====== 5-Fluorouracil 20μM R00 exp2 ======
==== Mechanism of Action ====
Thymidylate synthase inhibitor, blocks DNA replication
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Antimetabolite
  * **<color #00a2e8>Class / Subclass 2:</color>** DNA Damage, Repair and Replication / Replication Inhibitor



==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%5-Fluorouracil%%
    * **<color #00a2e8>Synonyms:</color>** 5-FU
    * **<color #00a2e8>CAS #:</color>** 51-21-8
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/3385|3385]]
    * **<color #00a2e8>IUPAC:</color>** %%5-fluoro-1H-pyrimidine-2,4-dione%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
    * **<color #00a2e8>INCHI Key:</color>** GHASVSINZRGABV-UHFFFAOYSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 130.08
    * **<color #00a2e8>Canonical SMILES:</color>** C1=C(C(=O)NC(=O)N1)F
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C4H3FN2O2
{{:chemogenomics:structures:chem-0001.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Sigma-Aldrich
    * **<color #00a2e8>Catalog #:</color>** F6627
    * **<color #00a2e8>Lot #:</color>** 102K0970
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>LCMS:</color>** Tr 0.14 min, m/z 129- [M-H]-
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** 5-FU
    * **<color #00a2e8>Min:</color>** -8.9515; **<color #00a2e8>Max:</color>** 61.1847
{{:chemogenomics:dose_response:dr_253.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |12.7820    |
| IC30  |22.9250    |
| IC40  |37.0071    |
| IC50  |57.4305    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 00
    * **<color #00a2e8>Dose</color>**: 20µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 1.5
    * **<color #00a2e8>Numbers of reads</color>**: 11051144


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|8/86|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/5-Fluorouracil_20uM_Round-0_exp2.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="default" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='5-Fluorouracil 20μM R00 exp2'>
{{:chemogenomics:cranks_plots:exp2.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:P:POLA1|POLA1]]|-3.74|0.11|
|[[:human_genes:B:BRD2|BRD2]]|-3.32|<0.01|
|[[:human_genes:G:GOLGA6L1|GOLGA6L1]]|-3.06|0.17|
|[[:human_genes:A:ATP6V1A|ATP6V1A]]|-3.02|0.02|
|[[:human_genes:S:SF3A1|SF3A1]]|-2.93|0.32|
|[[:human_genes:S:SEPHS2|SEPHS2]]|-2.75|0.03|
|[[:human_genes:V:VPS25|VPS25]]|-2.71|0.18|
|[[:human_genes:P:PDS5B|PDS5B]]|-2.68|0.03|
|[[:human_genes:B:BCOR|BCOR]]|-2.68|0.05|
|[[:human_genes:R:RRM2|RRM2]]|-2.67|0.38|
|[[:human_genes:P:PCGF1|PCGF1]]|-2.66|0.03|
|[[:human_genes:C:CNOT2|CNOT2]]|-2.64|0.03|
|[[:human_genes:P:PAN2|PAN2]]|-2.57|0.07|
|[[:human_genes:M:MGA|MGA]]|-2.54|0.05|
|[[:human_genes:A:ATXN2L|ATXN2L]]|-2.50|0.08|
|[[:human_genes:P:POLR2I|POLR2I]]|-2.46|0.05|
|[[:human_genes:S:SPRR2D|SPRR2D]]|-2.43|0.09|
|[[:human_genes:D:DDX3X|DDX3X]]|-2.40|0.07|
|[[:human_genes:N:NPIPB8|NPIPB8]]|-2.39|0.38|
|[[:human_genes:I:INO80E|INO80E]]|-2.37|0.11|
|[[:human_genes:P:POLR2A|POLR2A]]|-2.31|0.32|
|[[:human_genes:G:GCGR|GCGR]]|-2.29|0.09|
|[[:human_genes:P:PRPH|PRPH]]|-2.29|0.09|
|[[:human_genes:M:MSI2|MSI2]]|-2.26|0.10|
|[[:human_genes:A:ATP6V1B2|ATP6V1B2]]|-2.25|0.16|
|[[:human_genes:C:CHMP4B|CHMP4B]]|-2.24|0.11|
|[[:human_genes:F:FOXD1|FOXD1]]|-2.24|0.28|
|[[:human_genes:N:NPRL3|NPRL3]]|-2.23|0.23|
|[[:human_genes:P:POLA2|POLA2]]|-2.22|0.36|
|[[:human_genes:S:SAE1|SAE1]]|-2.22|0.24|
|[[:human_genes:M:MIOS|MIOS]]|3.28|<0.01|
|[[:human_genes:I:ID3|ID3]]|3.28|<0.01|
|[[:human_genes:C:CDKN1A|CDKN1A]]|3.28|<0.01|
|[[:human_genes:C:CSNK2B|CSNK2B]]|3.32|<0.01|
|[[:human_genes:W:WDR5|WDR5]]|3.40|<0.01|
|[[:human_genes:A:AURKB|AURKB]]|3.53|<0.01|
|[[:human_genes:U:UBE2G1|UBE2G1]]|3.54|<0.01|
|[[:human_genes:S:SUV420H1|SUV420H1]]|3.63|<0.01|
|[[:human_genes:F:FBXO11|FBXO11]]|3.67|<0.01|
|[[:human_genes:M:MEAF6|MEAF6]]|3.67|<0.01|
|[[:human_genes:G:GMPPB|GMPPB]]|3.76|<0.01|
|[[:human_genes:D:DIABLO|DIABLO]]|3.84|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|3.87|<0.01|
|[[:human_genes:U:UBE2K|UBE2K]]|4.01|<0.01|
|[[:human_genes:T:TLE4|TLE4]]|4.07|<0.01|
|[[:human_genes:C:CASP9|CASP9]]|4.44|<0.01|
|[[:human_genes:C:CYCS|CYCS]]|4.90|<0.01|
|[[:human_genes:R:RPL11|RPL11]]|4.93|<0.01|
|[[:human_genes:H:HCCS|HCCS]]|5.04|<0.01|
|[[:human_genes:H:HEATR3|HEATR3]]|5.16|<0.01|
|[[:human_genes:U:UBQLN1|UBQLN1]]|5.17|<0.01|
|[[:human_genes:V:VDAC2|VDAC2]]|5.29|<0.01|
|[[:human_genes:P:PLAA|PLAA]]|5.79|<0.01|
|[[:human_genes:A:APAF1|APAF1]]|6.23|<0.01|
|[[:human_genes:E:ENY2|ENY2]]|6.31|<0.01|
|[[:human_genes:X:XPO7|XPO7]]|6.32|<0.01|
|[[:human_genes:M:MARCH5|MARCH5]]|6.98|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|7.18|<0.01|
|[[:human_genes:U:UCK2|UCK2]]|7.25|<0.01|
|[[:human_genes:T:TP53|TP53]]|8.50|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|0.31|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|0.198|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|0.193|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|0.181|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|0.164|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|0.153|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|0.139|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|0.132|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|0.128|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|0.121|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|0.115|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.114|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|0.111|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|0.11|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|0.107|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|0.106|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.105|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp17|DABN 20μM R00 exp17]]|0.098|<button type="primary" size="small" modal="18">View</button>|
|[[:results:exp135|MS023 7μM R03 exp135]]|0.096|<button type="primary" size="small" modal="19">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.092|<button type="primary" size="small" modal="20">View</button>|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|0.088|<button type="primary" size="small" modal="21">View</button>|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|0.087|<button type="primary" size="small" modal="22">View</button>|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|0.086|<button type="primary" size="small" modal="23">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.086|<button type="primary" size="small" modal="24">View</button>|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|0.086|<button type="primary" size="small" modal="25">View</button>|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|0.082|<button type="primary" size="small" modal="26">View</button>|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|0.08|<button type="primary" size="small" modal="27">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.074|<button type="primary" size="small" modal="28">View</button>|
|[[:results:exp116|AICAR 240μM R03 exp116]]|0.072|<button type="primary" size="small" modal="29">View</button>|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|0.071|<button type="primary" size="small" modal="30">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.07|<button type="primary" size="small" modal="31">View</button>|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|0.068|<button type="primary" size="small" modal="32">View</button>|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|0.068|<button type="primary" size="small" modal="33">View</button>|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|0.067|<button type="primary" size="small" modal="34">View</button>|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|0.067|<button type="primary" size="small" modal="35">View</button>|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|0.061|<button type="primary" size="small" modal="36">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.059|<button type="primary" size="small" modal="37">View</button>|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|0.059|<button type="primary" size="small" modal="38">View</button>|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|0.056|<button type="primary" size="small" modal="39">View</button>|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|0.055|<button type="primary" size="small" modal="40">View</button>|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|0.055|<button type="primary" size="small" modal="41">View</button>|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|0.055|<button type="primary" size="small" modal="42">View</button>|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|0.054|<button type="primary" size="small" modal="43">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.053|<button type="primary" size="small" modal="44">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.053|<button type="primary" size="small" modal="45">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.052|<button type="primary" size="small" modal="46">View</button>|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|0.051|<button type="primary" size="small" modal="47">View</button>|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|0.051|<button type="primary" size="small" modal="48">View</button>|
|[[:results:exp539|42°C R08 exp539]]|0.091|<button type="primary" size="small" modal="49">View</button>|
</modal>


<modal id="1" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Actinomycin-D 0.001μM R00 exp3">
{{:chemogenomics:comparison_plots:exp2_vs_exp3.png?nolink |}}
</modal>

<modal id="2" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Pimelic-diphenylamide-106 5μM R00 exp28">
{{:chemogenomics:comparison_plots:exp2_vs_exp28.png?nolink |}}
</modal>

<modal id="3" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Rotenone 20μM R00 exp34">
{{:chemogenomics:comparison_plots:exp2_vs_exp34.png?nolink |}}
</modal>

<modal id="4" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Etoposide 1μM R00 exp19">
{{:chemogenomics:comparison_plots:exp19_vs_exp2.png?nolink |}}
</modal>

<modal id="5" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Etoposide 0.3μM R05 exp199">
{{:chemogenomics:comparison_plots:exp199_vs_exp2.png?nolink |}}
</modal>

<modal id="6" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Benzoate 20000μM R08 exp456">
{{:chemogenomics:comparison_plots:exp2_vs_exp456.png?nolink |}}
</modal>

<modal id="7" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Mitomycin-C 0.06μM R08 exp503">
{{:chemogenomics:comparison_plots:exp2_vs_exp503.png?nolink |}}
</modal>

<modal id="8" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  CI-1040 9.5μM R08 exp472">
{{:chemogenomics:comparison_plots:exp2_vs_exp472.png?nolink |}}
</modal>

<modal id="9" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  THZ1 0.06μM R08 exp531">
{{:chemogenomics:comparison_plots:exp2_vs_exp531.png?nolink |}}
</modal>

<modal id="10" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Doxorubicin 0.02μM R08 exp478">
{{:chemogenomics:comparison_plots:exp2_vs_exp478.png?nolink |}}
</modal>

<modal id="11" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Bleomycin 5μM R08 exp459">
{{:chemogenomics:comparison_plots:exp2_vs_exp459.png?nolink |}}
</modal>

<modal id="12" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp2_vs_exp211.png?nolink |}}
</modal>

<modal id="13" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  MLN-4924 2μM R00 exp22">
{{:chemogenomics:comparison_plots:exp2_vs_exp22.png?nolink |}}
</modal>

<modal id="14" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  RO-3307 4.7μM R02 exp80">
{{:chemogenomics:comparison_plots:exp2_vs_exp80.png?nolink |}}
</modal>

<modal id="15" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Aphidicolin 0.4μM R08 exp440">
{{:chemogenomics:comparison_plots:exp2_vs_exp440.png?nolink |}}
</modal>

<modal id="16" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  UM131593 0.2μM R03 exp106">
{{:chemogenomics:comparison_plots:exp106_vs_exp2.png?nolink |}}
</modal>

<modal id="17" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  6-Thio-2-deoxyguanosine 2μM R06 exp259">
{{:chemogenomics:comparison_plots:exp2_vs_exp259.png?nolink |}}
</modal>

<modal id="18" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  DABN 20μM R00 exp17">
{{:chemogenomics:comparison_plots:exp17_vs_exp2.png?nolink |}}
</modal>

<modal id="19" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp2.png?nolink |}}
</modal>

<modal id="20" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp2_vs_exp443.png?nolink |}}
</modal>

<modal id="21" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Bortezomib 0.05μM R00 exp7">
{{:chemogenomics:comparison_plots:exp2_vs_exp7.png?nolink |}}
</modal>

<modal id="22" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  GSK626616 14μM R08 exp485">
{{:chemogenomics:comparison_plots:exp2_vs_exp485.png?nolink |}}
</modal>

<modal id="23" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Atovaquone 15μM R08 exp451">
{{:chemogenomics:comparison_plots:exp2_vs_exp451.png?nolink |}}
</modal>

<modal id="24" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp2_vs_exp512.png?nolink |}}
</modal>

<modal id="25" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  PU-H71 1μM R08 exp515">
{{:chemogenomics:comparison_plots:exp2_vs_exp515.png?nolink |}}
</modal>

<modal id="26" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Tanespimycin 14μM R08 exp527">
{{:chemogenomics:comparison_plots:exp2_vs_exp527.png?nolink |}}
</modal>

<modal id="27" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  JQ1 0.8μM R08 exp435">
{{:chemogenomics:comparison_plots:exp2_vs_exp435.png?nolink |}}
</modal>

<modal id="28" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp2_vs_exp489.png?nolink |}}
</modal>

<modal id="29" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  AICAR 240μM R03 exp116">
{{:chemogenomics:comparison_plots:exp116_vs_exp2.png?nolink |}}
</modal>

<modal id="30" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Staurosporine 0.02μM R08 exp524">
{{:chemogenomics:comparison_plots:exp2_vs_exp524.png?nolink |}}
</modal>

<modal id="31" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp2_vs_exp488.png?nolink |}}
</modal>

<modal id="32" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Deferoxamine 11μM R07 exp350">
{{:chemogenomics:comparison_plots:exp2_vs_exp350.png?nolink |}}
</modal>

<modal id="33" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  GSK461364A 0.1μM R03 exp126">
{{:chemogenomics:comparison_plots:exp126_vs_exp2.png?nolink |}}
</modal>

<modal id="34" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Diepoxybutane 3μM R07 exp354">
{{:chemogenomics:comparison_plots:exp2_vs_exp354.png?nolink |}}
</modal>

<modal id="35" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  CR131-b 0.005μM R08 exp474">
{{:chemogenomics:comparison_plots:exp2_vs_exp474.png?nolink |}}
</modal>

<modal id="36" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Rotenone 2μM R00 exp33">
{{:chemogenomics:comparison_plots:exp2_vs_exp33.png?nolink |}}
</modal>

<modal id="37" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp2_vs_exp85.png?nolink |}}
</modal>

<modal id="38" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Ammonium tetrathiomolybdate 10μM R08 exp448">
{{:chemogenomics:comparison_plots:exp2_vs_exp448.png?nolink |}}
</modal>

<modal id="39" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Dinaciclib 0.007μM R07 exp355">
{{:chemogenomics:comparison_plots:exp2_vs_exp355.png?nolink |}}
</modal>

<modal id="40" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  LY2090314 0.003μM R08 exp500 no dilution day6">
{{:chemogenomics:comparison_plots:exp2_vs_exp500.png?nolink |}}
</modal>

<modal id="41" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Etoposide 10μM R00 exp20">
{{:chemogenomics:comparison_plots:exp2_vs_exp20.png?nolink |}}
</modal>

<modal id="42" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Centrinone 0.5μM R07 exp343">
{{:chemogenomics:comparison_plots:exp2_vs_exp343.png?nolink |}}
</modal>

<modal id="43" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Dorsomorphin 5μM R07 exp357">
{{:chemogenomics:comparison_plots:exp2_vs_exp357.png?nolink |}}
</modal>

<modal id="44" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp2_vs_exp21.png?nolink |}}
</modal>

<modal id="45" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp2.png?nolink |}}
</modal>

<modal id="46" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp2_vs_exp450.png?nolink |}}
</modal>

<modal id="47" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  BML-284 0.09μM R08 exp460">
{{:chemogenomics:comparison_plots:exp2_vs_exp460.png?nolink |}}
</modal>

<modal id="48" size="lg" title="5-Fluorouracil 20μM R00 exp2  vs  BI-2536 0.02μM R03 exp96">
{{:chemogenomics:comparison_plots:exp2_vs_exp96.png?nolink |}}
</modal>

<modal id="49" size="lg" title="42°C R08 exp539  vs  5-Fluorouracil 20μM R00 exp2">
{{:chemogenomics:comparison_plots:exp2_vs_exp539.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">No GO term hits below threshold. (FDR <0.05)</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|apoptosome|552.70|APAF1,CASP9|
|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|442.16|APAF1,CYCS,CASP9,DIABLO|
|glial cell apoptotic process|276.35|TP53,CASP9|
|positive regulation of mitochondrial membrane permeability|59.22|TP53,BAK1,VDAC2|
|cellular response to UV|31.76|TP53,BAK1,CASP9,AURKB,CDKN1A|
|intrinsic apoptotic signaling pathway in response to DNA damage|31.14|TP53,BAK1,CASP9,CDKN1A|
|cellular response to light stimulus|24.90|TP53,BAK1,CASP9,AURKB,CDKN1A|
|intrinsic apoptotic signaling pathway|24.18|TP53,BAK1,APAF1,CYCS,CASP9,DIABLO,CDKN1A|
|positive regulation of cysteine-type endopeptidase activity|22.29|BAK1,APAF1,CYCS,CASP9,DIABLO|
|positive regulation of endopeptidase activity|19.06|BAK1,APAF1,CYCS,CASP9,DIABLO|
|response to UV|18.55|TP53,BAK1,CASP9,AURKB,CDKN1A|
|positive regulation of peptidase activity|17.38|BAK1,APAF1,CYCS,CASP9,DIABLO|
|cellular response to radiation|16.55|TP53,BAK1,CASP9,AURKB,CDKN1A|
|apoptotic signaling pathway|14.36|TP53,BAK1,APAF1,VDAC2,CYCS,CASP9,DIABLO,CDKN1A|
|ubiquitin protein ligase binding|11.09|TP53,RPL11,UBE2K,FAF2,UBE2G1,CDKN1A|
|ubiquitin-like protein ligase binding|10.46|TP53,RPL11,UBE2K,FAF2,UBE2G1,CDKN1A|
|positive regulation of programmed cell death|8.70|TP53,BAK1,APAF1,RPL11,CASP9,DIABLO,CDKN1A,ID3|
|regulation of DNA metabolic process|8.69|TP53,ENY2,APAF1,MEAF6,KMT5B,AURKB,CDKN1A,ID3|
|regulation of proteolysis|8.43|TP53,BAK1,APAF1,UBQLN1,RPL11,CYCS,CASP9,UBE2K,DIABLO|
</modal>