposide%%
    * **<color #00a2e8>Synonyms:</color>** VP-16; VP-16-213
    * **<color #00a2e8>CAS #:</color>** 33419-42-0
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/36462|36462]]
    * **<color #00a2e8>IUPAC:</color>** %%(5S,5aR,8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** VJJPUSNTGOMMGY-MRVIYFEKSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 588.6
    * **<color #00a2e8>Canonical SMILES:</color>** CC1OCC2C(O1)C(C(C(O2)OC3C4COC(=O)C4C(C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
    * **<color #00a2e8>Molecular Formula:</color>** C29H32O13
{{:chemogenomics:structures:chem-0011.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** E1383
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+H)+ Calcd for C29H32O13 589.19157; found 589.19262
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** Etoposide
    * **<color #00a2e8>Min:</color>** -33.3567; **<color #00a2e8>Max:</color>** 88.0314
{{:chemogenomics:dose_response:dr_265.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.1877    |
| IC30  |0.2644    |
| IC40  |0.3501    |
| IC50  |0.4531    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 300nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 0.4
    * **<color #00a2e8>Numbers of reads</color>**: 19028764


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|0/52|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/Etoposide_0.3uM_Round-5_exp199.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='Etoposide 0.3μM R05 exp199'>
{{:chemogenomics:cranks_plots:exp199.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:Z:ZFAND5|ZFAND5]]|-2.64|0.17|
|[[:human_genes:P:PSMA3|PSMA3]]|-2.63|0.22|
|[[:human_genes:M:MAP3K7|MAP3K7]]|-2.60|0.22|
|[[:human_genes:C:CHMP2A|CHMP2A]]|-2.56|0.38|
|[[:human_genes:U:UPF2|UPF2]]|-2.55|0.24|
|[[:human_genes:A:ATP6V1D|ATP6V1D]]|-2.45|0.22|
|[[:human_genes:C:CEP192|CEP192]]|-2.42|0.32|
|[[:human_genes:A:ATP6V0B|ATP6V0B]]|-2.42|0.24|
|[[:human_genes:S:SMG7|SMG7]]|-2.42|0.24|
|[[:human_genes:H:HMG20B|HMG20B]]|-2.40|0.22|
|[[:human_genes:C:CHMP4B|CHMP4B]]|-2.39|0.22|
|[[:human_genes:Z:ZNF451|ZNF451]]|-2.36|0.22|
|[[:human_genes:I:INO80E|INO80E]]|-2.30|0.24|
|[[:human_genes:M:MTCH2|MTCH2]]|-2.28|0.24|
|[[:human_genes:O:OSBP|OSBP]]|-2.28|0.24|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.26|0.22|
|[[:human_genes:P:PAN2|PAN2]]|-2.24|0.22|
|[[:human_genes:C:CHMP6|CHMP6]]|-2.23|0.24|
|[[:human_genes:P:PSMC6|PSMC6]]|-2.17|0.59|
|[[:human_genes:M:MCM7|MCM7]]|-2.16|0.38|
|[[:human_genes:P:POLR1A|POLR1A]]|-2.16|0.48|
|[[:human_genes:S:SUPT6H|SUPT6H]]|-2.14|0.42|
|[[:human_genes:M:MR1|MR1]]|-2.12|0.24|
|[[:human_genes:P:PSMB4|PSMB4]]|-2.12|0.32|
|[[:human_genes:B:BRAP|BRAP]]|-2.11|0.32|
|[[:human_genes:W:WDR53|WDR53]]|-2.11|0.32|
|[[:human_genes:F:FAM72C|FAM72C]]|-2.11|0.68|
|[[:human_genes:C:CDT1|CDT1]]|-2.10|0.61|
|[[:human_genes:F:FAM21A|FAM21A]]|-2.10|0.24|
|[[:human_genes:S:SRGAP2C|SRGAP2C]]|-2.09|0.68|
|[[:human_genes:A:ABCF1|ABCF1]]|2.68|0.01|
|[[:human_genes:B:BTF3|BTF3]]|2.68|0.01|
|[[:human_genes:P:PHB|PHB]]|2.70|0.18|
|[[:human_genes:T:TP53|TP53]]|2.71|0.01|
|[[:human_genes:W:WDR24|WDR24]]|2.74|<0.01|
|[[:human_genes:E:EIF4G1|EIF4G1]]|2.78|<0.01|
|[[:human_genes:W:WDR59|WDR59]]|2.83|<0.01|
|[[:human_genes:S:SERF2|SERF2]]|2.86|<0.01|
|[[:human_genes:D:DIABLO|DIABLO]]|2.90|<0.01|
|[[:human_genes:E:ENY2|ENY2]]|3.05|<0.01|
|[[:human_genes:C:CASP9|CASP9]]|3.09|<0.01|
|[[:human_genes:R:RBM26|RBM26]]|3.10|<0.01|
|[[:human_genes:P:PELO|PELO]]|3.10|<0.01|
|[[:human_genes:W:WDR82|WDR82]]|3.14|<0.01|
|[[:human_genes:V:VHL|VHL]]|3.21|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|3.49|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|3.63|<0.01|
|[[:human_genes:M:MED16|MED16]]|3.66|<0.01|
|[[:human_genes:R:RPTOR|RPTOR]]|3.68|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|3.88|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|3.88|<0.01|
|[[:human_genes:C:COPS7B|COPS7B]]|4.03|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|4.07|<0.01|
|[[:human_genes:N:NAA15|NAA15]]|4.10|<0.01|
|[[:human_genes:U:UBQLN1|UBQLN1]]|4.33|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|4.83|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|5.42|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|5.85|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|6.92|<0.01|
|[[:human_genes:T:TOP2A|TOP2A]]|8.37|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.177|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.127|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.126|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.122|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.116|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.103|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.099|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.092|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.089|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.088|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.086|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|0.081|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.079|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.075|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.074|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.072|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.07|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.068|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.068|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|0.067|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|0.065|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|0.055|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.055|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|0.054|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.052|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.052|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|0.052|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.051|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.198|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|0.164|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.162|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.15|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.148|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.109|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.101|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.101|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.096|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.085|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.077|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.072|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.068|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.068|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.066|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.063|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|0.061|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.061|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.058|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.056|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.055|<button type="primary" size="small" modal="49">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.055|<button type="primary" size="small" modal="50">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.054|<button type="primary" size="small" modal="51">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.052|<button type="primary" size="small" modal="52">View</button>|
</modal>


<modal id="1" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp199.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp199_vs_exp503.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp199_vs_exp28.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Etoposide 0.3μM R05 exp199  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp199.png?nolink |}}
</modal>

<modal id="5" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp199_vs_exp34.png?nolink |}}
</modal>

<modal id="6" size="lg" title="Etoposide 0.3μM R05 exp199  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp199_vs_exp531.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Etoposide 0.3μM R05 exp199  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp199_vs_exp80.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Etoposide 0.3μM R05 exp199  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp199_vs_exp443.png?nolink |}}
</modal>

<modal id="9" size="lg" title="Etoposide 0.3μM R05 exp199  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp199_vs_exp515.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp199_vs_exp524.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp199_vs_exp527.png?nolink |}}
</modal>

<modal id="12" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Pyridostatin 4μM R05 exp240">
{{:chemogenomics:comparison_plots:exp199_vs_exp240.png?nolink |}}
</modal>

<modal id="13" size="lg" title="Etoposide 0.3μM R05 exp199  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp199_vs_exp485.png?nolink |}}
</modal>

<modal id="14" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp199_vs_exp512.png?nolink |}}
</modal>

<modal id="15" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp199_vs_exp488.png?nolink |}}
</modal>

<modal id="16" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp199_vs_exp489.png?nolink |}}
</modal>

<modal id="17" size="lg" title="Etoposide 0.3μM R05 exp199  vs  MLN-4924 2μM R00 exp22">
{{:chemogenomics:comparison_plots:exp199_vs_exp22.png?nolink |}}
</modal>

<modal id="18" size="lg" title="Etoposide 0.3μM R05 exp199  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp199.png?nolink |}}
</modal>

<modal id="19" size="lg" title="Etoposide 0.3μM R05 exp199  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp199_vs_exp85.png?nolink |}}
</modal>

<modal id="20" size="lg" title="Etoposide 0.3μM R05 exp199  vs  GSK-J4 1.5μM R08 exp441">
{{:chemogenomics:comparison_plots:exp199_vs_exp441.png?nolink |}}
</modal>

<modal id="21" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Vinblastine 0.2μM R03 exp108">
{{:chemogenomics:comparison_plots:exp108_vs_exp199.png?nolink |}}
</modal>

<modal id="22" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Tozasertib 0.1μM R07 exp414">
{{:chemogenomics:comparison_plots:exp199_vs_exp414.png?nolink |}}
</modal>

<modal id="23" size="lg" title="Etoposide 0.3μM R05 exp199  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp199_vs_exp21.png?nolink |}}
</modal>

<modal id="24" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Latrunculin-B 10μM R07 exp374">
{{:chemogenomics:comparison_plots:exp199_vs_exp374.png?nolink |}}
</modal>

<modal id="25" size="lg" title="Etoposide 0.3μM R05 exp199  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp199_vs_exp435.png?nolink |}}
</modal>

<modal id="26" size="lg" title="Etoposide 0.3μM R05 exp199  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp199.png?nolink |}}
</modal>

<modal id="27" size="lg" title="Etoposide 0.3μM R05 exp199  vs  Oligomycin-A 20μM R00 exp26">
{{:chemogenomics:comparison_plots:exp199_vs_exp26.png?nolink |}}
</modal>

<modal id="28" size="lg" title="Etoposide 0.3μM R05 exp199  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp199.png?nolink |}}
</modal>

<modal id="29" size="lg" title="Doxorubicin 0.02μM R08 exp478  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp478.png?nolink |}}
</modal>

<modal id="30" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp2.png?nolink |}}
</modal>

<modal id="31" size="lg" title="Benzoate 20000μM R08 exp456  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp456.png?nolink |}}
</modal>

<modal id="32" size="lg" title="Bleomycin 5μM R08 exp459  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="33" size="lg" title="Actinomycin-D 0.001μM R00 exp3  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="34" size="lg" title="6-Thio-2-deoxyguanosine 2μM R06 exp259  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="35" size="lg" title="Atovaquone 15μM R08 exp451  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="36" size="lg" title="AICAR 240μM R05 exp211  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="37" size="lg" title="CI-1040 9.5μM R08 exp472  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="38" size="lg" title="Aphidicolin 0.4μM R08 exp440  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp440.png?nolink |}}
</modal>

<modal id="39" size="lg" title="Dinaciclib 0.007μM R07 exp355  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp355.png?nolink |}}
</modal>

<modal id="40" size="lg" title="Dorsomorphin 5μM R07 exp357  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="41" size="lg" title="Deferoxamine 11μM R07 exp350  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="42" size="lg" title="CR131-b 0.005μM R08 exp474  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp474.png?nolink |}}
</modal>

<modal id="43" size="lg" title="BI-2536 0.02μM R03 exp96  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="44" size="lg" title="Ammonium tetrathiomolybdate 10μM R08 exp448  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="45" size="lg" title="BI-6727 0.04μM R03 exp98  vs  Etoposide 0.3μM R05 exp199">
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</modal>

<modal id="46" size="lg" title="AICAR 240μM R03 exp116  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp116_vs_exp199.png?nolink |}}
</modal>

<modal id="47" size="lg" title="Bortezomib 0.05μM R00 exp7  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp7.png?nolink |}}
</modal>

<modal id="48" size="lg" title="Artemisinin 50μM R08 exp450  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp450.png?nolink |}}
</modal>

<modal id="49" size="lg" title="42°C R08 exp539  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp539.png?nolink |}}
</modal>

<modal id="50" size="lg" title="CB-5083 0.4μM R08 exp468  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp468.png?nolink |}}
</modal>

<modal id="51" size="lg" title="DABN 20μM R00 exp17  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp17_vs_exp199.png?nolink |}}
</modal>

<modal id="52" size="lg" title="Centrinone 0.5μM R07 exp343  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp343.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|ESCRT III complex|204.57|CHMP2A,CHMP4B,CHMP6|
|vesicle fusion with vacuole|184.11|CHMP2A,CHMP4B,CHMP6|
|multivesicular body-lysosome fusion|184.11|CHMP2A,CHMP4B,CHMP6|
|vacuole fusion|167.37|CHMP2A,CHMP4B,CHMP6|
|amphisome|153.43|CHMP2A,CHMP4B,CHMP6|
|viral budding from plasma membrane|153.43|CHMP2A,CHMP4B,CHMP6|
|non-lytic viral release|141.62|CHMP2A,CHMP4B,CHMP6|
|midbody abscission|115.07|CHMP2A,CHMP4B,CHMP6|
|endosome to lysosome transport via multivesicular body sorting pathway|115.07|CHMP2A,CHMP4B,CHMP6|
|late endosome to lysosome transport|108.30|CHMP2A,CHMP4B,CHMP6|
|regulation of mitotic spindle assembly|87.67|CHMP2A,CHMP4B,CHMP6|
|mitotic metaphase chromosome alignment|48.13|CHMP2A,CHMP4B,CHMP6,CDT1|
|endosome organization|34.87|CHMP2A,ATP6V1D,ATP6V0B,CHMP4B,CHMP6|
|lytic vacuole organization|31.96|CHMP2A,ATP6V1D,ATP6V0B,CHMP4B,CHMP6|
|lysosome organization|31.96|CHMP2A,ATP6V1D,ATP6V0B,CHMP4B,CHMP6|
|mitotic sister chromatid segregation|22.56|CHMP2A,CEP192,CHMP4B,CHMP6,CDT1|
|sister chromatid segregation|21.92|CHMP2A,CEP192,CHMP4B,CHMP6,CDT1|
|endosome membrane|9.03|MAP3K7,CHMP2A,ATP6V1D,ATP6V0B,CHMP4B,CHMP6,MR1,WASHC2A|
|macromolecule catabolic process|6.67|PSMA3,CHMP2A,UPF2,SMG7,CHMP4B,CNOT2,PAN2,CHMP6,PSMC6,PSMB4|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.33|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|441.87|APAF1,CYCS,CASP9,DIABLO|
|glial cell apoptotic process|276.17|CASP9,TP53|
|GATOR2 complex|276.17|WDR59,WDR24|
|positive regulation of mitochondrial membrane permeability|59.18|BAK1,VDAC2,TP53|
|positive regulation of membrane permeability|53.45|BAK1,VDAC2,TP53|
|negative regulation of autophagy|25.11|RPTOR,VHL,EIF4G1,TP53|
|positive regulation of cysteine-type endopeptidase activity|22.27|APAF1,BAK1,CYCS,CASP9,DIABLO|
|intrinsic apoptotic signaling pathway|20.71|APAF1,BAK1,CYCS,CASP9,DIABLO,TP53|
|positive regulation of endopeptidase activity|19.05|APAF1,BAK1,CYCS,CASP9,DIABLO|
|positive regulation of peptidase activity|17.37|APAF1,BAK1,CYCS,CASP9,DIABLO|
|response to endoplasmic reticulum stress|14.93|APAF1,BAK1,UBQLN1,FAF2,EIF4G1,TP53|
|regulation of cysteine-type endopeptidase activity|14.69|APAF1,BAK1,CYCS,CASP9,DIABLO|
|apoptotic signaling pathway|12.55|APAF1,BAK1,VDAC2,CYCS,CASP9,DIABLO,TP53|
|response to hypoxia|12.37|APAF1,UBQLN1,RPTOR,VHL,CASP9,TP53|
|response to decreased oxygen levels|11.63|APAF1,UBQLN1,RPTOR,VHL,CASP9,TP53|
|response to oxygen levels|10.66|APAF1,UBQLN1,RPTOR,VHL,CASP9,TP53|
|cellular response to external stimulus|10.20|BAK1,RPTOR,WDR59,EIF4G1,WDR24,TP53|
|positive regulation of proteolysis|9.83|APAF1,BAK1,UBQLN1,CYCS,CASP9,DIABLO|
</modal>