====== 2-Deoxy-D-glucose 800μM R05 exp214 ======
==== Mechanism of Action ====
Inhibits phosphoglucoisomerase, competitive, blocks glycolysis
  * **<color #00a2e8>Class / Subclass 1:</color>** Metabolism / Metabolic Enzyme Inhibitor




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%Deoxyglucose%%
    * **<color #00a2e8>Synonyms:</color>** 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose
    * **<color #00a2e8>CAS #:</color>** 154-17-6
    * **<color #00a2e8>PubChem CID:</color>** [[https://pubchem.ncbi.nlm.nih.gov/compound/108223|108223]]
    * **<color #00a2e8>IUPAC:</color>** %%(3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal%%
    * **<color #00a2e8>INCHI Name:</color>** InChI=1S/C6H12O5/c7-2-1-4(9)6(11)5(10)3-8/h2,4-6,8-11H,1,3H2/t4-,5-,6+/m1/s1
    * **<color #00a2e8>INCHI Key:</color>** VRYALKFFQXWPIH-PBXRRBTRSA-N
    * **<color #00a2e8>Molecular Weight:</color>** 164.16
    * **<color #00a2e8>Canonical SMILES:</color>** C(C=O)C(C(C(CO)O)O)O
    * **<color #00a2e8>Isomeric SMILES:</color>** C(C=O)[C@H]([C@@H]([C@@H](CO)O)O)O
    * **<color #00a2e8>Molecular Formula:</color>** C6H12O5
{{:chemogenomics:structures:chem-0108.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** Chem-Impex International
    * **<color #00a2e8>Catalog #:</color>** 21916
    * **<color #00a2e8>Lot #:</color>** N/A
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+Na)+ Calcd for C6H12O5 187.05769; found 187.05708
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** 2-deoxy-D-glucose
    * **<color #00a2e8>Min:</color>** -9.1371; **<color #00a2e8>Max:</color>** 57.2932
{{:chemogenomics:dose_response:dr_176.png?nolink&500 |}}
\\ 
\\ 
\\ 
\\ 
|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |0.5031    |
| IC30  |0.7657    |
| IC40  |1.0805    |
| IC50  |1.4822    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 800µM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 2.3
    * **<color #00a2e8>Numbers of reads</color>**: 17052896


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|10/60|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/2-Deoxy-D-glucose_800uM_Round-5_exp214.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='2-Deoxy-D-glucose 800μM R05 exp214'>
{{:chemogenomics:cranks_plots:exp214.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:G:GDPGP1|GDPGP1]]|-4.46|<0.01|
|[[:human_genes:C:C6orf136|C6orf136]]|-3.58|<0.01|
|[[:human_genes:P:PMM2|PMM2]]|-3.40|<0.01|
|[[:human_genes:C:CCM2|CCM2]]|-3.14|<0.01|
|[[:human_genes:S:SLC25A5|SLC25A5]]|-3.01|<0.01|
|[[:human_genes:C:C17orf89|C17orf89]]|-2.86|<0.01|
|[[:human_genes:B:BCL2L1|BCL2L1]]|-2.77|0.01|
|[[:human_genes:N:NDUFB10|NDUFB10]]|-2.64|0.02|
|[[:human_genes:T:TIMM21|TIMM21]]|-2.58|0.03|
|[[:human_genes:A:ATP5B|ATP5B]]|-2.46|0.05|
|[[:human_genes:W:WAPAL|WAPAL]]|-2.43|0.16|
|[[:human_genes:U:USP5|USP5]]|-2.42|0.07|
|[[:human_genes:W:WBSCR16|WBSCR16]]|-2.41|0.16|
|[[:human_genes:O:OTUB1|OTUB1]]|-2.41|0.07|
|[[:human_genes:A:ATG9A|ATG9A]]|-2.41|0.06|
|[[:human_genes:Y:YPEL5|YPEL5]]|-2.40|0.06|
|[[:human_genes:N:NDUFAF1|NDUFAF1]]|-2.38|0.13|
|[[:human_genes:R:RHOA|RHOA]]|-2.37|0.06|
|[[:human_genes:G:G6PD|G6PD]]|-2.37|0.06|
|[[:human_genes:M:MRPL55|MRPL55]]|-2.36|0.06|
|[[:human_genes:T:TNPO1|TNPO1]]|-2.34|0.06|
|[[:human_genes:V:VPS25|VPS25]]|-2.31|0.40|
|[[:human_genes:C:CHMP7|CHMP7]]|-2.31|0.07|
|[[:human_genes:E:EEF2|EEF2]]|-2.30|0.40|
|[[:human_genes:A:ATP1B4|ATP1B4]]|-2.30|0.11|
|[[:human_genes:N:NR2C2|NR2C2]]|-2.28|0.07|
|[[:human_genes:A:ATP5E|ATP5E]]|-2.26|0.21|
|[[:human_genes:H:HSP90B1|HSP90B1]]|-2.26|0.07|
|[[:human_genes:S:SCO2|SCO2]]|-2.25|0.07|
|[[:human_genes:P:PDHB|PDHB]]|-2.25|0.07|
|[[:human_genes:C:CTU2|CTU2]]|2.81|<0.01|
|[[:human_genes:E:EIF4A1|EIF4A1]]|2.84|<0.01|
|[[:human_genes:B:BAK1|BAK1]]|2.86|<0.01|
|[[:human_genes:R:RPS25|RPS25]]|2.89|<0.01|
|[[:human_genes:M:MAGT1|MAGT1]]|2.91|<0.01|
|[[:human_genes:F:FAF2|FAF2]]|2.91|<0.01|
|[[:human_genes:A:ARID4B|ARID4B]]|2.91|<0.01|
|[[:human_genes:I:IMPDH2|IMPDH2]]|2.97|<0.01|
|[[:human_genes:S:SP2|SP2]]|3.03|<0.01|
|[[:human_genes:A:ACO2|ACO2]]|3.13|<0.01|
|[[:human_genes:S:SLC4A7|SLC4A7]]|3.15|<0.01|
|[[:human_genes:Z:ZCCHC8|ZCCHC8]]|3.16|<0.01|
|[[:human_genes:A:ATIC|ATIC]]|3.18|<0.01|
|[[:human_genes:A:AK6|AK6]]|3.22|<0.01|
|[[:human_genes:H:HINT1|HINT1]]|3.29|<0.01|
|[[:human_genes:M:MOCS3|MOCS3]]|3.46|<0.01|
|[[:human_genes:T:TKT|TKT]]|3.48|<0.01|
|[[:human_genes:P:PGM2L1|PGM2L1]]|3.59|<0.01|
|[[:human_genes:I:IDH1|IDH1]]|3.59|<0.01|
|[[:human_genes:P:PGLS|PGLS]]|3.71|<0.01|
|[[:human_genes:A:AHCYL1|AHCYL1]]|3.73|<0.01|
|[[:human_genes:S:SLC2A1|SLC2A1]]|3.79|<0.01|
|[[:human_genes:A:ATXN2L|ATXN2L]]|4.10|<0.01|
|[[:human_genes:S:STT3B|STT3B]]|4.35|<0.01|
|[[:human_genes:T:TARDBP|TARDBP]]|5.04|<0.01|
|[[:human_genes:M:MLXIP|MLXIP]]|6.25|<0.01|
|[[:human_genes:H:HK2|HK2]]|6.40|<0.01|
|[[:human_genes:P:PFKP|PFKP]]|7.65|<0.01|
|[[:human_genes:T:TXNIP|TXNIP]]|8.44|<0.01|
|[[:human_genes:M:MLX|MLX]]|8.49|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp135|MS023 7μM R03 exp135]]|0.082|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp134|MS023 2μM R03 exp134]]|0.08|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|0.067|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|0.065|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|0.063|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|0.061|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|0.06|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|0.058|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|0.057|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|0.056|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|0.055|<button type="primary" size="small" modal="11">View</button>|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|0.055|<button type="primary" size="small" modal="12">View</button>|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|0.054|<button type="primary" size="small" modal="13">View</button>|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|0.054|<button type="primary" size="small" modal="14">View</button>|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|0.053|<button type="primary" size="small" modal="15">View</button>|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|0.053|<button type="primary" size="small" modal="16">View</button>|
|[[:results:exp211|AICAR 240μM R05 exp211]]|0.051|<button type="primary" size="small" modal="17">View</button>|
|[[:results:exp359|FK-506 30μM R07 exp359]]|0.051|<button type="primary" size="small" modal="18">View</button>|
</modal>


<modal id="1" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  MS023 7μM R03 exp135">
{{:chemogenomics:comparison_plots:exp135_vs_exp214.png?nolink |}}
</modal>

<modal id="2" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  MS023 2μM R03 exp134">
{{:chemogenomics:comparison_plots:exp134_vs_exp214.png?nolink |}}
</modal>

<modal id="3" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Ethanol 0.01 R05 exp234">
{{:chemogenomics:comparison_plots:exp214_vs_exp234.png?nolink |}}
</modal>

<modal id="4" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Olaparib 4μM R08 exp512">
{{:chemogenomics:comparison_plots:exp214_vs_exp512.png?nolink |}}
</modal>

<modal id="5" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  UM0129480 7μM R02 exp85">
{{:chemogenomics:comparison_plots:exp214_vs_exp85.png?nolink |}}
</modal>

<modal id="6" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Artemisinin 50μM R08 exp450">
{{:chemogenomics:comparison_plots:exp214_vs_exp450.png?nolink |}}
</modal>

<modal id="7" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Milciclib 2μM R08 exp502">
{{:chemogenomics:comparison_plots:exp214_vs_exp502.png?nolink |}}
</modal>

<modal id="8" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  6-Thio-2-deoxyguanosine 2μM R06 exp259">
{{:chemogenomics:comparison_plots:exp214_vs_exp259.png?nolink |}}
</modal>

<modal id="9" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Hippuristanol 0.12μM R08 exp488">
{{:chemogenomics:comparison_plots:exp214_vs_exp488.png?nolink |}}
</modal>

<modal id="10" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  CB-5083 0.4μM R08 exp468">
{{:chemogenomics:comparison_plots:exp214_vs_exp468.png?nolink |}}
</modal>

<modal id="11" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Cytochalasin-B 5μM R07 exp349">
{{:chemogenomics:comparison_plots:exp214_vs_exp349.png?nolink |}}
</modal>

<modal id="12" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Thapsigargin 0.005μM R07 exp407">
{{:chemogenomics:comparison_plots:exp214_vs_exp407.png?nolink |}}
</modal>

<modal id="13" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  Hippuristanol 0.12μM R08 exp489 no dilution day6">
{{:chemogenomics:comparison_plots:exp214_vs_exp489.png?nolink |}}
</modal>

<modal id="14" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  ML-792 0.2μM R08 exp505">
{{:chemogenomics:comparison_plots:exp214_vs_exp505.png?nolink |}}
</modal>

<modal id="15" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  MLN-4924 0.2μM R00 exp21">
{{:chemogenomics:comparison_plots:exp21_vs_exp214.png?nolink |}}
</modal>

<modal id="16" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  SNS-032 15μM R08 exp443">
{{:chemogenomics:comparison_plots:exp214_vs_exp443.png?nolink |}}
</modal>

<modal id="17" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  AICAR 240μM R05 exp211">
{{:chemogenomics:comparison_plots:exp211_vs_exp214.png?nolink |}}
</modal>

<modal id="18" size="lg" title="2-Deoxy-D-glucose 800μM R05 exp214  vs  FK-506 30μM R07 exp359">
{{:chemogenomics:comparison_plots:exp214_vs_exp359.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)|306.85|ATP5F1B,ATP5F1E|
|proton-transporting ATP synthase complex, catalytic core F(1)|245.48|ATP5F1B,ATP5F1E|
|mitochondrial respiratory chain complex assembly|28.22|NDUFB10,TIMM21,NDUFAF1,SCO2|
|oxidative phosphorylation|24.80|NDUFB10,ATP5F1B,NDUFAF1,ATP5F1E|
|inner mitochondrial membrane protein complex|23.25|NDUFB10,TIMM21,ATP5F1B,NDUFAF1,ATP5F1E|
|cellular respiration|18.16|NDUFB10,ATP5F1B,NDUFAF1,ATP5F1E,SCO2|
|mitochondrial protein-containing complex|15.68|SLC25A5,NDUFB10,TIMM21,ATP5F1B,NDUFAF1,MRPL55,ATP5F1E|
|mitochondrial inner membrane|13.40|SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,NDUFAF1,MRPL55,ATP5F1E,SCO2|
|organelle inner membrane|13.24|SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,NDUFAF1,MRPL55,ATP1B4,ATP5F1E,SCO2|
|energy derivation by oxidation of organic compounds|13.11|NDUFB10,ATP5F1B,NDUFAF1,ATP5F1E,SCO2|
|mitochondrion organization|11.69|SLC25A5,BCL2L1,NDUFB10,TIMM21,RCC1L,ATG9A,NDUFAF1,SCO2|
|generation of precursor metabolites and energy|9.79|NDUFB10,ATP5F1B,NDUFAF1,G6PD,ATP5F1E,SCO2|
|mitochondrial membrane|9.58|SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,ATG9A,NDUFAF1,MRPL55,ATP5F1E,SCO2|
|mitochondrial matrix|9.06|SLC25A5,BCL2L1,ATP5F1B,NDUFAF1,MRPL55,ATP5F1E,SCO2|
|mitochondrial envelope|8.99|SLC25A5,BCL2L1,NDUFB10,TIMM21,ATP5F1B,RCC1L,ATG9A,NDUFAF1,MRPL55,ATP5F1E,SCO2|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|tRNA wobble position uridine thiolation|368.22|MOCS3,CTU2|
|tRNA thio-modification|276.17|MOCS3,CTU2|
|isocitrate metabolic process|220.93|IDH1,ACO2|
|glucose 6-phosphate metabolic process|82.85|HK2,PGLS,TKT|
|purine nucleotide metabolic process|9.69|PGLS,IDH1,TKT,HINT1,ATIC,SLC4A7,IMPDH2|
|nucleotide metabolic process|9.65|PGLS,IDH1,TKT,HINT1,AK6,ATIC,SLC4A7,IMPDH2|
|nucleoside phosphate metabolic process|9.46|PGLS,IDH1,TKT,HINT1,AK6,ATIC,SLC4A7,IMPDH2|
|purine-containing compound metabolic process|9.05|PGLS,IDH1,TKT,HINT1,ATIC,SLC4A7,IMPDH2|
|nucleobase-containing small molecule metabolic process|8.24|PGLS,IDH1,TKT,HINT1,AK6,ATIC,SLC4A7,IMPDH2|
|organophosphate metabolic process|7.03|PFKP,HK2,PGLS,IDH1,TKT,MOCS3,HINT1,AK6,ATIC,SLC4A7,IMPDH2|
|carbohydrate derivative metabolic process|5.43|PFKP,HK2,STT3B,PGLS,TKT,HINT1,ATIC,IMPDH2,MAGT1|
</modal>