====== UM0131023 0.05μM R05 exp248 ======
==== Mechanism of Action ====
Unknown
  * **<color #00a2e8>Class / Subclass 1:</color>** Uncharacterized Mechanism / Chemical Screen Hit




==== Technical Notes ====
<accordion collapsed='true'>
<panel title='Protein References' collapsed='true'>
    * **<color #00a2e8>PubChem Name:</color>** %%N/A%%
    * **<color #00a2e8>Synonyms:</color>** N/A
    * **<color #00a2e8>CAS #:</color>** N/A
    * **<color #00a2e8>PubChem CID:</color>** N/A
    * **<color #00a2e8>IUPAC:</color>** %%N/A%%
    * **<color #00a2e8>INCHI Name:</color>** N/A
    * **<color #00a2e8>INCHI Key:</color>** N/A
    * **<color #00a2e8>Molecular Weight:</color>** 582.61
    * **<color #00a2e8>Canonical SMILES:</color>** N/A
    * **<color #00a2e8>Isomeric SMILES:</color>** N/A
    * **<color #00a2e8>Molecular Formula:</color>** C33H29N2O.C2O2F3
{{:chemogenomics:structures:chem-0152.svg?nolink}}
</panel>


<panel title='Protein Supplier' collapsed='true'>
    * **<color #00a2e8>Supplier Name:</color>** In house - University of Montreal - Chemistry Platform
    * **<color #00a2e8>Catalog #:</color>** N/A
    * **<color #00a2e8>Lot #:</color>** IRIC-009 / JFL-2177-097 / Batch #01
</panel>


<panel title='Protein Characterization' collapsed='true'>
    * **<color #00a2e8>HRMS (ESI-TOF) m/z:</color>** (M+NH4)+ Calcd for C33H29N2O 487.26181; found 487.26162
</panel>


<panel title='Dose Response Curve' collapsed='true'>
    * **<color #00a2e8>Platform ID:</color>** UM0131023
    * **<color #00a2e8>Min:</color>** 28.5214; **<color #00a2e8>Max:</color>** 99.4598
{{:chemogenomics:dose_response:dr_138.png?nolink&500 |}}
\\ 
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|< 300px 100px 200px >|
^ IC   ^ Concentration (µM) ^
| IC10  |N/A    |
| IC20  |N/A    |
| IC30  |0.0253    |
| IC40  |0.0424    |
| IC50  |0.0681    |
| IC60  |N/A    |
| IC70  |N/A    |
| IC80  |N/A    |
| IC90  |N/A    |
\\ 
</panel>
</accordion>
==== Screen Summary ====
    * **<color #00a2e8>Round</color>**: 05
    * **<color #00a2e8>Dose</color>**: 50nM
    * **<color #00a2e8>Days of incubation</color>**: 8
    * **<color #00a2e8>Doublings</color>**: 5.8
    * **<color #00a2e8>Numbers of reads</color>**: 19294630


==== Screen Results ====


^Sensitive/Resistant hits (FDR<0.05)^CRANKS^Score Plot^Top 30 Genes^Screen Similarity^Top 30 Sensitive GO terms^Top 30 Resistant GO terms^
|9/17|<color #e85500>[[https://files.tyerslab.com/files/public/chemogenomics/cranks/UM0131023_0.05uM_Round-5_exp248.txt|Scores]]</color>|<button type="primary" size="sm" modal="ScorePlot">View</button>|<button type="primary" size="sm" modal="modal_hits">View</button>|<button type="primary" size="sm" modal="modal_screen_similarity">View</button>|<button type="primary" size="sm" modal="modal_go_sensitive">View</button>|<button type="primary" size="sm" modal="modal_go_resistant">View</button>|
<modal id='ScorePlot' size='lg' title='UM0131023 0.05μM R05 exp248'>
{{:chemogenomics:cranks_plots:exp248.png?nolink}}
</modal>


<modal id="modal_hits" size="sm" title="Top 30 S/R Genes">
^Gene^CRANKS Score^FDR^
|[[:human_genes:A:ABCC1|ABCC1]]|-3.84|<0.01|
|[[:human_genes:G:GOT1|GOT1]]|-3.41|<0.01|
|[[:human_genes:G:GCLM|GCLM]]|-3.25|<0.01|
|[[:human_genes:S:SZT2|SZT2]]|-3.23|<0.01|
|[[:human_genes:G:GCLC|GCLC]]|-2.72|0.04|
|[[:human_genes:O:OSGIN2|OSGIN2]]|-2.69|0.04|
|[[:human_genes:C:C6orf136|C6orf136]]|-2.67|0.04|
|[[:human_genes:S:SLC25A20|SLC25A20]]|-2.61|0.04|
|[[:human_genes:S:SLC22A14|SLC22A14]]|-2.55|0.04|
|[[:human_genes:P:PTEN|PTEN]]|-2.43|0.06|
|[[:human_genes:U:UBE2N|UBE2N]]|-2.41|0.11|
|[[:human_genes:N:NUDT5|NUDT5]]|-2.41|0.11|
|[[:human_genes:S:SEPHS2|SEPHS2]]|-2.41|0.06|
|[[:human_genes:R:RNPS1|RNPS1]]|-2.35|0.21|
|[[:human_genes:S:SRP14|SRP14]]|-2.31|0.10|
|[[:human_genes:S:SUCLA2|SUCLA2]]|-2.29|0.18|
|[[:human_genes:Q:QRICH1|QRICH1]]|-2.25|0.26|
|[[:human_genes:S:SUCLG1|SUCLG1]]|-2.25|0.19|
|[[:human_genes:U:UHRF1|UHRF1]]|-2.22|0.21|
|[[:human_genes:M:METTL16|METTL16]]|-2.21|0.55|
|[[:human_genes:S:SWI5|SWI5]]|-2.15|0.25|
|[[:human_genes:P:PRDX1|PRDX1]]|-2.15|0.18|
|[[:human_genes:R:RHOA|RHOA]]|-2.12|0.19|
|[[:human_genes:S:SAFB|SAFB]]|-2.11|0.26|
|[[:human_genes:X:XRN1|XRN1]]|-2.11|0.31|
|[[:human_genes:F:FNTA|FNTA]]|-2.08|0.21|
|[[:human_genes:A:ATP8B2|ATP8B2]]|-2.06|0.41|
|[[:human_genes:A:ABHD3|ABHD3]]|-2.05|0.28|
|[[:human_genes:P:PTPN6|PTPN6]]|-2.05|0.24|
|[[:human_genes:V:VPS36|VPS36]]|-2.03|0.25|
|[[:human_genes:M:MMD|MMD]]|2.31|0.05|
|[[:human_genes:M:MTHFD2|MTHFD2]]|2.34|0.05|
|[[:human_genes:R:RPL14|RPL14]]|2.38|0.18|
|[[:human_genes:S:SF3A1|SF3A1]]|2.40|0.23|
|[[:human_genes:S:SHOC2|SHOC2]]|2.43|0.06|
|[[:human_genes:F:FAF2|FAF2]]|2.45|0.05|
|[[:human_genes:T:TBRG4|TBRG4]]|2.45|0.05|
|[[:human_genes:C:COPB2|COPB2]]|2.47|0.22|
|[[:human_genes:C:C19orf43|C19orf43]]|2.49|0.05|
|[[:human_genes:S:SLC7A1|SLC7A1]]|2.50|0.15|
|[[:human_genes:S:SHMT2|SHMT2]]|2.51|0.08|
|[[:human_genes:T:TADA2A|TADA2A]]|2.51|0.02|
|[[:human_genes:H:HMHA1|HMHA1]]|2.55|0.04|
|[[:human_genes:E:ERGIC1|ERGIC1]]|2.56|0.04|
|[[:human_genes:P:PRPS1|PRPS1]]|2.58|0.02|
|[[:human_genes:D:DNAJC24|DNAJC24]]|2.65|0.01|
|[[:human_genes:P:PSME3|PSME3]]|2.73|<0.01|
|[[:human_genes:P:POLE2|POLE2]]|2.78|0.21|
|[[:human_genes:S:SLC1A5|SLC1A5]]|2.84|0.05|
|[[:human_genes:C:CD19|CD19]]|2.85|0.01|
|[[:human_genes:A:AK6|AK6]]|2.93|<0.01|
|[[:human_genes:P:PDHA1|PDHA1]]|3.02|<0.01|
|[[:human_genes:M:MDH1|MDH1]]|3.04|<0.01|
|[[:human_genes:C:CNOT2|CNOT2]]|3.05|<0.01|
|[[:human_genes:A:ACSL4|ACSL4]]|3.11|<0.01|
|[[:human_genes:P:PPRC1|PPRC1]]|3.14|<0.01|
|[[:human_genes:S:SLC25A32|SLC25A32]]|3.14|<0.01|
|[[:human_genes:K:KCNJ2|KCNJ2]]|3.29|<0.01|
|[[:human_genes:A:ARID4B|ARID4B]]|3.42|<0.01|
|[[:human_genes:M:MTA2|MTA2]]|3.45|<0.01|
</modal>


<modal id="modal_screen_similarity" size="lg" title="Correlated Screens">
^Screen^Correlation^Plot^
|[[:results:exp274|Citral 50μM R06 exp274]]|0.112|<button type="primary" size="small" modal="1">View</button>|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|0.084|<button type="primary" size="small" modal="2">View</button>|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|0.072|<button type="primary" size="small" modal="3">View</button>|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|0.066|<button type="primary" size="small" modal="4">View</button>|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|0.062|<button type="primary" size="small" modal="5">View</button>|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|0.06|<button type="primary" size="small" modal="6">View</button>|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|0.057|<button type="primary" size="small" modal="7">View</button>|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|0.057|<button type="primary" size="small" modal="8">View</button>|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|0.055|<button type="primary" size="small" modal="9">View</button>|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|0.052|<button type="primary" size="small" modal="10">View</button>|
|[[:results:exp292|Menadione 5μM R06 exp292]]|0.051|<button type="primary" size="small" modal="11">View</button>|
</modal>


<modal id="1" size="lg" title="Citral 50μM R06 exp274  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp248_vs_exp274.png?nolink |}}
</modal>

<modal id="2" size="lg" title="Deguelin 0.15μM R05 exp209  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp209_vs_exp248.png?nolink |}}
</modal>

<modal id="3" size="lg" title="Phenformin 20μM R05 exp212  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp212_vs_exp248.png?nolink |}}
</modal>

<modal id="4" size="lg" title="Doxycycline 10μM R00 exp18  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp18_vs_exp248.png?nolink |}}
</modal>

<modal id="5" size="lg" title="QNZ 0.01μM R05 exp241  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp241_vs_exp248.png?nolink |}}
</modal>

<modal id="6" size="lg" title="GSK-J4 1-1.25μM to day4 R07 exp363  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp248_vs_exp363.png?nolink |}}
</modal>

<modal id="7" size="lg" title="Hypoxia 5%O2 R04 exp191  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp191_vs_exp248.png?nolink |}}
</modal>

<modal id="8" size="lg" title="Nifuroxazide 5μM R03 exp102  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp102_vs_exp248.png?nolink |}}
</modal>

<modal id="9" size="lg" title="GSK-J4 1μM R07 exp362  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp248_vs_exp362.png?nolink |}}
</modal>

<modal id="10" size="lg" title="Amiloride 100μM R08 exp447  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp248_vs_exp447.png?nolink |}}
</modal>

<modal id="11" size="lg" title="Menadione 5μM R06 exp292  vs  UM0131023 0.05μM R05 exp248">
{{:chemogenomics:comparison_plots:exp248_vs_exp292.png?nolink |}}
</modal>



<modal id="modal_go_sensitive" size="lg" title="Top 30 sensitive GO terms">
^GO Term^Fold Change^Genes^
|succinate-CoA ligase activity|591.79|SUCLA2,SUCLG1|
|response to human chorionic gonadotropin|295.89|GCLM,GCLC|
|response to L-phenylalanine derivative|236.71|GCLM,GCLC|
|glutamate metabolic process|63.41|GOT1,GCLM,GCLC|
|dicarboxylic acid metabolic process|26.90|GOT1,GCLM,GCLC,SUCLA2|
|cellular nitrogen compound catabolic process|12.67|ABCC1,NUDT5,RNPS1,SUCLA2,SUCLG1,METTL16,XRN1|
|nucleobase-containing compound catabolic process|12.59|NUDT5,RNPS1,SUCLA2,SUCLG1,METTL16,XRN1|
|heterocycle catabolic process|12.59|ABCC1,NUDT5,RNPS1,SUCLA2,SUCLG1,METTL16,XRN1|
|aromatic compound catabolic process|12.22|ABCC1,NUDT5,RNPS1,SUCLA2,SUCLG1,METTL16,XRN1|
|organic cyclic compound catabolic process|11.11|ABCC1,NUDT5,RNPS1,SUCLA2,SUCLG1,METTL16,XRN1|
</modal>
<modal id="modal_go_resistant" size="lg" title="Top 30 resistant GO terms">
^GO Term^Fold Change^Genes^
|folic acid metabolic process|118.36|SLC25A32,SHMT2,MTHFD2|
</modal>